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Patterns of DNA ploidy and S-phase fraction associated with breast cancer survival in blacks and whites.
Clin Cancer Res. 1997 Apr; 3(4):587-92.CC

Abstract

A significant survival difference between black and white breast cancer patients has been observed in the United States. Evaluation of the prognostic value of DNA ploidy and S-phase fraction (SPF) in black and white breast cancer patients may contribute to our understanding of the mechanisms of racial disparity in survival. A sample of 98 patients (50 blacks and 48 whites) who participated in the Black/White Cancer Survival Study was selected for DNA flow cytometry analysis. Patients were followed between 4.5 and 6.5 years. The impacts of DNA ploidy and SPF on breast cancer survival were examined. Kaplan-Meier survival curves, log rank statistics, and Cox proportional hazards regression were used for survival analyses. Black patients were more likely than white patients to have tumors with high SPF (P < 0.05), but there was no difference in DNA ploidy (P = 0.79). Because there were significant interactions of both DNA ploidy and SPF with race, survival was examined separately for blacks and whites. Significantly poorer survival was observed for white patients with class A ploidy (hypodiploidy, hypotetraploidy, and hypertetraploidy; P = 0.001) and with high SPF (P = 0.025). The elevated hazard ratios remained significant after adjusting for age and stage. Further adjustment for adjuvant therapy and histopathological characteristics of tumor reduced the hazard ratios of SPF to a nonsignificant level. No significant associations were found between survival and DNA ploidy or SPF among blacks. DNA ploidy and SPF are prognostic factors for breast cancer survival in white patients but not in blacks. This may have clinical implication in breast cancer management.

Authors+Show Affiliations

Laboratory of Comparative Carcinogenesis, National Cancer Institute-Frederick Cancer Research and Development Center, NIH, Frederick, Maryland 21702, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9815724

Citation

Shiao, Y H., et al. "Patterns of DNA Ploidy and S-phase Fraction Associated With Breast Cancer Survival in Blacks and Whites." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 3, no. 4, 1997, pp. 587-92.
Shiao YH, Chen VW, Lehmann HP, et al. Patterns of DNA ploidy and S-phase fraction associated with breast cancer survival in blacks and whites. Clin Cancer Res. 1997;3(4):587-92.
Shiao, Y. H., Chen, V. W., Lehmann, H. P., Wu, X. C., & Correa, P. (1997). Patterns of DNA ploidy and S-phase fraction associated with breast cancer survival in blacks and whites. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 3(4), 587-92.
Shiao YH, et al. Patterns of DNA Ploidy and S-phase Fraction Associated With Breast Cancer Survival in Blacks and Whites. Clin Cancer Res. 1997;3(4):587-92. PubMed PMID: 9815724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patterns of DNA ploidy and S-phase fraction associated with breast cancer survival in blacks and whites. AU - Shiao,Y H, AU - Chen,V W, AU - Lehmann,H P, AU - Wu,X C, AU - Correa,P, PY - 1997/4/1/pubmed PY - 1998/11/17/medline PY - 1997/4/1/entrez SP - 587 EP - 92 JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 3 IS - 4 N2 - A significant survival difference between black and white breast cancer patients has been observed in the United States. Evaluation of the prognostic value of DNA ploidy and S-phase fraction (SPF) in black and white breast cancer patients may contribute to our understanding of the mechanisms of racial disparity in survival. A sample of 98 patients (50 blacks and 48 whites) who participated in the Black/White Cancer Survival Study was selected for DNA flow cytometry analysis. Patients were followed between 4.5 and 6.5 years. The impacts of DNA ploidy and SPF on breast cancer survival were examined. Kaplan-Meier survival curves, log rank statistics, and Cox proportional hazards regression were used for survival analyses. Black patients were more likely than white patients to have tumors with high SPF (P < 0.05), but there was no difference in DNA ploidy (P = 0.79). Because there were significant interactions of both DNA ploidy and SPF with race, survival was examined separately for blacks and whites. Significantly poorer survival was observed for white patients with class A ploidy (hypodiploidy, hypotetraploidy, and hypertetraploidy; P = 0.001) and with high SPF (P = 0.025). The elevated hazard ratios remained significant after adjusting for age and stage. Further adjustment for adjuvant therapy and histopathological characteristics of tumor reduced the hazard ratios of SPF to a nonsignificant level. No significant associations were found between survival and DNA ploidy or SPF among blacks. DNA ploidy and SPF are prognostic factors for breast cancer survival in white patients but not in blacks. This may have clinical implication in breast cancer management. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/9815724/Patterns_of_DNA_ploidy_and_S_phase_fraction_associated_with_breast_cancer_survival_in_blacks_and_whites_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=9815724 DB - PRIME DP - Unbound Medicine ER -