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Comparison of AIK-C measles vaccine in infants at 6 months with Schwarz vaccine at 9 months: a randomized controlled trial in Ghana.
Bull World Health Organ. 1998; 76(4):353-9.BW

Abstract

In a randomized controlled trial in a measles endemic area, standard-dose (4.0 log10pfu) AIK-C measles vaccine administered at 6 months of age was compared to standard-dose Schwarz vaccine (3.7log10pfu) given at 9 months. Seroconversion rates at 3 and 6 months after immunization in the two groups were comparable and similar. The geometric mean titres achieved were, however, significantly higher in the Schwarz group (P < 0.05). No immediate serious side-effects were observed with either vaccine. We conclude that standard-dose AIK-C measles vaccine can be recommended for measles immunization in children below 9 months of age, especially in highly endemic and high-risk areas in developing countries.

Authors+Show Affiliations

Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, Ghana.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9803586

Citation

Nkrumah, F K., et al. "Comparison of AIK-C Measles Vaccine in Infants at 6 Months With Schwarz Vaccine at 9 Months: a Randomized Controlled Trial in Ghana." Bulletin of the World Health Organization, vol. 76, no. 4, 1998, pp. 353-9.
Nkrumah FK, Osei-Kwasi M, Dunyo SK, et al. Comparison of AIK-C measles vaccine in infants at 6 months with Schwarz vaccine at 9 months: a randomized controlled trial in Ghana. Bull World Health Organ. 1998;76(4):353-9.
Nkrumah, F. K., Osei-Kwasi, M., Dunyo, S. K., Koram, K. A., & Afari, E. A. (1998). Comparison of AIK-C measles vaccine in infants at 6 months with Schwarz vaccine at 9 months: a randomized controlled trial in Ghana. Bulletin of the World Health Organization, 76(4), 353-9.
Nkrumah FK, et al. Comparison of AIK-C Measles Vaccine in Infants at 6 Months With Schwarz Vaccine at 9 Months: a Randomized Controlled Trial in Ghana. Bull World Health Organ. 1998;76(4):353-9. PubMed PMID: 9803586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of AIK-C measles vaccine in infants at 6 months with Schwarz vaccine at 9 months: a randomized controlled trial in Ghana. AU - Nkrumah,F K, AU - Osei-Kwasi,M, AU - Dunyo,S K, AU - Koram,K A, AU - Afari,E A, PY - 1998/11/6/pubmed PY - 1998/11/6/medline PY - 1998/11/6/entrez KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Child Health Services KW - Comparative Studies KW - Delivery Of Health Care KW - Demographic Factors KW - Developing Countries KW - Diseases KW - English Speaking Africa KW - Ghana KW - Health KW - Health Services KW - Immunization KW - Infant KW - Maternal-child Health Services KW - Measles--prevention and control KW - Population KW - Population Characteristics KW - Primary Health Care KW - Research Methodology KW - Research Report KW - Studies KW - Vaccination KW - Vaccines--administraction and dosage KW - Viral Diseases KW - Western Africa KW - Youth SP - 353 EP - 9 JF - Bulletin of the World Health Organization JO - Bull World Health Organ VL - 76 IS - 4 N2 - In a randomized controlled trial in a measles endemic area, standard-dose (4.0 log10pfu) AIK-C measles vaccine administered at 6 months of age was compared to standard-dose Schwarz vaccine (3.7log10pfu) given at 9 months. Seroconversion rates at 3 and 6 months after immunization in the two groups were comparable and similar. The geometric mean titres achieved were, however, significantly higher in the Schwarz group (P < 0.05). No immediate serious side-effects were observed with either vaccine. We conclude that standard-dose AIK-C measles vaccine can be recommended for measles immunization in children below 9 months of age, especially in highly endemic and high-risk areas in developing countries. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/9803586/Comparison_of_AIK_C_measles_vaccine_in_infants_at_6_months_with_Schwarz_vaccine_at_9_months:_a_randomized_controlled_trial_in_Ghana_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9803586/ DB - PRIME DP - Unbound Medicine ER -