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Genetic modulation of coagulation factor VII plasma levels: contribution of different polymorphisms and gender-related effects.
Thromb Haemost. 1998 Oct; 80(4):592-7.TH

Abstract

We studied the relationships among different polymorphisms of FVII gene in determining FVII levels, in a sample of 335 male and female Italian volunteers. The hypervariable region 4 (HVR4), the promoter decanucleotide insertion (-323 0/10 bp) and the R353Q polymorphisms of FVII gene were evaluated. The association of HVR4 or -323 0/10 bp polymorphism with plasma FVII levels differed between gender (Interaction term: p = 0.02 and p = 0.03, respectively), showing stronger effect in males than in females. In males, the R353Q and the HVR4 polymorphisms showed an incremental influence on FVII variance (F = 8.9, p <0.001 and F = 4.4, p = 0.01, respectively). Moreover, the effects of Q and 10 bp alleles on the reduction of FVII activity levels were significantly potentiated by the presence of H7 allele of HVR4 (Interaction term p = 0.03 for R353Q*HVR4 and p = 0.03 for -323 0/10 bp*HVR4). In conclusion, the effect of FVII polymorphisms on FVII levels was gender dependent and derived from a complex interaction among them. The HVR4 polymorphism seems to add an independent, albeit small, contribution to the regulation of FVII plasma levels.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Department of Vascular Medicine and Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9798976

Citation

Di Castelnuovo, A, et al. "Genetic Modulation of Coagulation Factor VII Plasma Levels: Contribution of Different Polymorphisms and Gender-related Effects." Thrombosis and Haemostasis, vol. 80, no. 4, 1998, pp. 592-7.
Di Castelnuovo A, D'Orazio A, Amore C, et al. Genetic modulation of coagulation factor VII plasma levels: contribution of different polymorphisms and gender-related effects. Thromb Haemost. 1998;80(4):592-7.
Di Castelnuovo, A., D'Orazio, A., Amore, C., Falanga, A., Kluft, C., Donati, M. B., & Iacoviello, L. (1998). Genetic modulation of coagulation factor VII plasma levels: contribution of different polymorphisms and gender-related effects. Thrombosis and Haemostasis, 80(4), 592-7.
Di Castelnuovo A, et al. Genetic Modulation of Coagulation Factor VII Plasma Levels: Contribution of Different Polymorphisms and Gender-related Effects. Thromb Haemost. 1998;80(4):592-7. PubMed PMID: 9798976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic modulation of coagulation factor VII plasma levels: contribution of different polymorphisms and gender-related effects. AU - Di Castelnuovo,A, AU - D'Orazio,A, AU - Amore,C, AU - Falanga,A, AU - Kluft,C, AU - Donati,M B, AU - Iacoviello,L, PY - 1998/11/3/pubmed PY - 1998/11/3/medline PY - 1998/11/3/entrez SP - 592 EP - 7 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 80 IS - 4 N2 - We studied the relationships among different polymorphisms of FVII gene in determining FVII levels, in a sample of 335 male and female Italian volunteers. The hypervariable region 4 (HVR4), the promoter decanucleotide insertion (-323 0/10 bp) and the R353Q polymorphisms of FVII gene were evaluated. The association of HVR4 or -323 0/10 bp polymorphism with plasma FVII levels differed between gender (Interaction term: p = 0.02 and p = 0.03, respectively), showing stronger effect in males than in females. In males, the R353Q and the HVR4 polymorphisms showed an incremental influence on FVII variance (F = 8.9, p <0.001 and F = 4.4, p = 0.01, respectively). Moreover, the effects of Q and 10 bp alleles on the reduction of FVII activity levels were significantly potentiated by the presence of H7 allele of HVR4 (Interaction term p = 0.03 for R353Q*HVR4 and p = 0.03 for -323 0/10 bp*HVR4). In conclusion, the effect of FVII polymorphisms on FVII levels was gender dependent and derived from a complex interaction among them. The HVR4 polymorphism seems to add an independent, albeit small, contribution to the regulation of FVII plasma levels. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/9798976/Genetic_modulation_of_coagulation_factor_VII_plasma_levels:_contribution_of_different_polymorphisms_and_gender_related_effects_ DB - PRIME DP - Unbound Medicine ER -