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Telomerase activity in pancreatic juice differentiates ductal carcinoma from adenoma and pancreatitis.
Clin Cancer Res. 1997 Dec; 3(12 Pt 1):2479-83.CC

Abstract

Telomerase activity was measured in pancreatic juice obtained by endoscopic retrograde pancreatography from 34 patients (12 with ductal carcinoma, 12 with pancreatic adenoma, and 10 with pancreatitis). The activity in pancreatic juice was expressed as the number of cells of a human pancreatic cancer cell line, MIA PaCa-2, that exhibit an activity equal to that expressed in 1 microg of protein from pancreatic juice. A telomerase ladder was detected in the pancreatic juice obtained from a majority of the patients with ductal adenocarcinoma. The median value of relative telomerase activity in the carcinoma samples was 9.38 (25th percentile, 3.14; 75th percentile, 95.8), a value significantly higher than that derived from patients with either pancreatitis or pancreatic adenoma (P < 0.0001). When a threshold value of relative telomerase activity of 3.00 was used, 75% (9 of 12) of the samples obtained from patients with ductal carcinoma were positive. We conclude that telomerase activity in pancreatic juice differentiates adenocarcinoma from adenoma and pancreatitis and may serve as a useful diagnostic tool.

Authors+Show Affiliations

Departments of Surgery, Kyushu University Faculty of Medicine, Fukuoka 812-82, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9815650

Citation

Suehara, N, et al. "Telomerase Activity in Pancreatic Juice Differentiates Ductal Carcinoma From Adenoma and Pancreatitis." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 3, no. 12 Pt 1, 1997, pp. 2479-83.
Suehara N, Mizumoto K, Tanaka M, et al. Telomerase activity in pancreatic juice differentiates ductal carcinoma from adenoma and pancreatitis. Clin Cancer Res. 1997;3(12 Pt 1):2479-83.
Suehara, N., Mizumoto, K., Tanaka, M., Niiyama, H., Yokohata, K., Tominaga, Y., Shimura, H., Muta, T., & Hamasaki, N. (1997). Telomerase activity in pancreatic juice differentiates ductal carcinoma from adenoma and pancreatitis. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 3(12 Pt 1), 2479-83.
Suehara N, et al. Telomerase Activity in Pancreatic Juice Differentiates Ductal Carcinoma From Adenoma and Pancreatitis. Clin Cancer Res. 1997;3(12 Pt 1):2479-83. PubMed PMID: 9815650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomerase activity in pancreatic juice differentiates ductal carcinoma from adenoma and pancreatitis. AU - Suehara,N, AU - Mizumoto,K, AU - Tanaka,M, AU - Niiyama,H, AU - Yokohata,K, AU - Tominaga,Y, AU - Shimura,H, AU - Muta,T, AU - Hamasaki,N, PY - 1998/11/17/pubmed PY - 1998/11/17/medline PY - 1998/11/17/entrez SP - 2479 EP - 83 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin. Cancer Res. VL - 3 IS - 12 Pt 1 N2 - Telomerase activity was measured in pancreatic juice obtained by endoscopic retrograde pancreatography from 34 patients (12 with ductal carcinoma, 12 with pancreatic adenoma, and 10 with pancreatitis). The activity in pancreatic juice was expressed as the number of cells of a human pancreatic cancer cell line, MIA PaCa-2, that exhibit an activity equal to that expressed in 1 microg of protein from pancreatic juice. A telomerase ladder was detected in the pancreatic juice obtained from a majority of the patients with ductal adenocarcinoma. The median value of relative telomerase activity in the carcinoma samples was 9.38 (25th percentile, 3.14; 75th percentile, 95.8), a value significantly higher than that derived from patients with either pancreatitis or pancreatic adenoma (P < 0.0001). When a threshold value of relative telomerase activity of 3.00 was used, 75% (9 of 12) of the samples obtained from patients with ductal carcinoma were positive. We conclude that telomerase activity in pancreatic juice differentiates adenocarcinoma from adenoma and pancreatitis and may serve as a useful diagnostic tool. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/9815650/Telomerase_activity_in_pancreatic_juice_differentiates_ductal_carcinoma_from_adenoma_and_pancreatitis_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=9815650 DB - PRIME DP - Unbound Medicine ER -