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Attenuation of the discriminative stimulus effects of ethanol by the benzodiazepine partial inverse agonist Ro 15-4513.
Behav Pharmacol. 1997 Jun; 8(2-3):139-46.BP

Abstract

The aim of the present study was to investigate whether ethanol training affects the ability of Ro 15-4513 to block the discriminative stimulus effects of ethanol dose differentially. Three different groups of rats were trained to discriminate 1.0 g/kg ethanol (n = 8), 1.5 g/kg ethanol (n = 7) or 2.0 g/kg ethanol (n = 8) from water in a two-lever, food-reinforced procedure. Ethanol and water were administered by gavage 20 min before the onset of the session. When the discrimination performance was stable, rats were pretreated with Ro 15-4513 (1-17 mg/kg; i.p.) 5 min before the administration of ethanol. Ro 15-4513 attenuated the discriminative stimulus effects of 1.0 and 1.5 g/kg ethanol but not 2.0 g/kg ethanol in each of the ethanol training groups. Overall, blockade of the discriminative stimulus effects of 1.0 and 1.5 g/kg ethanol by 5.6 mg/kg Ro 15-4513 occurred without significantly altering response rates or blood ethanol concentrations. A decrease in blood ethanol concentration was, however, found with 17 mg/kg Ro 15-4513 in combination with 2.0 g/kg ethanol. These results suggest that the benzodiazepine partial inverse agonist, Ro 15-4513, can attenuate the discriminative stimulus effects associated with low to moderate doses of ethanol (1.0-1.5 g/kg).

Authors+Show Affiliations

Department of Physiology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1083, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9833009

Citation

Gatto, G J., and K A. Grant. "Attenuation of the Discriminative Stimulus Effects of Ethanol By the Benzodiazepine Partial Inverse Agonist Ro 15-4513." Behavioural Pharmacology, vol. 8, no. 2-3, 1997, pp. 139-46.
Gatto GJ, Grant KA. Attenuation of the discriminative stimulus effects of ethanol by the benzodiazepine partial inverse agonist Ro 15-4513. Behav Pharmacol. 1997;8(2-3):139-46.
Gatto, G. J., & Grant, K. A. (1997). Attenuation of the discriminative stimulus effects of ethanol by the benzodiazepine partial inverse agonist Ro 15-4513. Behavioural Pharmacology, 8(2-3), 139-46.
Gatto GJ, Grant KA. Attenuation of the Discriminative Stimulus Effects of Ethanol By the Benzodiazepine Partial Inverse Agonist Ro 15-4513. Behav Pharmacol. 1997;8(2-3):139-46. PubMed PMID: 9833009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of the discriminative stimulus effects of ethanol by the benzodiazepine partial inverse agonist Ro 15-4513. AU - Gatto,G J, AU - Grant,K A, PY - 1997/6/1/pubmed PY - 1998/12/2/medline PY - 1997/6/1/entrez SP - 139 EP - 46 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 8 IS - 2-3 N2 - The aim of the present study was to investigate whether ethanol training affects the ability of Ro 15-4513 to block the discriminative stimulus effects of ethanol dose differentially. Three different groups of rats were trained to discriminate 1.0 g/kg ethanol (n = 8), 1.5 g/kg ethanol (n = 7) or 2.0 g/kg ethanol (n = 8) from water in a two-lever, food-reinforced procedure. Ethanol and water were administered by gavage 20 min before the onset of the session. When the discrimination performance was stable, rats were pretreated with Ro 15-4513 (1-17 mg/kg; i.p.) 5 min before the administration of ethanol. Ro 15-4513 attenuated the discriminative stimulus effects of 1.0 and 1.5 g/kg ethanol but not 2.0 g/kg ethanol in each of the ethanol training groups. Overall, blockade of the discriminative stimulus effects of 1.0 and 1.5 g/kg ethanol by 5.6 mg/kg Ro 15-4513 occurred without significantly altering response rates or blood ethanol concentrations. A decrease in blood ethanol concentration was, however, found with 17 mg/kg Ro 15-4513 in combination with 2.0 g/kg ethanol. These results suggest that the benzodiazepine partial inverse agonist, Ro 15-4513, can attenuate the discriminative stimulus effects associated with low to moderate doses of ethanol (1.0-1.5 g/kg). SN - 0955-8810 UR - https://www.unboundmedicine.com/medline/citation/9833009/Attenuation_of_the_discriminative_stimulus_effects_of_ethanol_by_the_benzodiazepine_partial_inverse_agonist_Ro_15_4513_ DB - PRIME DP - Unbound Medicine ER -