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Role of 4-1BB in immune responses.
Semin Immunol. 1998 Dec; 10(6):481-9.SI

Abstract

4-1BB is an inducible T cell surface receptor which belongs to the tumor necrosis factor receptor superfamily, a group of cysteine-rich cell-surface molecules. Both human and mouse 4-1BB recently received HLDA nomenclature. Naive T cells lack 4-1BB, which is not only induced upon T cell activation, but also remains on activated T cells. The natural ligand for 4-1BB, 4-1BBL is also induced and is found on activated antigen-presenting cells. Cross-linking of the 4-1BB molecule by agonistic antibody transmits a distinct and potent co-stimulatory signal leading to the activation and differentiation of CD4(+) and CD8(+) cells. 4-1BB transmits signals through the TRAF2-NIK pathway and activates NF-kappaB. Signals relayed through 4-1BB inhibit activation-induced cell death and rescue the immune system during the post-CD28 phase. Antibodies to the 4-1BB molecule can increase GVHD, accelerate the rejection of cardiac allograft and skin transplants, and eradicate established tumors. Interference with the 4-1BB-4-1BBL pathway may be of therapeutic use in the treatment of HIV infection. 4-1BB-deficient mice show dysregulated immune responses and mount elevated Ig responses to T-dependent antigens.

Authors+Show Affiliations

Indiana University School of Medicine, and the Walther Oncology Center, 635 Barnhill Drive, Indianapolis, IN, 46202-5120, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

9826581

Citation

Vinay, D S., and B S. Kwon. "Role of 4-1BB in Immune Responses." Seminars in Immunology, vol. 10, no. 6, 1998, pp. 481-9.
Vinay DS, Kwon BS. Role of 4-1BB in immune responses. Semin Immunol. 1998;10(6):481-9.
Vinay, D. S., & Kwon, B. S. (1998). Role of 4-1BB in immune responses. Seminars in Immunology, 10(6), 481-9.
Vinay DS, Kwon BS. Role of 4-1BB in Immune Responses. Semin Immunol. 1998;10(6):481-9. PubMed PMID: 9826581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of 4-1BB in immune responses. AU - Vinay,D S, AU - Kwon,B S, PY - 1998/11/25/pubmed PY - 1998/11/25/medline PY - 1998/11/25/entrez SP - 481 EP - 9 JF - Seminars in immunology JO - Semin Immunol VL - 10 IS - 6 N2 - 4-1BB is an inducible T cell surface receptor which belongs to the tumor necrosis factor receptor superfamily, a group of cysteine-rich cell-surface molecules. Both human and mouse 4-1BB recently received HLDA nomenclature. Naive T cells lack 4-1BB, which is not only induced upon T cell activation, but also remains on activated T cells. The natural ligand for 4-1BB, 4-1BBL is also induced and is found on activated antigen-presenting cells. Cross-linking of the 4-1BB molecule by agonistic antibody transmits a distinct and potent co-stimulatory signal leading to the activation and differentiation of CD4(+) and CD8(+) cells. 4-1BB transmits signals through the TRAF2-NIK pathway and activates NF-kappaB. Signals relayed through 4-1BB inhibit activation-induced cell death and rescue the immune system during the post-CD28 phase. Antibodies to the 4-1BB molecule can increase GVHD, accelerate the rejection of cardiac allograft and skin transplants, and eradicate established tumors. Interference with the 4-1BB-4-1BBL pathway may be of therapeutic use in the treatment of HIV infection. 4-1BB-deficient mice show dysregulated immune responses and mount elevated Ig responses to T-dependent antigens. SN - 1044-5323 UR - https://www.unboundmedicine.com/medline/citation/9826581/Role_of_4_1BB_in_immune_responses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1044-5323(98)90157-9 DB - PRIME DP - Unbound Medicine ER -