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Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats.
Brain Res. 1998 Oct 26; 809(1):1-4.BR

Abstract

The effects of acute and repeated administration of Delta9-tetrahydrocannabinol (Delta9-THC), the psychoactive principle of marijuana, on acetylcholine release in the hippocampus was studied in freely moving rats by microdialysis. The acute intraperitoneal (i.p.) administration of Delta9-THC at the doses of 2.5 and 5 mg/kg reduced acetylcholine release by about 25% and 45%, respectively. A dose of 7.5 mg/kg produced no further reduction. Delta9-THC effects were antagonized by the cannabinoid CB1 antagonist SR141716A at the i.p. dose of 1 mg/kg, per se ineffective in modifying acetylcholine concentrations. After a repeated exposure (twice daily for up to seven days) to Delta9-THC (7.5 mg/kg, i.p.) or vehicle (0.3 ml/kg, i.p.), the inhibitory effect of Delta9-THC (2.5 and 5 mg/kg, i.p) on acetylcholine release was not reduced. The results confirm previous observations that cannabinoids inhibit acetylcholine release through cannabinoid CB1 receptors, and indicate that no tolerance to this effects develops after a repeated Delta9-THC administration.

Authors+Show Affiliations

Guy M. Everett Laboratory of Neuropsychopharmacology, Department of Neuroscience 'Bernard B. Brodie', University of Cagliari, Via Porcell 4, 09124, Cagliari, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9795096

Citation

Carta, G, et al. "Inhibition of Hippocampal Acetylcholine Release After Acute and Repeated Delta9-tetrahydrocannabinol in Rats." Brain Research, vol. 809, no. 1, 1998, pp. 1-4.
Carta G, Nava F, Gessa GL. Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats. Brain Res. 1998;809(1):1-4.
Carta, G., Nava, F., & Gessa, G. L. (1998). Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats. Brain Research, 809(1), 1-4.
Carta G, Nava F, Gessa GL. Inhibition of Hippocampal Acetylcholine Release After Acute and Repeated Delta9-tetrahydrocannabinol in Rats. Brain Res. 1998 Oct 26;809(1):1-4. PubMed PMID: 9795096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats. AU - Carta,G, AU - Nava,F, AU - Gessa,G L, PY - 1998/10/31/pubmed PY - 1998/10/31/medline PY - 1998/10/31/entrez SP - 1 EP - 4 JF - Brain research JO - Brain Res VL - 809 IS - 1 N2 - The effects of acute and repeated administration of Delta9-tetrahydrocannabinol (Delta9-THC), the psychoactive principle of marijuana, on acetylcholine release in the hippocampus was studied in freely moving rats by microdialysis. The acute intraperitoneal (i.p.) administration of Delta9-THC at the doses of 2.5 and 5 mg/kg reduced acetylcholine release by about 25% and 45%, respectively. A dose of 7.5 mg/kg produced no further reduction. Delta9-THC effects were antagonized by the cannabinoid CB1 antagonist SR141716A at the i.p. dose of 1 mg/kg, per se ineffective in modifying acetylcholine concentrations. After a repeated exposure (twice daily for up to seven days) to Delta9-THC (7.5 mg/kg, i.p.) or vehicle (0.3 ml/kg, i.p.), the inhibitory effect of Delta9-THC (2.5 and 5 mg/kg, i.p) on acetylcholine release was not reduced. The results confirm previous observations that cannabinoids inhibit acetylcholine release through cannabinoid CB1 receptors, and indicate that no tolerance to this effects develops after a repeated Delta9-THC administration. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/9795096/Inhibition_of_hippocampal_acetylcholine_release_after_acute_and_repeated_Delta9_tetrahydrocannabinol_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(98)00738-0 DB - PRIME DP - Unbound Medicine ER -