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Diagnostic value of serological markers for celiac disease in diabetic children and adolescents.
J Pediatr Endocrinol Metab 1998 Nov-Dec; 11(6):751-6JP

Abstract

OBJECTIVE

To determine the accuracy of antigliadin and antiendomysium antibodies for the diagnosis of celiac disease in diabetic children and adolescents with and without digestive symptoms.

STUDY DESIGN

177 children and adolescents with IDDM aged 15.4 +/- 5.4 years (mean +/- SD). Antigliadin (ELISA) and antiendomysium (IFI) antibodies were measured in 177 and 35 patients, respectively.

RESULTS

Seven of 177 patients (3.9%; 95% confidence interval: 1.1-6.7) had celiac disease. The specificities of antiendomysium antibodies test (83%), IgA-antigliadin antibodies test (80%) and IgG-antigliadin antibodies test (90%) and the positive predictive values of these antibodies (55-75%) were lower than those obtained with the combined determination of these antibodies (100%). Negative antibodies and normal mucosa in one determination did not rule out the development of celiac disease later.

CONCLUSIONS

The combined determination of antigliadin and antiendomysium antibodies is the test of choice in screening for celiac disease in diabetic patients. The yearly investigation of these antibodies is a reliable method for detecting silent celiac disease in this population.

Authors+Show Affiliations

Department of Pediatrics, Ramón y Cajal Hospital, Alcalá de Henares University School of Medicine, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9829231

Citation

Roldan, M B., et al. "Diagnostic Value of Serological Markers for Celiac Disease in Diabetic Children and Adolescents." Journal of Pediatric Endocrinology & Metabolism : JPEM, vol. 11, no. 6, 1998, pp. 751-6.
Roldan MB, Barrio R, Roy G, et al. Diagnostic value of serological markers for celiac disease in diabetic children and adolescents. J Pediatr Endocrinol Metab. 1998;11(6):751-6.
Roldan, M. B., Barrio, R., Roy, G., Parra, C., Alonso, M., Yturriaga, R., & Camarero, C. (1998). Diagnostic value of serological markers for celiac disease in diabetic children and adolescents. Journal of Pediatric Endocrinology & Metabolism : JPEM, 11(6), pp. 751-6.
Roldan MB, et al. Diagnostic Value of Serological Markers for Celiac Disease in Diabetic Children and Adolescents. J Pediatr Endocrinol Metab. 1998;11(6):751-6. PubMed PMID: 9829231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of serological markers for celiac disease in diabetic children and adolescents. AU - Roldan,M B, AU - Barrio,R, AU - Roy,G, AU - Parra,C, AU - Alonso,M, AU - Yturriaga,R, AU - Camarero,C, PY - 1998/11/26/pubmed PY - 1998/11/26/medline PY - 1998/11/26/entrez SP - 751 EP - 6 JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J. Pediatr. Endocrinol. Metab. VL - 11 IS - 6 N2 - OBJECTIVE: To determine the accuracy of antigliadin and antiendomysium antibodies for the diagnosis of celiac disease in diabetic children and adolescents with and without digestive symptoms. STUDY DESIGN: 177 children and adolescents with IDDM aged 15.4 +/- 5.4 years (mean +/- SD). Antigliadin (ELISA) and antiendomysium (IFI) antibodies were measured in 177 and 35 patients, respectively. RESULTS: Seven of 177 patients (3.9%; 95% confidence interval: 1.1-6.7) had celiac disease. The specificities of antiendomysium antibodies test (83%), IgA-antigliadin antibodies test (80%) and IgG-antigliadin antibodies test (90%) and the positive predictive values of these antibodies (55-75%) were lower than those obtained with the combined determination of these antibodies (100%). Negative antibodies and normal mucosa in one determination did not rule out the development of celiac disease later. CONCLUSIONS: The combined determination of antigliadin and antiendomysium antibodies is the test of choice in screening for celiac disease in diabetic patients. The yearly investigation of these antibodies is a reliable method for detecting silent celiac disease in this population. SN - 0334-018X UR - https://www.unboundmedicine.com/medline/citation/9829231/Diagnostic_value_of_serological_markers_for_celiac_disease_in_diabetic_children_and_adolescents_ L2 - https://www.degruyter.com/doi/10.1515/jpem.1998.11.6.751 DB - PRIME DP - Unbound Medicine ER -