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Circadian antidiuretic hormone variation in elderly men complaining of persistent nocturia after urinary flow obstruction removal.
Scand J Urol Nephrol. 1998 Sep; 32(5):320-4.SJ

Abstract

Persistence of nocturia after prostatic resection in healthy patients without symptoms referred to residual bladder instability and to pathological polyuria seems to be caused by an increased urine production at night. The more accreditate mechanism involved is the relevant decreased ADH secretion pattern which occurs at night. In our study, patients with nocturnal poliuria showed significantly low plasmatic vasopressin levels compared with a control group. The aim of this study was to evaluate whether the persistence of nocturia after prostatic resection in healthy patients, without symptoms referred due to residual bladder instability and important polyuria, could be due to a decrease or a lack of increase in antidiuretic hormone (ADH) nocturnal levels following increased urine production at night. Serum ADH, atrial natriuretic peptide (ANP) and osmolality were assessed at 4-h intervals in 12 patients complaining of residual nocturia (group A) and in a control group of 13 patients who had undergone a complete resolution of nocturia after prostate ablation (group B). In the 25 patients involved in the study (mean age 65.8 years), no significant differences were observed in the two groups concerning mean age (67.5 years for group A, 64 years for group B). Mean nocturnal urine volume (1080 +/- 490 ml) in group A patients was significantly higher than in group B (500 +/- 100 ml) (p < 0.001), while no significant differences were found in diurnal diuresis. Mean plasma vasopressin levels of the 12 patients showing an increased nocturnal micturition were found to be significantly lower at all 4-h intervals when compared with the control group (p < 0.05). Individual fluctuations in serum osmolality were slight and insignificant within the normal range in all patients. The diurnal variation of plasma atrial natriuretic peptide was within the reference limits for all subjects during the 24-h period. Our results lead us to believe that residual nocturia after prostatic resection seems to be caused by an increased urine production at night due to a decreased ADH secretion pattern.

Authors+Show Affiliations

University of Torino, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9825393

Citation

Bodo, G, et al. "Circadian Antidiuretic Hormone Variation in Elderly Men Complaining of Persistent Nocturia After Urinary Flow Obstruction Removal." Scandinavian Journal of Urology and Nephrology, vol. 32, no. 5, 1998, pp. 320-4.
Bodo G, Gontero P, Casetta G, et al. Circadian antidiuretic hormone variation in elderly men complaining of persistent nocturia after urinary flow obstruction removal. Scand J Urol Nephrol. 1998;32(5):320-4.
Bodo, G., Gontero, P., Casetta, G., Alpa, M., Brossa, G., Russo, R., & Tizzani, A. (1998). Circadian antidiuretic hormone variation in elderly men complaining of persistent nocturia after urinary flow obstruction removal. Scandinavian Journal of Urology and Nephrology, 32(5), 320-4.
Bodo G, et al. Circadian Antidiuretic Hormone Variation in Elderly Men Complaining of Persistent Nocturia After Urinary Flow Obstruction Removal. Scand J Urol Nephrol. 1998;32(5):320-4. PubMed PMID: 9825393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian antidiuretic hormone variation in elderly men complaining of persistent nocturia after urinary flow obstruction removal. AU - Bodo,G, AU - Gontero,P, AU - Casetta,G, AU - Alpa,M, AU - Brossa,G, AU - Russo,R, AU - Tizzani,A, PY - 1998/11/24/pubmed PY - 1998/11/24/medline PY - 1998/11/24/entrez SP - 320 EP - 4 JF - Scandinavian journal of urology and nephrology JO - Scand J Urol Nephrol VL - 32 IS - 5 N2 - Persistence of nocturia after prostatic resection in healthy patients without symptoms referred to residual bladder instability and to pathological polyuria seems to be caused by an increased urine production at night. The more accreditate mechanism involved is the relevant decreased ADH secretion pattern which occurs at night. In our study, patients with nocturnal poliuria showed significantly low plasmatic vasopressin levels compared with a control group. The aim of this study was to evaluate whether the persistence of nocturia after prostatic resection in healthy patients, without symptoms referred due to residual bladder instability and important polyuria, could be due to a decrease or a lack of increase in antidiuretic hormone (ADH) nocturnal levels following increased urine production at night. Serum ADH, atrial natriuretic peptide (ANP) and osmolality were assessed at 4-h intervals in 12 patients complaining of residual nocturia (group A) and in a control group of 13 patients who had undergone a complete resolution of nocturia after prostate ablation (group B). In the 25 patients involved in the study (mean age 65.8 years), no significant differences were observed in the two groups concerning mean age (67.5 years for group A, 64 years for group B). Mean nocturnal urine volume (1080 +/- 490 ml) in group A patients was significantly higher than in group B (500 +/- 100 ml) (p < 0.001), while no significant differences were found in diurnal diuresis. Mean plasma vasopressin levels of the 12 patients showing an increased nocturnal micturition were found to be significantly lower at all 4-h intervals when compared with the control group (p < 0.05). Individual fluctuations in serum osmolality were slight and insignificant within the normal range in all patients. The diurnal variation of plasma atrial natriuretic peptide was within the reference limits for all subjects during the 24-h period. Our results lead us to believe that residual nocturia after prostatic resection seems to be caused by an increased urine production at night due to a decreased ADH secretion pattern. SN - 0036-5599 UR - https://www.unboundmedicine.com/medline/citation/9825393/Circadian_antidiuretic_hormone_variation_in_elderly_men_complaining_of_persistent_nocturia_after_urinary_flow_obstruction_removal_ L2 - https://www.tandfonline.com/doi/full/10.1080/003655998750015269 DB - PRIME DP - Unbound Medicine ER -