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Use of oral contraceptives and risk of breast cancer in young women.
Breast Cancer Res Treat 1998; 50(2):175-84BC

Abstract

Many studies have shown that oral contraceptive (OC) use increases a young woman's risk of breast cancer, although some studies suggest that the risk may be limited to recent use. The objective of this study was to determine what particular aspects of OC use could be important for breast cancer development at an early age in the cohort of women who had the opportunity to use OCs all of their reproductive life. The cases were first diagnosed with breast cancer at age 40 or younger between 1983 and 1988, and identified by the Los Angeles County Cancer Surveillance Program. Control subjects were individually matched to participating cases on birth date (within 36 months), race (white), parity (nulliparous versus parous), and neighborhood of residence. Detailed OC histories were obtained during in-person interviews with subjects. In general the risk estimates were small, and not statistically significant. Compared to no use, having used OCs for 12 years or more was associated with a modest non-significant elevated breast cancer risk with an odds ratio (OR) of 1.4 (95% confidence interval (CI) = 0.8-2.4). Long-term (12 years or more) users of high-dose estrogen pills had a non-significant 60% higher breast cancer risk than never users (CI = 0.9-3.2). Early use was associated with slightly higher ORs among young women (age < or =35), and among parous women. Recent use was associated with somewhat higher ORs among parous women and women above age 36. Analyses by stage, body weight, and family history yielded similar results. This study is consistent with a modest effect of early OC use on breast cancer risk in young women.

Authors+Show Affiliations

Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles 90033-0800, USA. gursin@hsc.usc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9822222

Citation

Ursin, G, et al. "Use of Oral Contraceptives and Risk of Breast Cancer in Young Women." Breast Cancer Research and Treatment, vol. 50, no. 2, 1998, pp. 175-84.
Ursin G, Ross RK, Sullivan-Halley J, et al. Use of oral contraceptives and risk of breast cancer in young women. Breast Cancer Res Treat. 1998;50(2):175-84.
Ursin, G., Ross, R. K., Sullivan-Halley, J., Hanisch, R., Henderson, B., & Bernstein, L. (1998). Use of oral contraceptives and risk of breast cancer in young women. Breast Cancer Research and Treatment, 50(2), pp. 175-84.
Ursin G, et al. Use of Oral Contraceptives and Risk of Breast Cancer in Young Women. Breast Cancer Res Treat. 1998;50(2):175-84. PubMed PMID: 9822222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of oral contraceptives and risk of breast cancer in young women. AU - Ursin,G, AU - Ross,R K, AU - Sullivan-Halley,J, AU - Hanisch,R, AU - Henderson,B, AU - Bernstein,L, PY - 1998/11/20/pubmed PY - 1998/11/20/medline PY - 1998/11/20/entrez KW - Age Factors KW - Americas KW - Biology KW - Breast Cancer KW - California KW - Cancer KW - Case Control Studies KW - Contraception KW - Contraceptive Methods--side effects KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Family Planning KW - Longterm Effects KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives--side effects KW - Population KW - Population Characteristics KW - Population Dynamics KW - Research Methodology KW - Research Report KW - Risk Factors KW - Studies KW - Time Factors KW - United States SP - 175 EP - 84 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 50 IS - 2 N2 - Many studies have shown that oral contraceptive (OC) use increases a young woman's risk of breast cancer, although some studies suggest that the risk may be limited to recent use. The objective of this study was to determine what particular aspects of OC use could be important for breast cancer development at an early age in the cohort of women who had the opportunity to use OCs all of their reproductive life. The cases were first diagnosed with breast cancer at age 40 or younger between 1983 and 1988, and identified by the Los Angeles County Cancer Surveillance Program. Control subjects were individually matched to participating cases on birth date (within 36 months), race (white), parity (nulliparous versus parous), and neighborhood of residence. Detailed OC histories were obtained during in-person interviews with subjects. In general the risk estimates were small, and not statistically significant. Compared to no use, having used OCs for 12 years or more was associated with a modest non-significant elevated breast cancer risk with an odds ratio (OR) of 1.4 (95% confidence interval (CI) = 0.8-2.4). Long-term (12 years or more) users of high-dose estrogen pills had a non-significant 60% higher breast cancer risk than never users (CI = 0.9-3.2). Early use was associated with slightly higher ORs among young women (age < or =35), and among parous women. Recent use was associated with somewhat higher ORs among parous women and women above age 36. Analyses by stage, body weight, and family history yielded similar results. This study is consistent with a modest effect of early OC use on breast cancer risk in young women. SN - 0167-6806 UR - https://www.unboundmedicine.com/medline/citation/9822222/Use_of_oral_contraceptives_and_risk_of_breast_cancer_in_young_women_ L2 - http://www.diseaseinfosearch.org/result/5395 DB - PRIME DP - Unbound Medicine ER -