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Blue-on-yellow visual field and retinal nerve fiber layer in ocular hypertension and glaucoma.
Ophthalmology. 1998 Nov; 105(11):2077-81.O

Abstract

BACKGROUND AND OBJECTIVE

It has been suggested that the clinically detectable changes of the blue-on-yellow (B/Y) visual field and retinal nerve fiber layer (RNFL) may precede standard white-on-white (W/W) visual field defects in the progression of glaucoma. The aim of this study was to test the relationship between the results of B/Y visual fields and semiquantitative RNFL evaluation in corresponding areas and to determine how the B/Y visual fields and RNFL scores label the normal W/W perimetry hemifields in patients with glaucoma and ocular hypertension.

DESIGN

A cohort study.

PARTICIPANTS AND METHODS

Monochromatic RNFL photographs of 32 normal subjects and 29 patients with ocular hypertension and different stages of glaucoma were assessed in a masked fashion. The B/Y and W/W visual fields (program 30-2) were examined with a Humphrey perimeter. The results of both visual fields were adjusted for the patients' age and lens transmission index measured with a lens fluorometer.

MAIN OUTCOME MEASURE

Mean deviation (MD) of visual field and semiquantitative score of RNFL loss were measured.

RESULTS

The total and hemifield MD values of B/Y and W/W visual field showed a statistically significant correlation with diffuse and overall score of RNFL loss in corresponding areas. The hemifield MD values of B/Y perimetry obtained from "normal" W/W hemifields of patients with early glaucoma were well correlated (r = -0.56) with respective RNFL loss scores found to be abnormal in 84% of hemispheres. The difference between the hemifield MD values of B/Y perimetry obtained from normal W/WAN hemifields of patients with ocular hypertension and patients with early glaucoma was not statistically significant (analysis of variance). The respective B/Y hemifield data of normal subjects were statistically significantly different from the data of patients with ocular hypertension and early glaucoma.

CONCLUSIONS

The hemifield MD values of B/Y perimetry correlate well with semiquantitative scores of RNFL loss obtained from the corresponding hemisphere. The B/Y perimetry as well as RNFL assessment may show glaucomatous defects in a hemifield found to be normal on W/W perimetry. In subjects with ocular hypertension, the functional damage detected by B/Y perimetry may, in some cases, precede RNFL defects on conversion to glaucoma.

Authors+Show Affiliations

Department of Ophthalmology, University of Oulu, Finland.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9818609

Citation

Teesalu, P, et al. "Blue-on-yellow Visual Field and Retinal Nerve Fiber Layer in Ocular Hypertension and Glaucoma." Ophthalmology, vol. 105, no. 11, 1998, pp. 2077-81.
Teesalu P, Airaksinen PJ, Tuulonen A. Blue-on-yellow visual field and retinal nerve fiber layer in ocular hypertension and glaucoma. Ophthalmology. 1998;105(11):2077-81.
Teesalu, P., Airaksinen, P. J., & Tuulonen, A. (1998). Blue-on-yellow visual field and retinal nerve fiber layer in ocular hypertension and glaucoma. Ophthalmology, 105(11), 2077-81.
Teesalu P, Airaksinen PJ, Tuulonen A. Blue-on-yellow Visual Field and Retinal Nerve Fiber Layer in Ocular Hypertension and Glaucoma. Ophthalmology. 1998;105(11):2077-81. PubMed PMID: 9818609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blue-on-yellow visual field and retinal nerve fiber layer in ocular hypertension and glaucoma. AU - Teesalu,P, AU - Airaksinen,P J, AU - Tuulonen,A, PY - 1998/11/18/pubmed PY - 1998/11/18/medline PY - 1998/11/18/entrez SP - 2077 EP - 81 JF - Ophthalmology JO - Ophthalmology VL - 105 IS - 11 N2 - BACKGROUND AND OBJECTIVE: It has been suggested that the clinically detectable changes of the blue-on-yellow (B/Y) visual field and retinal nerve fiber layer (RNFL) may precede standard white-on-white (W/W) visual field defects in the progression of glaucoma. The aim of this study was to test the relationship between the results of B/Y visual fields and semiquantitative RNFL evaluation in corresponding areas and to determine how the B/Y visual fields and RNFL scores label the normal W/W perimetry hemifields in patients with glaucoma and ocular hypertension. DESIGN: A cohort study. PARTICIPANTS AND METHODS: Monochromatic RNFL photographs of 32 normal subjects and 29 patients with ocular hypertension and different stages of glaucoma were assessed in a masked fashion. The B/Y and W/W visual fields (program 30-2) were examined with a Humphrey perimeter. The results of both visual fields were adjusted for the patients' age and lens transmission index measured with a lens fluorometer. MAIN OUTCOME MEASURE: Mean deviation (MD) of visual field and semiquantitative score of RNFL loss were measured. RESULTS: The total and hemifield MD values of B/Y and W/W visual field showed a statistically significant correlation with diffuse and overall score of RNFL loss in corresponding areas. The hemifield MD values of B/Y perimetry obtained from "normal" W/W hemifields of patients with early glaucoma were well correlated (r = -0.56) with respective RNFL loss scores found to be abnormal in 84% of hemispheres. The difference between the hemifield MD values of B/Y perimetry obtained from normal W/WAN hemifields of patients with ocular hypertension and patients with early glaucoma was not statistically significant (analysis of variance). The respective B/Y hemifield data of normal subjects were statistically significantly different from the data of patients with ocular hypertension and early glaucoma. CONCLUSIONS: The hemifield MD values of B/Y perimetry correlate well with semiquantitative scores of RNFL loss obtained from the corresponding hemisphere. The B/Y perimetry as well as RNFL assessment may show glaucomatous defects in a hemifield found to be normal on W/W perimetry. In subjects with ocular hypertension, the functional damage detected by B/Y perimetry may, in some cases, precede RNFL defects on conversion to glaucoma. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/9818609/Blue_on_yellow_visual_field_and_retinal_nerve_fiber_layer_in_ocular_hypertension_and_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(98)91128-9 DB - PRIME DP - Unbound Medicine ER -