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Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters.
Horm Behav. 1998 Oct; 34(2):149-62.HB

Abstract

The effects of chronic estrogen treatment on radial arm maze performance and on levels of central monoaminergic and amino acid neurotransmitters were examined in ovariectomized (Ovx) rats. In an eight arms baited paradigm, choice accuracy was enhanced following 12 days but not 3 days of treatment. In addition, performance during acquisition of the eight arms baited maze task was better in estrogen-treated Ovx rats than in Ovx rats. Performance of treated rats was also enhanced in win-shift trials conducted 12 days postestrogen treatment. Working, reference, and working-reference memory was examined when four of the eight arms were baited, and only working memory was improved by estrogen and only after long-term treatment. Activity of Ovx rats on an open field, crossings and rearings, was increased at 5 but not at 35 days following estrogen treatment. In medial prefrontal cortex, levels of NE, DA, and 5-HT were decreased but glutamate and GABA levels were not affected following chronic estrogen treatment. Basal forebrain nuclei also showed changes in monoamines following estrogen. Hippocampal subfields showed no effects of estrogen treatment on monoaminergic or amino acid transmitters. Levels of GABA were increased in the vertical diagonal bands following chronic estrogen. Results show that estrogen enhances learning/memory on a task utilizing spatial memory. Effects in Ovx rats appear to require the chronic (several days) presence of estrogen. Changes in activity of both monoaminergic and amino acid transmitters in the frontal cortex and basal forebrain may contribute to enhancing effects of estrogen on learning/memory.

Authors+Show Affiliations

Luine VN
Department of Psychology, Hunter College, 695 Park Avenue, New York, New York, 10021, USA. vluine@shiva.huner.cuny.edu
Richards ST
No affiliation info available
Wu VY
No affiliation info available
Beck KD
No affiliation info available

MeSH

AnimalsBiogenic MonoaminesBrain ChemistryEstradiolFemaleLearningMaze LearningMemoryMemory, Short-TermNeurotransmitter AgentsOvariectomyPsychomotor PerformanceRatsRats, Sprague-DawleySpace PerceptionStimulation, Chemical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9799625

Citation

Luine, V N., et al. "Estradiol Enhances Learning and Memory in a Spatial Memory Task and Effects Levels of Monoaminergic Neurotransmitters." Hormones and Behavior, vol. 34, no. 2, 1998, pp. 149-62.
Luine VN, Richards ST, Wu VY, et al. Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters. Horm Behav. 1998;34(2):149-62.
Luine, V. N., Richards, S. T., Wu, V. Y., & Beck, K. D. (1998). Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters. Hormones and Behavior, 34(2), 149-62.
Luine VN, et al. Estradiol Enhances Learning and Memory in a Spatial Memory Task and Effects Levels of Monoaminergic Neurotransmitters. Horm Behav. 1998;34(2):149-62. PubMed PMID: 9799625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters. AU - Luine,V N, AU - Richards,S T, AU - Wu,V Y, AU - Beck,K D, PY - 1998/11/4/pubmed PY - 1998/11/4/medline PY - 1998/11/4/entrez SP - 149 EP - 62 JF - Hormones and behavior JO - Horm Behav VL - 34 IS - 2 N2 - The effects of chronic estrogen treatment on radial arm maze performance and on levels of central monoaminergic and amino acid neurotransmitters were examined in ovariectomized (Ovx) rats. In an eight arms baited paradigm, choice accuracy was enhanced following 12 days but not 3 days of treatment. In addition, performance during acquisition of the eight arms baited maze task was better in estrogen-treated Ovx rats than in Ovx rats. Performance of treated rats was also enhanced in win-shift trials conducted 12 days postestrogen treatment. Working, reference, and working-reference memory was examined when four of the eight arms were baited, and only working memory was improved by estrogen and only after long-term treatment. Activity of Ovx rats on an open field, crossings and rearings, was increased at 5 but not at 35 days following estrogen treatment. In medial prefrontal cortex, levels of NE, DA, and 5-HT were decreased but glutamate and GABA levels were not affected following chronic estrogen treatment. Basal forebrain nuclei also showed changes in monoamines following estrogen. Hippocampal subfields showed no effects of estrogen treatment on monoaminergic or amino acid transmitters. Levels of GABA were increased in the vertical diagonal bands following chronic estrogen. Results show that estrogen enhances learning/memory on a task utilizing spatial memory. Effects in Ovx rats appear to require the chronic (several days) presence of estrogen. Changes in activity of both monoaminergic and amino acid transmitters in the frontal cortex and basal forebrain may contribute to enhancing effects of estrogen on learning/memory. SN - 0018-506X UR - https://www.unboundmedicine.com/medline/citation/9799625/Estradiol_enhances_learning_and_memory_in_a_spatial_memory_task_and_effects_levels_of_monoaminergic_neurotransmitters_ DB - PRIME DP - Unbound Medicine ER -