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Genetic neurodegenerative diseases: the human illness and transgenic models.
Science. 1998 Nov 06; 282(5391):1079-83.Sci

Abstract

Review The neurodegenerative disorders, a heterogeneous group of chronic progressive diseases, are among the most puzzling and devastating illnesses in medicine. Some of these disorders, such as Alzheimer's disease, amyotrophic lateral sclerosis, the prion diseases, and Parkinson's disease, can occur sporadically and, in some instances, are caused by inheritance of gene mutations. Huntington's disease is acquired in an entirely genetic manner. Transgenic mice that express disease-causing genes recapitulate many features of these diseases. This review provides an overview of transgenic mouse models of familial amyotrophic lateral sclerosis, familial Alzheimer's disease, and Huntington's disease and the emerging insights relevant to the underlying molecular mechanisms of these diseases.

Authors+Show Affiliations

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. dlprice@welchlink.welch.jhu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

9804539

Citation

Price, D L., et al. "Genetic Neurodegenerative Diseases: the Human Illness and Transgenic Models." Science (New York, N.Y.), vol. 282, no. 5391, 1998, pp. 1079-83.
Price DL, Sisodia SS, Borchelt DR. Genetic neurodegenerative diseases: the human illness and transgenic models. Science. 1998;282(5391):1079-83.
Price, D. L., Sisodia, S. S., & Borchelt, D. R. (1998). Genetic neurodegenerative diseases: the human illness and transgenic models. Science (New York, N.Y.), 282(5391), 1079-83.
Price DL, Sisodia SS, Borchelt DR. Genetic Neurodegenerative Diseases: the Human Illness and Transgenic Models. Science. 1998 Nov 6;282(5391):1079-83. PubMed PMID: 9804539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic neurodegenerative diseases: the human illness and transgenic models. AU - Price,D L, AU - Sisodia,S S, AU - Borchelt,D R, PY - 1998/11/6/pubmed PY - 1998/11/6/medline PY - 1998/11/6/entrez SP - 1079 EP - 83 JF - Science (New York, N.Y.) JO - Science VL - 282 IS - 5391 N2 - Review The neurodegenerative disorders, a heterogeneous group of chronic progressive diseases, are among the most puzzling and devastating illnesses in medicine. Some of these disorders, such as Alzheimer's disease, amyotrophic lateral sclerosis, the prion diseases, and Parkinson's disease, can occur sporadically and, in some instances, are caused by inheritance of gene mutations. Huntington's disease is acquired in an entirely genetic manner. Transgenic mice that express disease-causing genes recapitulate many features of these diseases. This review provides an overview of transgenic mouse models of familial amyotrophic lateral sclerosis, familial Alzheimer's disease, and Huntington's disease and the emerging insights relevant to the underlying molecular mechanisms of these diseases. SN - 0036-8075 UR - https://www.unboundmedicine.com/medline/citation/9804539/Genetic_neurodegenerative_diseases:_the_human_illness_and_transgenic_models_ L2 - http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=9804539 DB - PRIME DP - Unbound Medicine ER -