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A comparison of the neuromuscular blocking effects and reversibility of cisatracurium and atracurium.
Anaesthesia. 1998 Aug; 53(8):744-8.A

Abstract

The neuromuscular blocking effects and the reversibility of cisatracurium 0.1 or 0.15 mg.kg-1 were compared with those of atracurium 0.5 mg.kg-1 during anaesthesia with propofol, nitrous oxide and isoflurane. Neuromuscular block was monitored using train-of-four stimulation while recording the mechanomyographic response of the adductor pollicis muscle. The block was either allowed to recover spontaneously or was antagonised with neostigmine 50 micrograms.kg-1 at 10% or 25% recovery of the first twitch of the train-of-four. The median times to maximum block were 2.7, 2.2 and 1.5 min following cisatracurium 0.1 and 0.15 mg.kg-1 and atracurium 0.5 mg.kg-1, respectively. After cisatracurium 0.1 mg.kg-1 had been given, the median time to recovery of the train-of-four ratio to 0.8 ('adequate recovery') was 74 min during spontaneous recovery, 48 min after reversal with neostigmine when the first twitch of the train-of-four had returned to 10% of control and 50 min after reversal when the first twitch of the train-of-four had returned to 25% of control. These times for cisatracurium 0.15 mg.kg-1 and atracurium 0.5 mg.kg-1 were 90, 66 and 57 min and 75, 56 and 54 min, respectively. Administration of neostigmine significantly shortened the time to adequate recovery for both drugs but there were no significant differences in the case of either neuromuscular blocking drug between the groups of patients given neostigmine at 10 or 25% recovery of the first twitch of the train-of-four.

Authors+Show Affiliations

Department of Anaesthetics, Queen's University of Belfast, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9797517

Citation

Carroll, M T., et al. "A Comparison of the Neuromuscular Blocking Effects and Reversibility of Cisatracurium and Atracurium." Anaesthesia, vol. 53, no. 8, 1998, pp. 744-8.
Carroll MT, Mirakhur RK, Lowry D, et al. A comparison of the neuromuscular blocking effects and reversibility of cisatracurium and atracurium. Anaesthesia. 1998;53(8):744-8.
Carroll, M. T., Mirakhur, R. K., Lowry, D., Glover, P., & Kerr, C. J. (1998). A comparison of the neuromuscular blocking effects and reversibility of cisatracurium and atracurium. Anaesthesia, 53(8), 744-8.
Carroll MT, et al. A Comparison of the Neuromuscular Blocking Effects and Reversibility of Cisatracurium and Atracurium. Anaesthesia. 1998;53(8):744-8. PubMed PMID: 9797517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the neuromuscular blocking effects and reversibility of cisatracurium and atracurium. AU - Carroll,M T, AU - Mirakhur,R K, AU - Lowry,D, AU - Glover,P, AU - Kerr,C J, PY - 1998/11/3/pubmed PY - 1998/11/3/medline PY - 1998/11/3/entrez SP - 744 EP - 8 JF - Anaesthesia JO - Anaesthesia VL - 53 IS - 8 N2 - The neuromuscular blocking effects and the reversibility of cisatracurium 0.1 or 0.15 mg.kg-1 were compared with those of atracurium 0.5 mg.kg-1 during anaesthesia with propofol, nitrous oxide and isoflurane. Neuromuscular block was monitored using train-of-four stimulation while recording the mechanomyographic response of the adductor pollicis muscle. The block was either allowed to recover spontaneously or was antagonised with neostigmine 50 micrograms.kg-1 at 10% or 25% recovery of the first twitch of the train-of-four. The median times to maximum block were 2.7, 2.2 and 1.5 min following cisatracurium 0.1 and 0.15 mg.kg-1 and atracurium 0.5 mg.kg-1, respectively. After cisatracurium 0.1 mg.kg-1 had been given, the median time to recovery of the train-of-four ratio to 0.8 ('adequate recovery') was 74 min during spontaneous recovery, 48 min after reversal with neostigmine when the first twitch of the train-of-four had returned to 10% of control and 50 min after reversal when the first twitch of the train-of-four had returned to 25% of control. These times for cisatracurium 0.15 mg.kg-1 and atracurium 0.5 mg.kg-1 were 90, 66 and 57 min and 75, 56 and 54 min, respectively. Administration of neostigmine significantly shortened the time to adequate recovery for both drugs but there were no significant differences in the case of either neuromuscular blocking drug between the groups of patients given neostigmine at 10 or 25% recovery of the first twitch of the train-of-four. SN - 0003-2409 UR - https://www.unboundmedicine.com/medline/citation/9797517/A_comparison_of_the_neuromuscular_blocking_effects_and_reversibility_of_cisatracurium_and_atracurium_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0003-2409&date=1998&volume=53&issue=8&spage=744 DB - PRIME DP - Unbound Medicine ER -