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Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men.
Br J Nutr. 1998 Aug; 80(2):163-7.BJ

Abstract

The effect of partial dietary replacement of linoleic acid (18:2n-6; linoleic acid-rich diet) with alpha-linolenic acid (18:3n-3; alpha-linolenic acid-rich diet) on plasma lipids was investigated in twenty-nine healthy young men. After a 2-week stabilization period subjects were randomly assigned to either the alpha-linolenic acid-rich diet group (n 15), receiving a mean of 10.1 g of alpha-linolenic acid and 12.1 g of linoleic acid/d, or the linoleic acid-rich diet group (n 14), receiving a mean of 1.0 g of alpha-linolenic acid and 21.0 g of linoleic acid/d, for a 6-week test period. Blood samples were taken at the commencement of the stabilization period and at the start (week 0), midpoint (week 3) and endpoint (week 6) of the test period and plasma lipids analysed. The changes occurring on the linoleic acid-rich diet and alpha-linolenic acid-rich diet were compared but no significant differences in the changes in plasma total cholesterol, LDL-cholesterol, HDL-cholesterol, the subfractions HDL2 and HDL3 or triacylglycerols were found. These results indicate that dietary replacement of linoleic acid with alpha-linolenic acid in the diet of healthy male subjects offers similar cardioprotective benefits with respect to lipid metabolism.

Authors+Show Affiliations

Department of Biochemistry, University of Sydney, NSW, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9828757

Citation

Pang, D, et al. "Replacement of Linoleic Acid With Alpha-linolenic Acid Does Not Alter Blood Lipids in Normolipidaemic Men." The British Journal of Nutrition, vol. 80, no. 2, 1998, pp. 163-7.
Pang D, Allman-Farinelli MA, Wong T, et al. Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. Br J Nutr. 1998;80(2):163-7.
Pang, D., Allman-Farinelli, M. A., Wong, T., Barnes, R., & Kingham, K. M. (1998). Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. The British Journal of Nutrition, 80(2), 163-7.
Pang D, et al. Replacement of Linoleic Acid With Alpha-linolenic Acid Does Not Alter Blood Lipids in Normolipidaemic Men. Br J Nutr. 1998;80(2):163-7. PubMed PMID: 9828757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Replacement of linoleic acid with alpha-linolenic acid does not alter blood lipids in normolipidaemic men. AU - Pang,D, AU - Allman-Farinelli,M A, AU - Wong,T, AU - Barnes,R, AU - Kingham,K M, PY - 1998/11/26/pubmed PY - 1998/11/26/medline PY - 1998/11/26/entrez SP - 163 EP - 7 JF - The British journal of nutrition JO - Br J Nutr VL - 80 IS - 2 N2 - The effect of partial dietary replacement of linoleic acid (18:2n-6; linoleic acid-rich diet) with alpha-linolenic acid (18:3n-3; alpha-linolenic acid-rich diet) on plasma lipids was investigated in twenty-nine healthy young men. After a 2-week stabilization period subjects were randomly assigned to either the alpha-linolenic acid-rich diet group (n 15), receiving a mean of 10.1 g of alpha-linolenic acid and 12.1 g of linoleic acid/d, or the linoleic acid-rich diet group (n 14), receiving a mean of 1.0 g of alpha-linolenic acid and 21.0 g of linoleic acid/d, for a 6-week test period. Blood samples were taken at the commencement of the stabilization period and at the start (week 0), midpoint (week 3) and endpoint (week 6) of the test period and plasma lipids analysed. The changes occurring on the linoleic acid-rich diet and alpha-linolenic acid-rich diet were compared but no significant differences in the changes in plasma total cholesterol, LDL-cholesterol, HDL-cholesterol, the subfractions HDL2 and HDL3 or triacylglycerols were found. These results indicate that dietary replacement of linoleic acid with alpha-linolenic acid in the diet of healthy male subjects offers similar cardioprotective benefits with respect to lipid metabolism. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/9828757/Replacement_of_linoleic_acid_with_alpha_linolenic_acid_does_not_alter_blood_lipids_in_normolipidaemic_men_ L2 - https://www.cambridge.org/core/product/identifier/S0007114598001068/type/journal_article DB - PRIME DP - Unbound Medicine ER -