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Pigeon fanciers' lung: the mucin antigen is present in pigeon droppings and pigeon bloom.
Int Arch Allergy Immunol. 1998 Nov; 117(3):187-93.IA

Abstract

BACKGROUND

Pigeon intestinal mucin has been implicated as an important antigen pigeon fanciers' lung. This study investigated whether mucin is detectable in pigeon droppings and bloom, the likely antigenic sources in disease.

METHODS

Soluble extracts of a number of materials found in a pigeon loft were prepared and specific IgG subclass antibodies to these antigens were measured in 14 antibody-positive pigeon fanciers. Cross-reactivity between these materials and purified pigeon intestinal mucin was investigated by inhibition of anti-mucin ELISA. Mucin was purified from the soluble extracts of these crude antigen mixtures by CsCl density gradient centrifugation.

RESULTS

The patterns of IgG subclass responses to purified pigeon intestinal mucin and to the four materials collected from the pigeon loft were similar. Subclass differences between symptomatic and asymptomatic individuals, demonstrable against purified mucin, were similarly seen against pigeon droppings and pigeon bloom. Both pigeon droppings and pigeon bloom were capable of inhibiting IgG binding to purified pigeon mucin, and mucin inhibited substantially the binding of IgG to these materials. Glycoprotein with a density similar to that described for pigeon intestinal mucin was purified from each source.

CONCLUSION

Pigeon intestinal mucin is present in a variety of materials found in the environment of the pigeon loft in a form capable of reacting with anti-mucin antibodies in the sera of exposed individuals. Reduction in exposure to these materials may decrease the likelihood of developing pigeon fanciers' lung and minimise reactions in sensitised individuals.

Authors+Show Affiliations

Department of Immunology, The Medical School, University of Newcastle upon Tyne Carlisle, UK. C.I.Baldwin@newcastle.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9831806

Citation

Baldwin, C I., et al. "Pigeon Fanciers' Lung: the Mucin Antigen Is Present in Pigeon Droppings and Pigeon Bloom." International Archives of Allergy and Immunology, vol. 117, no. 3, 1998, pp. 187-93.
Baldwin CI, Stevens B, Connors S, et al. Pigeon fanciers' lung: the mucin antigen is present in pigeon droppings and pigeon bloom. Int Arch Allergy Immunol. 1998;117(3):187-93.
Baldwin, C. I., Stevens, B., Connors, S., Todd, A., Bourke, S. J., Calvert, J. E., & Allen, A. (1998). Pigeon fanciers' lung: the mucin antigen is present in pigeon droppings and pigeon bloom. International Archives of Allergy and Immunology, 117(3), 187-93.
Baldwin CI, et al. Pigeon Fanciers' Lung: the Mucin Antigen Is Present in Pigeon Droppings and Pigeon Bloom. Int Arch Allergy Immunol. 1998;117(3):187-93. PubMed PMID: 9831806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pigeon fanciers' lung: the mucin antigen is present in pigeon droppings and pigeon bloom. AU - Baldwin,C I, AU - Stevens,B, AU - Connors,S, AU - Todd,A, AU - Bourke,S J, AU - Calvert,J E, AU - Allen,A, PY - 1998/12/1/pubmed PY - 2000/8/16/medline PY - 1998/12/1/entrez SP - 187 EP - 93 JF - International archives of allergy and immunology JO - Int Arch Allergy Immunol VL - 117 IS - 3 N2 - BACKGROUND: Pigeon intestinal mucin has been implicated as an important antigen pigeon fanciers' lung. This study investigated whether mucin is detectable in pigeon droppings and bloom, the likely antigenic sources in disease. METHODS: Soluble extracts of a number of materials found in a pigeon loft were prepared and specific IgG subclass antibodies to these antigens were measured in 14 antibody-positive pigeon fanciers. Cross-reactivity between these materials and purified pigeon intestinal mucin was investigated by inhibition of anti-mucin ELISA. Mucin was purified from the soluble extracts of these crude antigen mixtures by CsCl density gradient centrifugation. RESULTS: The patterns of IgG subclass responses to purified pigeon intestinal mucin and to the four materials collected from the pigeon loft were similar. Subclass differences between symptomatic and asymptomatic individuals, demonstrable against purified mucin, were similarly seen against pigeon droppings and pigeon bloom. Both pigeon droppings and pigeon bloom were capable of inhibiting IgG binding to purified pigeon mucin, and mucin inhibited substantially the binding of IgG to these materials. Glycoprotein with a density similar to that described for pigeon intestinal mucin was purified from each source. CONCLUSION: Pigeon intestinal mucin is present in a variety of materials found in the environment of the pigeon loft in a form capable of reacting with anti-mucin antibodies in the sera of exposed individuals. Reduction in exposure to these materials may decrease the likelihood of developing pigeon fanciers' lung and minimise reactions in sensitised individuals. SN - 1018-2438 UR - https://www.unboundmedicine.com/medline/citation/9831806/Pigeon_fanciers'_lung:_the_mucin_antigen_is_present_in_pigeon_droppings_and_pigeon_bloom_ L2 - https://www.karger.com?DOI=10.1159/000024009 DB - PRIME DP - Unbound Medicine ER -