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Fibromyalgia and the serotonin pathway.
Altern Med Rev. 1998 Oct; 3(5):367-75.AM

Abstract

Fibromyalgia syndrome is a musculoskeletal pain and fatigue disorder manifested by diffuse myalgia, localized areas of tenderness, fatigue, lowered pain thresholds, and nonrestorative sleep. Evidence from multiple sources support the concept of decreased flux through the serotonin pathway in fibromyalgia patients. Serotonin substrate supplementation, via L-tryptophan or 5-hydroxytryptophan (5-HTP), has been shown to improve symptoms of depression, anxiety, insomnia and somatic pains in a variety of patient cohorts. Identification of low serum tryptophan and serotonin levels may be a simple way to identify persons who will respond well to this approach.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9802912

Citation

Juhl, J H.. "Fibromyalgia and the Serotonin Pathway." Alternative Medicine Review : a Journal of Clinical Therapeutic, vol. 3, no. 5, 1998, pp. 367-75.
Juhl JH. Fibromyalgia and the serotonin pathway. Altern Med Rev. 1998;3(5):367-75.
Juhl, J. H. (1998). Fibromyalgia and the serotonin pathway. Alternative Medicine Review : a Journal of Clinical Therapeutic, 3(5), 367-75.
Juhl JH. Fibromyalgia and the Serotonin Pathway. Altern Med Rev. 1998;3(5):367-75. PubMed PMID: 9802912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibromyalgia and the serotonin pathway. A1 - Juhl,J H, PY - 1998/11/5/pubmed PY - 1998/11/5/medline PY - 1998/11/5/entrez SP - 367 EP - 75 JF - Alternative medicine review : a journal of clinical therapeutic JO - Altern Med Rev VL - 3 IS - 5 N2 - Fibromyalgia syndrome is a musculoskeletal pain and fatigue disorder manifested by diffuse myalgia, localized areas of tenderness, fatigue, lowered pain thresholds, and nonrestorative sleep. Evidence from multiple sources support the concept of decreased flux through the serotonin pathway in fibromyalgia patients. Serotonin substrate supplementation, via L-tryptophan or 5-hydroxytryptophan (5-HTP), has been shown to improve symptoms of depression, anxiety, insomnia and somatic pains in a variety of patient cohorts. Identification of low serum tryptophan and serotonin levels may be a simple way to identify persons who will respond well to this approach. SN - 1089-5159 UR - https://www.unboundmedicine.com/medline/citation/9802912/Fibromyalgia_and_the_serotonin_pathway_ L2 - http://archive.foundationalmedicinereview.com/publications/3/5/367.pdf DB - PRIME DP - Unbound Medicine ER -
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