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Effects of 7-bromoethoxybenzene-tetrahydropalmatine on voltage-dependent currents in guinea pig ventricular myocytes.
Zhongguo Yao Li Xue Bao. 1996 May; 17(3):227-9.ZY

Abstract

AIM

To study the anti-arrhythmic mechanism of 7-bromoethoxybenzene-tetrahydropalmatine (EBP).

METHODS

Whole-cell current and voltage clamp on isolated guinea pig ventricular cells.

RESULTS

EBP 30 mumol.L-1 prolonged APD90 from 430 +/- 47 ms to 514 +/- 61 ms (n = 5, P < 0.05) without effects on the action potential amplitude and resting potential. Delayed outward K+ current and its tail current were blocked by EBP in a concentration-dependent fashion, while EBP did not change the amplitudes of the sodium current, the L type calcium current, and the inwardly rectifying potassium current.

CONCLUSION

The mechanism of anti-arrhythmic action of EBP was to prolong the APD through inhibiting the delayed rectified potassium current.

Authors+Show Affiliations

Institute of Biophysics & Biochemistry, Huazhong University of Science & Technology, Wuhan 430074, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9812742

Citation

Niu, X W., et al. "Effects of 7-bromoethoxybenzene-tetrahydropalmatine On Voltage-dependent Currents in Guinea Pig Ventricular Myocytes." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 17, no. 3, 1996, pp. 227-9.
Niu XW, Zeng T, Qu AL, et al. Effects of 7-bromoethoxybenzene-tetrahydropalmatine on voltage-dependent currents in guinea pig ventricular myocytes. Zhongguo Yao Li Xue Bao. 1996;17(3):227-9.
Niu, X. W., Zeng, T., Qu, A. L., Kang, H. G., Dai, S. P., Yao, W. X., & Jiang, M. X. (1996). Effects of 7-bromoethoxybenzene-tetrahydropalmatine on voltage-dependent currents in guinea pig ventricular myocytes. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 17(3), 227-9.
Niu XW, et al. Effects of 7-bromoethoxybenzene-tetrahydropalmatine On Voltage-dependent Currents in Guinea Pig Ventricular Myocytes. Zhongguo Yao Li Xue Bao. 1996;17(3):227-9. PubMed PMID: 9812742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of 7-bromoethoxybenzene-tetrahydropalmatine on voltage-dependent currents in guinea pig ventricular myocytes. AU - Niu,X W, AU - Zeng,T, AU - Qu,A L, AU - Kang,H G, AU - Dai,S P, AU - Yao,W X, AU - Jiang,M X, PY - 1996/5/1/pubmed PY - 1998/11/13/medline PY - 1996/5/1/entrez SP - 227 EP - 9 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 17 IS - 3 N2 - AIM: To study the anti-arrhythmic mechanism of 7-bromoethoxybenzene-tetrahydropalmatine (EBP). METHODS: Whole-cell current and voltage clamp on isolated guinea pig ventricular cells. RESULTS: EBP 30 mumol.L-1 prolonged APD90 from 430 +/- 47 ms to 514 +/- 61 ms (n = 5, P < 0.05) without effects on the action potential amplitude and resting potential. Delayed outward K+ current and its tail current were blocked by EBP in a concentration-dependent fashion, while EBP did not change the amplitudes of the sodium current, the L type calcium current, and the inwardly rectifying potassium current. CONCLUSION: The mechanism of anti-arrhythmic action of EBP was to prolong the APD through inhibiting the delayed rectified potassium current. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/9812742/Effects_of_7_bromoethoxybenzene_tetrahydropalmatine_on_voltage_dependent_currents_in_guinea_pig_ventricular_myocytes_ L2 - http://www.chinaphar.com/1671-4083/17/227.pdf DB - PRIME DP - Unbound Medicine ER -