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Renal involvement in Behçet's disease: review of 9 cases.
J Rheumatol. 1998 Nov; 25(11):2254-60.JR

Abstract

We describe clinical data on 9 patients with Behçet's disease with renal involvement (8 males, one female) and results of kidney biopsies in 4 patients. Renal involvement occurred in 9 of 120 patients (7.5%) followed at our center. Proteinuria was present in 8 patients (6 with quantitative 24 h urine protein with a range of 0.32-3.11 g/day, mean 1.7 g/day); hematuria occurred in one patient. Impaired renal function was encountered in 2 patients at presentation and in another patient at a later date. Major vascular involvement (major venous and/or arterial thrombosis) was present in 4 patients and sagittal sinus thrombosis in another patient. Measurement of complement C3, C4, and CH50 and immunologic tests for anticardiolipin, antineutrophil cytoplasmic, and antistreptococcal antibodies did not indicate a clear association with renal involvement. Kidney biopsies were performed in 4 patients. Mesangial proliferative changes were observed in 3 patients and evidence of immune complex deposition by immunofluorescence and electron microscopic examination was present in 2 patients. Amyloidosis was present in one patient who had vascular involvement and presented with nephrotic range proteinuria.

Authors+Show Affiliations

Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

9818673

Citation

El Ramahi, K M., et al. "Renal Involvement in Behçet's Disease: Review of 9 Cases." The Journal of Rheumatology, vol. 25, no. 11, 1998, pp. 2254-60.
El Ramahi KM, Al Dalaan A, Al Shaikh A, et al. Renal involvement in Behçet's disease: review of 9 cases. J Rheumatol. 1998;25(11):2254-60.
El Ramahi, K. M., Al Dalaan, A., Al Shaikh, A., Al Meshari, K., & Akhtar, M. (1998). Renal involvement in Behçet's disease: review of 9 cases. The Journal of Rheumatology, 25(11), 2254-60.
El Ramahi KM, et al. Renal Involvement in Behçet's Disease: Review of 9 Cases. J Rheumatol. 1998;25(11):2254-60. PubMed PMID: 9818673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal involvement in Behçet's disease: review of 9 cases. AU - El Ramahi,K M, AU - Al Dalaan,A, AU - Al Shaikh,A, AU - Al Meshari,K, AU - Akhtar,M, PY - 1998/11/18/pubmed PY - 1998/11/18/medline PY - 1998/11/18/entrez SP - 2254 EP - 60 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 25 IS - 11 N2 - We describe clinical data on 9 patients with Behçet's disease with renal involvement (8 males, one female) and results of kidney biopsies in 4 patients. Renal involvement occurred in 9 of 120 patients (7.5%) followed at our center. Proteinuria was present in 8 patients (6 with quantitative 24 h urine protein with a range of 0.32-3.11 g/day, mean 1.7 g/day); hematuria occurred in one patient. Impaired renal function was encountered in 2 patients at presentation and in another patient at a later date. Major vascular involvement (major venous and/or arterial thrombosis) was present in 4 patients and sagittal sinus thrombosis in another patient. Measurement of complement C3, C4, and CH50 and immunologic tests for anticardiolipin, antineutrophil cytoplasmic, and antistreptococcal antibodies did not indicate a clear association with renal involvement. Kidney biopsies were performed in 4 patients. Mesangial proliferative changes were observed in 3 patients and evidence of immune complex deposition by immunofluorescence and electron microscopic examination was present in 2 patients. Amyloidosis was present in one patient who had vascular involvement and presented with nephrotic range proteinuria. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/9818673/Renal_involvement_in_Behçet's_disease:_review_of_9_cases_ L2 - http://www.diseaseinfosearch.org/result/780 DB - PRIME DP - Unbound Medicine ER -