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Physical activity and benign prostatic hyperplasia.
Arch Intern Med 1998; 158(21):2349-56AI

Abstract

BACKGROUND

Benign prostatic hyperplasia (BPH) leading to prostatic enlargement and lower urinary tract symptoms is highly prevalent among older men. Sympathetic nervous system activity, which is decreased by physical activity, is associated with increased prostatic smooth-muscle tone and prostatic symptoms. Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study.

METHODS

We observed men who were aged 40 to 75 years at baseline in 1986 for subsequent incidence of surgery for BPH. The men were free of diagnosed cancer, including prostate cancer at baseline and during follow-up, had not had a radical prostatectomy, and provided data on physical activity. Cases were men who under-went BPH surgery between 1986 and 1994 (n = 1890) or, among those who did not have surgery, who scored 15 or more points of 35 (n = 1853) on 7 questions about lower urinary tract symptoms modified from the American Urological Association Symptom Index. Noncases were men who scored 7 points or less (n = 21745). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from multiple logistic regression models.

RESULTS

After controlling for age, race or ethnicity, alcohol consumption, and smoking, physical activity was inversely related with total BPH (extreme quintiles: OR, 0.75; 95% CI, 0.67-0.85; P for trend, <.001), surgery for BPH (OR, 0.76; 95% CI, 0.64-0.90; P for trend, <.001), and symptomatic BPH (OR, 0.75; 95% CI, 0.64-0.87; P for trend, <.001). Walking, the most prevalent activity, was inversely related to BPH risk; men who walked 2 to 3 h/wk had a 25% lower risk of total BPH.

CONCLUSION

Our results indicate that more physically active men have a lower frequency of lower urinary tract symptoms.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA. elizabeth.platz@channing.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9827786

Citation

Platz, E A., et al. "Physical Activity and Benign Prostatic Hyperplasia." Archives of Internal Medicine, vol. 158, no. 21, 1998, pp. 2349-56.
Platz EA, Kawachi I, Rimm EB, et al. Physical activity and benign prostatic hyperplasia. Arch Intern Med. 1998;158(21):2349-56.
Platz, E. A., Kawachi, I., Rimm, E. B., Colditz, G. A., Stampfer, M. J., Willett, W. C., & Giovannucci, E. (1998). Physical activity and benign prostatic hyperplasia. Archives of Internal Medicine, 158(21), pp. 2349-56.
Platz EA, et al. Physical Activity and Benign Prostatic Hyperplasia. Arch Intern Med. 1998 Nov 23;158(21):2349-56. PubMed PMID: 9827786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity and benign prostatic hyperplasia. AU - Platz,E A, AU - Kawachi,I, AU - Rimm,E B, AU - Colditz,G A, AU - Stampfer,M J, AU - Willett,W C, AU - Giovannucci,E, PY - 1998/11/25/pubmed PY - 1998/11/25/medline PY - 1998/11/25/entrez SP - 2349 EP - 56 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 158 IS - 21 N2 - BACKGROUND: Benign prostatic hyperplasia (BPH) leading to prostatic enlargement and lower urinary tract symptoms is highly prevalent among older men. Sympathetic nervous system activity, which is decreased by physical activity, is associated with increased prostatic smooth-muscle tone and prostatic symptoms. Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study. METHODS: We observed men who were aged 40 to 75 years at baseline in 1986 for subsequent incidence of surgery for BPH. The men were free of diagnosed cancer, including prostate cancer at baseline and during follow-up, had not had a radical prostatectomy, and provided data on physical activity. Cases were men who under-went BPH surgery between 1986 and 1994 (n = 1890) or, among those who did not have surgery, who scored 15 or more points of 35 (n = 1853) on 7 questions about lower urinary tract symptoms modified from the American Urological Association Symptom Index. Noncases were men who scored 7 points or less (n = 21745). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from multiple logistic regression models. RESULTS: After controlling for age, race or ethnicity, alcohol consumption, and smoking, physical activity was inversely related with total BPH (extreme quintiles: OR, 0.75; 95% CI, 0.67-0.85; P for trend, <.001), surgery for BPH (OR, 0.76; 95% CI, 0.64-0.90; P for trend, <.001), and symptomatic BPH (OR, 0.75; 95% CI, 0.64-0.87; P for trend, <.001). Walking, the most prevalent activity, was inversely related to BPH risk; men who walked 2 to 3 h/wk had a 25% lower risk of total BPH. CONCLUSION: Our results indicate that more physically active men have a lower frequency of lower urinary tract symptoms. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/9827786/Physical_activity_and_benign_prostatic_hyperplasia_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/158/pg/2349 DB - PRIME DP - Unbound Medicine ER -