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[Influence of risk factors and pharmacological treatment on mortality in patients with essential hypertension].
Rev Med Chil 1998; 126(7):745-52RM

Abstract

BACKGROUND

The V JNC consensus stated that although new antihypertensive agents, such as angiotensin converting enzyme inhibitors and calcium channel blockers, are considered safer drugs, there is no firm evidence from large controlled trials that these drugs are associated with a lower cardiovascular mortality.

AIM

To study the association between cardiovascular risk factors, blood pressure levels, pharmacological treatment and mortality in a group of hypertensive patients followed at an hypertension outpatient clinic.

PATIENTS AND METHODS

Patients with essential hypertension were treated with different antihypertensive medications, according to physicians criteria, and controlled until death or loss from follow up. Causes of death were obtained from hospital records and death certificates. Survival was analyzed using life tables, comparisons between groups of patients were done using chi square or a Cox's proportional hazards model.

RESULTS

Three hundred thirty-nine hypertensive patients aged 33 to 80 years old were followed for a mean period of 9.8 +/- 4.9 years. Eighty-six were treated with beta blockers, 64 with diuretics, 133 with calcium antagonists and 56 with ACE inhibitors. Blood pressure dropped similarly with all medications. During follow up, 79 patients died. Life table analysis showed that patients with a history of angina, diabetes or myocardial infarction had higher mortality rates. Similarly, patients treated with beta blockers and diuretics had higher mortality than patients treated with calcium antagonists or angiotensin converting enzyme inhibitors. The proportional hazards model showed that the effect of treatment modality persisted after correction for the other risk factors for mortality.

CONCLUSIONS

In this series of hypertensive patients, those treated with beta blockers or diuretics had higher mortality rates than those receiving calcium channel antagonists or angiotensin converting enzyme inhibitors.

Authors+Show Affiliations

Departamento de Medicina, Facultad de Medicina, Universidad de Chile, Santiago, Chile.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

9830766

Citation

Román, O, et al. "[Influence of Risk Factors and Pharmacological Treatment On Mortality in Patients With Essential Hypertension]." Revista Medica De Chile, vol. 126, no. 7, 1998, pp. 745-52.
Román O, Cuevas G, Bunout D. [Influence of risk factors and pharmacological treatment on mortality in patients with essential hypertension]. Rev Med Chil. 1998;126(7):745-52.
Román, O., Cuevas, G., & Bunout, D. (1998). [Influence of risk factors and pharmacological treatment on mortality in patients with essential hypertension]. Revista Medica De Chile, 126(7), pp. 745-52.
Román O, Cuevas G, Bunout D. [Influence of Risk Factors and Pharmacological Treatment On Mortality in Patients With Essential Hypertension]. Rev Med Chil. 1998;126(7):745-52. PubMed PMID: 9830766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Influence of risk factors and pharmacological treatment on mortality in patients with essential hypertension]. AU - Román,O, AU - Cuevas,G, AU - Bunout,D, PY - 1998/11/27/pubmed PY - 1998/11/27/medline PY - 1998/11/27/entrez SP - 745 EP - 52 JF - Revista medica de Chile JO - Rev Med Chil VL - 126 IS - 7 N2 - BACKGROUND: The V JNC consensus stated that although new antihypertensive agents, such as angiotensin converting enzyme inhibitors and calcium channel blockers, are considered safer drugs, there is no firm evidence from large controlled trials that these drugs are associated with a lower cardiovascular mortality. AIM: To study the association between cardiovascular risk factors, blood pressure levels, pharmacological treatment and mortality in a group of hypertensive patients followed at an hypertension outpatient clinic. PATIENTS AND METHODS: Patients with essential hypertension were treated with different antihypertensive medications, according to physicians criteria, and controlled until death or loss from follow up. Causes of death were obtained from hospital records and death certificates. Survival was analyzed using life tables, comparisons between groups of patients were done using chi square or a Cox's proportional hazards model. RESULTS: Three hundred thirty-nine hypertensive patients aged 33 to 80 years old were followed for a mean period of 9.8 +/- 4.9 years. Eighty-six were treated with beta blockers, 64 with diuretics, 133 with calcium antagonists and 56 with ACE inhibitors. Blood pressure dropped similarly with all medications. During follow up, 79 patients died. Life table analysis showed that patients with a history of angina, diabetes or myocardial infarction had higher mortality rates. Similarly, patients treated with beta blockers and diuretics had higher mortality than patients treated with calcium antagonists or angiotensin converting enzyme inhibitors. The proportional hazards model showed that the effect of treatment modality persisted after correction for the other risk factors for mortality. CONCLUSIONS: In this series of hypertensive patients, those treated with beta blockers or diuretics had higher mortality rates than those receiving calcium channel antagonists or angiotensin converting enzyme inhibitors. SN - 0034-9887 UR - https://www.unboundmedicine.com/medline/citation/9830766/[Influence_of_risk_factors_and_pharmacological_treatment_on_mortality_in_patients_with_essential_hypertension]_ L2 - http://www.diseaseinfosearch.org/result/8360 DB - PRIME DP - Unbound Medicine ER -