Tags

Type your tag names separated by a space and hit enter

[Role of KATP channels in the cardioprotection provided by ischemic preconditioning in anesthetized rabbits].
Sheng Li Xue Bao. 1997 Feb; 49(1):105-9.SL

Abstract

The effects of KATP channel opener cromaklim (Cro) and ischemic preconditioning (IP) on hemodynamics and myocardial infarct size were examined in both urethane and sodium pentobarbital anesthetized rabbit models of myocardial ischemia-reperfusion to determine whether the KATP channel was involved in the cardioprotection provided by IP. The results were as follows: (1) All hemodynamic parameters and myocardial oxygen consumption were decreased progressively during the course of ischemia (30 min)-reperfusion (180 min). (2) In the urethane anesthetized model, the myocardial infarct size of the left ventricle induced by ischemia-reperfusion was (32.3 +/- 0.8)%. Pretreatment with Cro reduced the myocardial infarct size to (23.3 +/- 2.2)%, while IP significantly reduced the infarct size to (21.6 +/- 1.8)%, which was abolished by a potent KATP channel blocker glibenclamide. (3) In the sodium pentobarbital anesthetized model, myocardial infarct size was (32.7 +/- 1.0)%. IP also reduced the myocardial infarct size to (19.7 +/- 1.5)%, which could not be blocked by cardioprotection of IP by glibenclamide. Cro failed to decrease infarct size. Such results indicated that activation of KATP channels exerted a beneficial action on ischemia-reperfused myocardium only in the urethane anesthetized rabbit.

Authors+Show Affiliations

Department of Physiology, Hebei Medical University, Shijiazhuang.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

9812842

Citation

Ding, Y F., and R R. He. "[Role of KATP Channels in the Cardioprotection Provided By Ischemic Preconditioning in Anesthetized Rabbits]." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 49, no. 1, 1997, pp. 105-9.
Ding YF, He RR. [Role of KATP channels in the cardioprotection provided by ischemic preconditioning in anesthetized rabbits]. Sheng Li Xue Bao. 1997;49(1):105-9.
Ding, Y. F., & He, R. R. (1997). [Role of KATP channels in the cardioprotection provided by ischemic preconditioning in anesthetized rabbits]. Sheng Li Xue Bao : [Acta Physiologica Sinica], 49(1), 105-9.
Ding YF, He RR. [Role of KATP Channels in the Cardioprotection Provided By Ischemic Preconditioning in Anesthetized Rabbits]. Sheng Li Xue Bao. 1997;49(1):105-9. PubMed PMID: 9812842.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of KATP channels in the cardioprotection provided by ischemic preconditioning in anesthetized rabbits]. AU - Ding,Y F, AU - He,R R, PY - 1997/2/1/pubmed PY - 1998/11/13/medline PY - 1997/2/1/entrez SP - 105 EP - 9 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 49 IS - 1 N2 - The effects of KATP channel opener cromaklim (Cro) and ischemic preconditioning (IP) on hemodynamics and myocardial infarct size were examined in both urethane and sodium pentobarbital anesthetized rabbit models of myocardial ischemia-reperfusion to determine whether the KATP channel was involved in the cardioprotection provided by IP. The results were as follows: (1) All hemodynamic parameters and myocardial oxygen consumption were decreased progressively during the course of ischemia (30 min)-reperfusion (180 min). (2) In the urethane anesthetized model, the myocardial infarct size of the left ventricle induced by ischemia-reperfusion was (32.3 +/- 0.8)%. Pretreatment with Cro reduced the myocardial infarct size to (23.3 +/- 2.2)%, while IP significantly reduced the infarct size to (21.6 +/- 1.8)%, which was abolished by a potent KATP channel blocker glibenclamide. (3) In the sodium pentobarbital anesthetized model, myocardial infarct size was (32.7 +/- 1.0)%. IP also reduced the myocardial infarct size to (19.7 +/- 1.5)%, which could not be blocked by cardioprotection of IP by glibenclamide. Cro failed to decrease infarct size. Such results indicated that activation of KATP channels exerted a beneficial action on ischemia-reperfused myocardium only in the urethane anesthetized rabbit. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/9812842/[Role_of_KATP_channels_in_the_cardioprotection_provided_by_ischemic_preconditioning_in_anesthetized_rabbits]_ L2 - https://medlineplus.gov/heartattack.html DB - PRIME DP - Unbound Medicine ER -