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Effect of oral contraceptive progestins on serum copper concentration.
Eur J Clin Nutr. 1998 Oct; 52(10):711-5.EJ

Abstract

OBJECTIVES

Recent epidemiologic studies have shown an increased mortality from cardiovascular diseases in people with higher serum copper levels. Even though higher serum copper concentration in women using oral contraceptives is well known, there is still uncertainty about the influence of newer progestin compounds in oral contraceptives on serum copper concentration. This issue is of particular interest in the light of recent findings of an increased risk of venous thromboembolism in users of oral contraceptives containing newer progestins like desogestrel compared to users of other oral contraceptives.

DESIGN

Cross-sectional epidemiologic study. Examinations included a detailed questionnaire on medical history and lifestyle factors, a seven day food record, and blood samples.

SETTING

National health and nutrition survey among healthy people living in private homes in West Germany in 1987-1988.

SUBJECTS

Nonpregnant and nonlactating women aged 18-44 y (n = 610).

RESULTS

Overall, the use of oral contraceptives was positively associated with serum copper concentration in by bi- and multivariable linear regression models with log-transformed values of serum copper concentration as dependend variable and oral contraceptive preparations and potential confounding variables as independent variables. Serum copper concentration in women using oral contraceptives varied more strongly by different progestin compounds than by estrogen contents. The highest increase of serum copper was seen in women using oral contraceptives containing antiandrogen progestins (55%; 95% CI: 37-76%), followed by desogestrel (46%; 95% CI: 36-56%), norethisteron/lynestrenol (42%; 95% CI: 29-57%), and levonorgestrel (34%; 95% CI: 24-45%).

CONCLUSION

While elevated serum copper concentration was found in users of all types of oral contraceptives, elevation was more pronounced among women taking oral contraceptives with antiandrogen effective progestins like antiandrogens or third generation oral contraceptives containing desogestrel. Further investigation is required to shed light on the possible role of high serum copper concentration in increasing cardiovascular or thrombotic risk of women using oral contraceptives.

Authors+Show Affiliations

Department of Epidemiology, University of Ulm, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9805216

Citation

Berg, G, et al. "Effect of Oral Contraceptive Progestins On Serum Copper Concentration." European Journal of Clinical Nutrition, vol. 52, no. 10, 1998, pp. 711-5.
Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr. 1998;52(10):711-5.
Berg, G., Kohlmeier, L., & Brenner, H. (1998). Effect of oral contraceptive progestins on serum copper concentration. European Journal of Clinical Nutrition, 52(10), 711-5.
Berg G, Kohlmeier L, Brenner H. Effect of Oral Contraceptive Progestins On Serum Copper Concentration. Eur J Clin Nutr. 1998;52(10):711-5. PubMed PMID: 9805216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oral contraceptive progestins on serum copper concentration. AU - Berg,G, AU - Kohlmeier,L, AU - Brenner,H, PY - 1998/11/7/pubmed PY - 1998/11/7/medline PY - 1998/11/7/entrez KW - Biology KW - Cardiovascular Effects KW - Contraception KW - Contraceptive Agents, Estrogen--pharmacodynamics KW - Contraceptive Agents, Female--pharmacodynamics KW - Contraceptive Agents, Progestin--pharmacodynamics KW - Contraceptive Agents--pharmacodynamics KW - Contraceptive Methods--side effects KW - Cross Sectional Analysis KW - Desogestrel--pharmacodynamics KW - Developed Countries KW - Ethinyl Estradiol--pharmacodynamics KW - Europe KW - Family Planning KW - Germany, Federal Republic Of KW - Hemic System KW - Levonorgestrel--pharmacodynamics KW - Oral Contraceptives, Combined--side effects KW - Oral Contraceptives--side effects KW - Physiology KW - Research Methodology KW - Research Report KW - Serum Copper Level KW - Western Europe SP - 711 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 52 IS - 10 N2 - OBJECTIVES: Recent epidemiologic studies have shown an increased mortality from cardiovascular diseases in people with higher serum copper levels. Even though higher serum copper concentration in women using oral contraceptives is well known, there is still uncertainty about the influence of newer progestin compounds in oral contraceptives on serum copper concentration. This issue is of particular interest in the light of recent findings of an increased risk of venous thromboembolism in users of oral contraceptives containing newer progestins like desogestrel compared to users of other oral contraceptives. DESIGN: Cross-sectional epidemiologic study. Examinations included a detailed questionnaire on medical history and lifestyle factors, a seven day food record, and blood samples. SETTING: National health and nutrition survey among healthy people living in private homes in West Germany in 1987-1988. SUBJECTS: Nonpregnant and nonlactating women aged 18-44 y (n = 610). RESULTS: Overall, the use of oral contraceptives was positively associated with serum copper concentration in by bi- and multivariable linear regression models with log-transformed values of serum copper concentration as dependend variable and oral contraceptive preparations and potential confounding variables as independent variables. Serum copper concentration in women using oral contraceptives varied more strongly by different progestin compounds than by estrogen contents. The highest increase of serum copper was seen in women using oral contraceptives containing antiandrogen progestins (55%; 95% CI: 37-76%), followed by desogestrel (46%; 95% CI: 36-56%), norethisteron/lynestrenol (42%; 95% CI: 29-57%), and levonorgestrel (34%; 95% CI: 24-45%). CONCLUSION: While elevated serum copper concentration was found in users of all types of oral contraceptives, elevation was more pronounced among women taking oral contraceptives with antiandrogen effective progestins like antiandrogens or third generation oral contraceptives containing desogestrel. Further investigation is required to shed light on the possible role of high serum copper concentration in increasing cardiovascular or thrombotic risk of women using oral contraceptives. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/9805216/Effect_of_oral_contraceptive_progestins_on_serum_copper_concentration_ L2 - https://doi.org/10.1038/sj.ejcn.1600631 DB - PRIME DP - Unbound Medicine ER -