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Comparative efficacy of a single daily dose of two capsules Cyclo 3 Fort in the morning versus a repeated dose of one capsule morning and noon. A one-month study.
Int Angiol. 1998 Sep; 17(3):155-60.IA

Abstract

BACKGROUND

The efficacy of Cyclo 3 Fort has previously been demonstrated in placebo-controlled trials on plethysmographic and clinical parameters. Its objective was to demonstrate that after one month of therapy, the efficacy and safety of a single dose of two capsules of Cyclo 3 Fort in the morning were comparable to that of a twice daily dose of Cyclo 3 Fort, one capsule morning and noon.

METHODS

This single-center, randomised, double-blind study was conducted on 37 women with chronic lower-limb venous insufficiency, associating clinical or functional signs and abnormal plethysmographic values. Clinical parameters measured were those conventionally used to assess superficial venous insufficiency; the main laboratory parameter evaluated by plethysmography was the index of venous distensibility.

RESULTS

The results data show that in each of the study groups, all of the patients attained a significant improvement in their clinical conditions, confirmed by laboratory tests, following one month of therapy with Cyclo 3 Fort. On the other hand, comparison of results data between the two groups did not objectify any significant difference between the two treatment modalities.

CONCLUSIONS

Thus a single dose of two capsules of Cyclo 3 Fort in the morning appears as effective and as well-tolerated as a twice daily dose of one capsule of Cyclo 3 Fort morning and noon.

Authors+Show Affiliations

Service d'Angiologie, CHU Rangueil, Toulouse, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9821028

Citation

Boccalon, H, et al. "Comparative Efficacy of a Single Daily Dose of Two Capsules Cyclo 3 Fort in the Morning Versus a Repeated Dose of One Capsule Morning and Noon. a One-month Study." International Angiology : a Journal of the International Union of Angiology, vol. 17, no. 3, 1998, pp. 155-60.
Boccalon H, Causse C, Yubero L. Comparative efficacy of a single daily dose of two capsules Cyclo 3 Fort in the morning versus a repeated dose of one capsule morning and noon. A one-month study. Int Angiol. 1998;17(3):155-60.
Boccalon, H., Causse, C., & Yubero, L. (1998). Comparative efficacy of a single daily dose of two capsules Cyclo 3 Fort in the morning versus a repeated dose of one capsule morning and noon. A one-month study. International Angiology : a Journal of the International Union of Angiology, 17(3), 155-60.
Boccalon H, Causse C, Yubero L. Comparative Efficacy of a Single Daily Dose of Two Capsules Cyclo 3 Fort in the Morning Versus a Repeated Dose of One Capsule Morning and Noon. a One-month Study. Int Angiol. 1998;17(3):155-60. PubMed PMID: 9821028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative efficacy of a single daily dose of two capsules Cyclo 3 Fort in the morning versus a repeated dose of one capsule morning and noon. A one-month study. AU - Boccalon,H, AU - Causse,C, AU - Yubero,L, PY - 1998/11/20/pubmed PY - 1998/11/20/medline PY - 1998/11/20/entrez SP - 155 EP - 60 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 17 IS - 3 N2 - BACKGROUND: The efficacy of Cyclo 3 Fort has previously been demonstrated in placebo-controlled trials on plethysmographic and clinical parameters. Its objective was to demonstrate that after one month of therapy, the efficacy and safety of a single dose of two capsules of Cyclo 3 Fort in the morning were comparable to that of a twice daily dose of Cyclo 3 Fort, one capsule morning and noon. METHODS: This single-center, randomised, double-blind study was conducted on 37 women with chronic lower-limb venous insufficiency, associating clinical or functional signs and abnormal plethysmographic values. Clinical parameters measured were those conventionally used to assess superficial venous insufficiency; the main laboratory parameter evaluated by plethysmography was the index of venous distensibility. RESULTS: The results data show that in each of the study groups, all of the patients attained a significant improvement in their clinical conditions, confirmed by laboratory tests, following one month of therapy with Cyclo 3 Fort. On the other hand, comparison of results data between the two groups did not objectify any significant difference between the two treatment modalities. CONCLUSIONS: Thus a single dose of two capsules of Cyclo 3 Fort in the morning appears as effective and as well-tolerated as a twice daily dose of one capsule of Cyclo 3 Fort morning and noon. SN - 0392-9590 UR - https://www.unboundmedicine.com/medline/citation/9821028/Comparative_efficacy_of_a_single_daily_dose_of_two_capsules_Cyclo_3_Fort_in_the_morning_versus_a_repeated_dose_of_one_capsule_morning_and_noon__A_one_month_study_ DB - PRIME DP - Unbound Medicine ER -