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Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity.
Diabetes Metab. 1998 Sep; 24(4):355-61.DM

Abstract

Obesity is a prevalent metabolic disorder associated with high morbidity and mortality rates. Medical treatment rarely succeeds, and bariatric surgery has been proposed as an alternative therapy. The purpose of this non-controlled retrospective study was to evaluate time-course changes in body weight in severely obese patients who underwent vertical ring gastroplasty or adjustable silicone gastric banding, and to assess the prevalence and potential reversibility of several of the biological abnormalities associated with morbid obesity. From an initial cohort comprising 658 patients, regular body weight measurements and biological data were obtained in 505 patients [419 females, 86 males; age 36 +/- 11 years; body mass index 42.7 +/- 6.9 kg/m2; (mean +/- SD)] with a mean follow-up of 26 +/- 14 months. Mean weight loss was 32 +/- 16 kg. Most weight reduction occurred within the first 6 months, followed by near-stabilisation or even slight weight regain. Most biological parameters were obtained before surgery and after at least 6 months of follow-up. The high prevalence and severity of metabolic disturbances associated with the insulin resistance syndrome (hyperglycaemia, hyperinsulinaemia, decreased HDL cholesterol, hypertriglyceridaemia, elevated fibrinogen levels and hyperuricaemia) before gastroplasty were significantly decreased after weight loss. No major biological deficiencies were observed following gastroplasty, except low iron serum levels. It is concluded that marked weight loss associated with gastroplasty involved a remarkable reduction in the prevalence and severity of several biological abnormalities classically considered as cardiovascular risk factors.

Authors+Show Affiliations

Department of Medicine, CHU Sart Tilman, Liège, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9805647

Citation

Luyckx, F H., et al. "Effects of Gastroplasty On Body Weight and Related Biological Abnormalities in Morbid Obesity." Diabetes & Metabolism, vol. 24, no. 4, 1998, pp. 355-61.
Luyckx FH, Scheen AJ, Desaive C, et al. Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity. Diabetes Metab. 1998;24(4):355-61.
Luyckx, F. H., Scheen, A. J., Desaive, C., Dewe, W., Gielen, J. E., & Lefebvre, P. J. (1998). Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity. Diabetes & Metabolism, 24(4), 355-61.
Luyckx FH, et al. Effects of Gastroplasty On Body Weight and Related Biological Abnormalities in Morbid Obesity. Diabetes Metab. 1998;24(4):355-61. PubMed PMID: 9805647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of gastroplasty on body weight and related biological abnormalities in morbid obesity. AU - Luyckx,F H, AU - Scheen,A J, AU - Desaive,C, AU - Dewe,W, AU - Gielen,J E, AU - Lefebvre,P J, PY - 1998/11/7/pubmed PY - 2000/3/11/medline PY - 1998/11/7/entrez SP - 355 EP - 61 JF - Diabetes & metabolism JO - Diabetes Metab VL - 24 IS - 4 N2 - Obesity is a prevalent metabolic disorder associated with high morbidity and mortality rates. Medical treatment rarely succeeds, and bariatric surgery has been proposed as an alternative therapy. The purpose of this non-controlled retrospective study was to evaluate time-course changes in body weight in severely obese patients who underwent vertical ring gastroplasty or adjustable silicone gastric banding, and to assess the prevalence and potential reversibility of several of the biological abnormalities associated with morbid obesity. From an initial cohort comprising 658 patients, regular body weight measurements and biological data were obtained in 505 patients [419 females, 86 males; age 36 +/- 11 years; body mass index 42.7 +/- 6.9 kg/m2; (mean +/- SD)] with a mean follow-up of 26 +/- 14 months. Mean weight loss was 32 +/- 16 kg. Most weight reduction occurred within the first 6 months, followed by near-stabilisation or even slight weight regain. Most biological parameters were obtained before surgery and after at least 6 months of follow-up. The high prevalence and severity of metabolic disturbances associated with the insulin resistance syndrome (hyperglycaemia, hyperinsulinaemia, decreased HDL cholesterol, hypertriglyceridaemia, elevated fibrinogen levels and hyperuricaemia) before gastroplasty were significantly decreased after weight loss. No major biological deficiencies were observed following gastroplasty, except low iron serum levels. It is concluded that marked weight loss associated with gastroplasty involved a remarkable reduction in the prevalence and severity of several biological abnormalities classically considered as cardiovascular risk factors. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/9805647/Effects_of_gastroplasty_on_body_weight_and_related_biological_abnormalities_in_morbid_obesity_ L2 - http://www.diseaseinfosearch.org/result/9028 DB - PRIME DP - Unbound Medicine ER -