Tags

Type your tag names separated by a space and hit enter

Polymorphism of the apolipoprotein E and angiotensin I converting enzyme genes in Japanese patients with myocardial infarction.
Coron Artery Dis 1998; 9(6):329-34CA

Abstract

OBJECTIVE

To investigate the genetic contribution for myocardial infarction.

METHODS

We investigated common polymorphisms of apolipoprotein E gene and angiotensin converting enzyme (ACE) gene in Japanese population. Subjects were 422 healthy people and 254 patients with myocardial infarction. We evaluated the 287 base pair (bp) insertion (I)/deletion (D) polymorphism in intron 16 of the ACE gene and a polymorphism in the apolipoprotein E gene by using the polymerase chain reaction.

RESULTS

The ACE genotype prevalences for II, ID, and DD were 36.2, 46.1, and 17.7%, respectively, among the myocardial infarction patients. The prevalence of the D allele of the ACE gene among the myocardial infarction patients (0.593) exceeded that among the healthy controls (0.407). The prevalences of the epsilon 2, epsilon 3, and epsilon 4 alleles of the apolipoprotein E genotype among healthy controls were 0.024, 0.882, and 0.094, and those among survivors of myocardial infarction were 0.024, 0.834, and 0.142, respectively. Myocardial infarction patients had an excessive prevalence of the apolipoprotein E epsilon 4 allele (P < 0.05). Multiple regression analysis demonstrated that the independent risk factors for developing myocardial infarction were age, DD genotype of ACE gene, and apolipoprotein E epsilon 4 allele. Stenotic coronary vessels in myocardial infarction patients did not differ significantly among the patients with various ACE and apolipoprotein E genotypes in the present study.

CONCLUSIONS

Among the Japanese, apolipoprotein E epsilon 4 carriers and subjects with ACE DD genotype are at an increased risk of myocardial infarction.

Authors+Show Affiliations

Second Department of Internal Medicine, Iwate Medical University, Morioka, Japan. knakai@iwate-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9812182

Citation

Nakai, K, et al. "Polymorphism of the Apolipoprotein E and Angiotensin I Converting Enzyme Genes in Japanese Patients With Myocardial Infarction." Coronary Artery Disease, vol. 9, no. 6, 1998, pp. 329-34.
Nakai K, Fusazaki T, Zhang T, et al. Polymorphism of the apolipoprotein E and angiotensin I converting enzyme genes in Japanese patients with myocardial infarction. Coron Artery Dis. 1998;9(6):329-34.
Nakai, K., Fusazaki, T., Zhang, T., Shiroto, T., Osawa, M., Kamata, J., ... Hiramori, K. (1998). Polymorphism of the apolipoprotein E and angiotensin I converting enzyme genes in Japanese patients with myocardial infarction. Coronary Artery Disease, 9(6), pp. 329-34.
Nakai K, et al. Polymorphism of the Apolipoprotein E and Angiotensin I Converting Enzyme Genes in Japanese Patients With Myocardial Infarction. Coron Artery Dis. 1998;9(6):329-34. PubMed PMID: 9812182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphism of the apolipoprotein E and angiotensin I converting enzyme genes in Japanese patients with myocardial infarction. AU - Nakai,K, AU - Fusazaki,T, AU - Zhang,T, AU - Shiroto,T, AU - Osawa,M, AU - Kamata,J, AU - Itoh,M, AU - Nakai,K, AU - Habano,W, AU - Kiuchi,T, AU - Yamamori,S, AU - Hiramori,K, PY - 1998/11/13/pubmed PY - 1998/11/13/medline PY - 1998/11/13/entrez SP - 329 EP - 34 JF - Coronary artery disease JO - Coron. Artery Dis. VL - 9 IS - 6 N2 - OBJECTIVE: To investigate the genetic contribution for myocardial infarction. METHODS: We investigated common polymorphisms of apolipoprotein E gene and angiotensin converting enzyme (ACE) gene in Japanese population. Subjects were 422 healthy people and 254 patients with myocardial infarction. We evaluated the 287 base pair (bp) insertion (I)/deletion (D) polymorphism in intron 16 of the ACE gene and a polymorphism in the apolipoprotein E gene by using the polymerase chain reaction. RESULTS: The ACE genotype prevalences for II, ID, and DD were 36.2, 46.1, and 17.7%, respectively, among the myocardial infarction patients. The prevalence of the D allele of the ACE gene among the myocardial infarction patients (0.593) exceeded that among the healthy controls (0.407). The prevalences of the epsilon 2, epsilon 3, and epsilon 4 alleles of the apolipoprotein E genotype among healthy controls were 0.024, 0.882, and 0.094, and those among survivors of myocardial infarction were 0.024, 0.834, and 0.142, respectively. Myocardial infarction patients had an excessive prevalence of the apolipoprotein E epsilon 4 allele (P < 0.05). Multiple regression analysis demonstrated that the independent risk factors for developing myocardial infarction were age, DD genotype of ACE gene, and apolipoprotein E epsilon 4 allele. Stenotic coronary vessels in myocardial infarction patients did not differ significantly among the patients with various ACE and apolipoprotein E genotypes in the present study. CONCLUSIONS: Among the Japanese, apolipoprotein E epsilon 4 carriers and subjects with ACE DD genotype are at an increased risk of myocardial infarction. SN - 0954-6928 UR - https://www.unboundmedicine.com/medline/citation/9812182/Polymorphism_of_the_apolipoprotein_E_and_angiotensin_I_converting_enzyme_genes_in_Japanese_patients_with_myocardial_infarction_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9812182.ui DB - PRIME DP - Unbound Medicine ER -