TY - JOUR T1 - Effect of omeprazole on gastric bicarbonate secretion in patients with duodenal ulcer. AU - Singh,K, AU - Nain,C K, AU - Singh,V, PY - 1998/10/31/pubmed PY - 1998/10/31/medline PY - 1998/10/31/entrez SP - 136 EP - 7 JF - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology JO - Indian J Gastroenterol VL - 17 IS - 4 N2 - BACKGROUND: Omeprazole, a H+/K+ ATPase inhibitor, has been shown to reduce gastric bicarbonate secretion in cats. However, there has been no study on the effect of omeprazole on bicarbonate secretion in patients with duodenal ulcer (DU). METHODS: Fifteen men with duodenal ulcer (mean age 38 years, range 22-57) were included. Baseline gastric acid output, bicarbonate secretion, and parietal and nonparietal secretions were estimated before and after omeprazole therapy (20 mg/day) for four weeks. RESULTS: Omeprazole administration did not significantly alter bicarbonate secretion (3.3 [1.2] vs 2.4 [0.4] mmol/h), though there was significant reduction in gastric acidity (44.2 [6.6] vs 20.7 [4.6] mmol/L, p < 0.01). CONCLUSION: Omeprazole reduces acid secretion but does not affect gastric bicarbonate secretion in patients with DU. SN - 0254-8860 UR - https://www.unboundmedicine.com/medline/citation/9795500/Effect_of_omeprazole_on_gastric_bicarbonate_secretion_in_patients_with_duodenal_ulcer_ DB - PRIME DP - Unbound Medicine ER -