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Effects of levodopa on nocturnal penile tumescence: a preliminary study.
J Androl. 1998 Sep-Oct; 19(5):619-24.JA

Abstract

We studied the effects of levodopa (L-dopa), which is reported to increase the dopamine level in the brain, on male erectile function. Of the 21 subjects studied, 12 subjects who were 50 years old or older showed significant increases of two nocturnal penile tumescence (NPT) parameters, NPT frequency and total tumescence time, with L-dopa. On the other hand, in nine subjects who were younger than 50 years, maximum penile circumference increase showed a significant increment with L-dopa. This significant increment of NPT with L-dopa was not observed in the subjects who had low androgen levels. The results of this preliminary study show a positive relationship between administration of L-dopa and erectile function. L-Dopa administration may improve erectile function in subjects aged 50 years and older who have normal androgen levels.

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Authors+Show Affiliations

Horita H
Department of Urology, Sapporo Medical University School of Medicine, Japan.
Sato Y
No affiliation info available
Adachi H
No affiliation info available
Suzuki N
No affiliation info available
Kato R
No affiliation info available
Hisasue S
No affiliation info available
Suzuki K
No affiliation info available
Tsukamoto T
No affiliation info available

MeSH

AdultAgedAgingHumansLevodopaMaleMiddle AgedPenile ErectionPenisSleepSleep, REMTestosterone

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

9796623

Citation

Horita, H, et al. "Effects of Levodopa On Nocturnal Penile Tumescence: a Preliminary Study." Journal of Andrology, vol. 19, no. 5, 1998, pp. 619-24.
Horita H, Sato Y, Adachi H, et al. Effects of levodopa on nocturnal penile tumescence: a preliminary study. J Androl. 1998;19(5):619-24.
Horita, H., Sato, Y., Adachi, H., Suzuki, N., Kato, R., Hisasue, S., Suzuki, K., & Tsukamoto, T. (1998). Effects of levodopa on nocturnal penile tumescence: a preliminary study. Journal of Andrology, 19(5), 619-24.
Horita H, et al. Effects of Levodopa On Nocturnal Penile Tumescence: a Preliminary Study. J Androl. 1998 Sep-Oct;19(5):619-24. PubMed PMID: 9796623.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of levodopa on nocturnal penile tumescence: a preliminary study. AU - Horita,H, AU - Sato,Y, AU - Adachi,H, AU - Suzuki,N, AU - Kato,R, AU - Hisasue,S, AU - Suzuki,K, AU - Tsukamoto,T, PY - 1998/10/31/pubmed PY - 1998/10/31/medline PY - 1998/10/31/entrez SP - 619 EP - 24 JF - Journal of andrology JO - J Androl VL - 19 IS - 5 N2 - We studied the effects of levodopa (L-dopa), which is reported to increase the dopamine level in the brain, on male erectile function. Of the 21 subjects studied, 12 subjects who were 50 years old or older showed significant increases of two nocturnal penile tumescence (NPT) parameters, NPT frequency and total tumescence time, with L-dopa. On the other hand, in nine subjects who were younger than 50 years, maximum penile circumference increase showed a significant increment with L-dopa. This significant increment of NPT with L-dopa was not observed in the subjects who had low androgen levels. The results of this preliminary study show a positive relationship between administration of L-dopa and erectile function. L-Dopa administration may improve erectile function in subjects aged 50 years and older who have normal androgen levels. SN - 0196-3635 UR - https://www.unboundmedicine.com/medline/citation/9796623/Effects_of_levodopa_on_nocturnal_penile_tumescence:_a_preliminary_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0196-3635&date=1998&volume=19&issue=5&spage=619 DB - PRIME DP - Unbound Medicine ER -