Tags

Type your tag names separated by a space and hit enter

Effect of omeprazole 20 mg twice daily on duodenogastric and gastro-oesophageal bile reflux in Barrett's oesophagus.
Gut 1998; 43(5):603-6Gut

Abstract

BACKGROUND

Both acid and duodenal contents are thought to be responsible for the mucosal damage in Barrett's oesophagus, a condition often treated medically. However, little is known about the effect of omeprazole on duodenogastric reflux (DGR) and duodenogastro-oesophageal reflux (DGOR).

AIMS

To study the effect of omeprazole 20 mg twice daily on DGR and DGOR, using the technique of ambulatory bilirubin monitoring.

METHODS

Twenty three patients with Barrett's oesophagus underwent manometry followed by 24 hour oesophageal and gastric pH monitoring. In conjunction with pH monitoring, 11 patients (group 1) underwent oesophageal bilirubin monitoring and 12 patients (group 2) underwent gastric bilirubin monitoring, both before and during treatment with omeprazole 20 mg twice daily.

RESULTS

In both groups there was a significant reduction in oesophageal acid (pH<4) reflux (p<0.005) and a significant increase in the time gastric pH was above 4 (p<0.005). In group 1, median total oesophageal bilirubin exposure was significantly reduced from 28.9% to 2.4% (p<0.005). In group 2, median total gastric bilirubin exposure was significantly reduced from 24.9% to 7.2% (p<0.005).

CONCLUSIONS

Treatment of Barrett's oesophagus with omeprazole 20 mg twice daily results in a notable reduction in the exposure of the oesophagus to both acid and duodenal contents. In addition, delivery of duodenal contents to the upper gastric body is reduced.

Authors+Show Affiliations

Department of Surgery, Guy's Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

9824338

Citation

Marshall, R E., et al. "Effect of Omeprazole 20 Mg Twice Daily On Duodenogastric and Gastro-oesophageal Bile Reflux in Barrett's Oesophagus." Gut, vol. 43, no. 5, 1998, pp. 603-6.
Marshall RE, Anggiansah A, Manifold DK, et al. Effect of omeprazole 20 mg twice daily on duodenogastric and gastro-oesophageal bile reflux in Barrett's oesophagus. Gut. 1998;43(5):603-6.
Marshall, R. E., Anggiansah, A., Manifold, D. K., Owen, W. A., & Owen, W. J. (1998). Effect of omeprazole 20 mg twice daily on duodenogastric and gastro-oesophageal bile reflux in Barrett's oesophagus. Gut, 43(5), pp. 603-6.
Marshall RE, et al. Effect of Omeprazole 20 Mg Twice Daily On Duodenogastric and Gastro-oesophageal Bile Reflux in Barrett's Oesophagus. Gut. 1998;43(5):603-6. PubMed PMID: 9824338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of omeprazole 20 mg twice daily on duodenogastric and gastro-oesophageal bile reflux in Barrett's oesophagus. AU - Marshall,R E, AU - Anggiansah,A, AU - Manifold,D K, AU - Owen,W A, AU - Owen,W J, PY - 1998/11/21/pubmed PY - 1998/11/21/medline PY - 1998/11/21/entrez SP - 603 EP - 6 JF - Gut JO - Gut VL - 43 IS - 5 N2 - BACKGROUND: Both acid and duodenal contents are thought to be responsible for the mucosal damage in Barrett's oesophagus, a condition often treated medically. However, little is known about the effect of omeprazole on duodenogastric reflux (DGR) and duodenogastro-oesophageal reflux (DGOR). AIMS: To study the effect of omeprazole 20 mg twice daily on DGR and DGOR, using the technique of ambulatory bilirubin monitoring. METHODS: Twenty three patients with Barrett's oesophagus underwent manometry followed by 24 hour oesophageal and gastric pH monitoring. In conjunction with pH monitoring, 11 patients (group 1) underwent oesophageal bilirubin monitoring and 12 patients (group 2) underwent gastric bilirubin monitoring, both before and during treatment with omeprazole 20 mg twice daily. RESULTS: In both groups there was a significant reduction in oesophageal acid (pH<4) reflux (p<0.005) and a significant increase in the time gastric pH was above 4 (p<0.005). In group 1, median total oesophageal bilirubin exposure was significantly reduced from 28.9% to 2.4% (p<0.005). In group 2, median total gastric bilirubin exposure was significantly reduced from 24.9% to 7.2% (p<0.005). CONCLUSIONS: Treatment of Barrett's oesophagus with omeprazole 20 mg twice daily results in a notable reduction in the exposure of the oesophagus to both acid and duodenal contents. In addition, delivery of duodenal contents to the upper gastric body is reduced. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/9824338/Effect_of_omeprazole_20_mg_twice_daily_on_duodenogastric_and_gastro_oesophageal_bile_reflux_in_Barrett's_oesophagus_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=9824338 DB - PRIME DP - Unbound Medicine ER -