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[African tick-bite rickettsiosis: the 1st case of autochthonous infection?].
Ann Dermatol Venereol. 1998 Sep; 125(9):601-3.AD

Abstract

BACKGROUND

African tick-bite fever is caused by R. africae. All cases reported to date in France have occurred among patients who came from southern Africa, the endemic zone. We report the first case, to our knowledge, of a patient infected in France.

CASE REPORT

A 69-year-old white man who had never left France developed fever and 3 "black spots" on the legs with lymphangitis and enlarged nodes. The clinically suspected diagnosis was confirmed by positive serology reactions to R. africae. As cross immunity with R. conorii can occur, the diagnosis was further confirmed by western blot for R. africae and by the persistence of the reaction after adsorption of the R. conorii serum.

DISCUSSION

African tick-bite fever was identified as a clinical entity different from Mediterranean spotted fever by Kelly in 1992 who demonstrated the causal role of R. africae. The typical clinical presentation associates fever, several black spots, lymphangitis and multiple node enlargement. The serological diagnosis is difficult owing to cross immunity with R. conorii. Western blot and polymerase chain reaction are required for definitive diagnosis. In our case, the infection was probably due to a R. africae imported into France in the luggage of the patient's daughter who had spent 3 months in Zimbabwe.

Authors+Show Affiliations

Service de Dermatologie, Service d'Anatomopathologie, Hôpital d'Instruction des Armées Desgenettes, Lyon.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

9805550

Citation

Combemale, P, et al. "[African Tick-bite Rickettsiosis: the 1st Case of Autochthonous Infection?]." Annales De Dermatologie Et De Venereologie, vol. 125, no. 9, 1998, pp. 601-3.
Combemale P, Dupin M, Bernard P, et al. [African tick-bite rickettsiosis: the 1st case of autochthonous infection?]. Ann Dermatol Venereol. 1998;125(9):601-3.
Combemale, P., Dupin, M., Bernard, P., Guennoc, B., Saccharin, C., & Tissot-Dupont, H. (1998). [African tick-bite rickettsiosis: the 1st case of autochthonous infection?]. Annales De Dermatologie Et De Venereologie, 125(9), 601-3.
Combemale P, et al. [African Tick-bite Rickettsiosis: the 1st Case of Autochthonous Infection?]. Ann Dermatol Venereol. 1998;125(9):601-3. PubMed PMID: 9805550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [African tick-bite rickettsiosis: the 1st case of autochthonous infection?]. AU - Combemale,P, AU - Dupin,M, AU - Bernard,P, AU - Guennoc,B, AU - Saccharin,C, AU - Tissot-Dupont,H, PY - 1998/11/7/pubmed PY - 1998/11/7/medline PY - 1998/11/7/entrez SP - 601 EP - 3 JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol VL - 125 IS - 9 N2 - BACKGROUND: African tick-bite fever is caused by R. africae. All cases reported to date in France have occurred among patients who came from southern Africa, the endemic zone. We report the first case, to our knowledge, of a patient infected in France. CASE REPORT: A 69-year-old white man who had never left France developed fever and 3 "black spots" on the legs with lymphangitis and enlarged nodes. The clinically suspected diagnosis was confirmed by positive serology reactions to R. africae. As cross immunity with R. conorii can occur, the diagnosis was further confirmed by western blot for R. africae and by the persistence of the reaction after adsorption of the R. conorii serum. DISCUSSION: African tick-bite fever was identified as a clinical entity different from Mediterranean spotted fever by Kelly in 1992 who demonstrated the causal role of R. africae. The typical clinical presentation associates fever, several black spots, lymphangitis and multiple node enlargement. The serological diagnosis is difficult owing to cross immunity with R. conorii. Western blot and polymerase chain reaction are required for definitive diagnosis. In our case, the infection was probably due to a R. africae imported into France in the luggage of the patient's daughter who had spent 3 months in Zimbabwe. SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/9805550/[African_tick_bite_rickettsiosis:_the_1st_case_of_autochthonous_infection]_ L2 - http://www.em-consulte.com/retrieve/pii/MDOI-AD-09-1998-125-9-0151-9638-101019-ART59 DB - PRIME DP - Unbound Medicine ER -