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Behavioral impairment under alcohol: cognitive and pharmacokinetic factors.
Alcohol Clin Exp Res. 1998 Oct; 22(7):1476-82.AC

Abstract

This study tested the hypothesis that the intensity of behavioral impairment under alcohol is related to social drinkers' expectancies about impairment and their rates of rise in blood alcohol concentration (BAC). After subjects (n = 30) were trained on a psychomotor task, they rated the impairment they expected from alcohol and then performed the task under alcohol (0.56 g/kg) or a placebo. Alcohol impaired performance, compared with placebo. Drinkers' expectations about impairment and their rates of rise in BAC were independent, and each factor predicted a significant portion of the variance in alcohol impairment among drinkers. More intense impairment under alcohol was associated with expectations of greater impairment and with swifter rates of rise in BAC. BACs obtained by drinkers during task performance were not related to the intensity of impairment they displayed. The study shows that a pharmacological and nonpharmacological variable can each affect a drinker's behavioral impairment under alcohol, and this finding contributes to our understanding of conditions where BAC per se may be an unreliable indicator of impairment.

Authors+Show Affiliations

Department of Psychology, University of Waterloo, Ontario, Canada.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9802531

Citation

Fillmore, M T., and M Vogel-Sprott. "Behavioral Impairment Under Alcohol: Cognitive and Pharmacokinetic Factors." Alcoholism, Clinical and Experimental Research, vol. 22, no. 7, 1998, pp. 1476-82.
Fillmore MT, Vogel-Sprott M. Behavioral impairment under alcohol: cognitive and pharmacokinetic factors. Alcohol Clin Exp Res. 1998;22(7):1476-82.
Fillmore, M. T., & Vogel-Sprott, M. (1998). Behavioral impairment under alcohol: cognitive and pharmacokinetic factors. Alcoholism, Clinical and Experimental Research, 22(7), 1476-82.
Fillmore MT, Vogel-Sprott M. Behavioral Impairment Under Alcohol: Cognitive and Pharmacokinetic Factors. Alcohol Clin Exp Res. 1998;22(7):1476-82. PubMed PMID: 9802531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral impairment under alcohol: cognitive and pharmacokinetic factors. AU - Fillmore,M T, AU - Vogel-Sprott,M, PY - 1998/11/5/pubmed PY - 1998/11/5/medline PY - 1998/11/5/entrez SP - 1476 EP - 82 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 22 IS - 7 N2 - This study tested the hypothesis that the intensity of behavioral impairment under alcohol is related to social drinkers' expectancies about impairment and their rates of rise in blood alcohol concentration (BAC). After subjects (n = 30) were trained on a psychomotor task, they rated the impairment they expected from alcohol and then performed the task under alcohol (0.56 g/kg) or a placebo. Alcohol impaired performance, compared with placebo. Drinkers' expectations about impairment and their rates of rise in BAC were independent, and each factor predicted a significant portion of the variance in alcohol impairment among drinkers. More intense impairment under alcohol was associated with expectations of greater impairment and with swifter rates of rise in BAC. BACs obtained by drinkers during task performance were not related to the intensity of impairment they displayed. The study shows that a pharmacological and nonpharmacological variable can each affect a drinker's behavioral impairment under alcohol, and this finding contributes to our understanding of conditions where BAC per se may be an unreliable indicator of impairment. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/9802531/Behavioral_impairment_under_alcohol:_cognitive_and_pharmacokinetic_factors_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=1998&volume=22&issue=7&spage=1476 DB - PRIME DP - Unbound Medicine ER -