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Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo.
Acta Derm Venereol. 1998 Nov; 78(6):428-32.AD

Abstract

For the purpose of discovering natural products which possess hair growing activity, we examined about 1000 kinds of plant extracts concerning growth-promoting activity with respect to hair follicle cells. After an extensive search, we discovered that proanthocyanidins extracted from grape seeds promote proliferation of hair follicle cells isolated from mice by about 230% relative to controls (100%); and that proanthocyanidins possess remarkable hair-cycle-converting activity from the telogen phase to the anagen phase in C3H mice in vivo test systems. The profile of the active fraction of the proanthocyanidins was elucidated by thiolytic degradation and tannase hydrolysis. We found that the constitutive monomers were epicatechin and catechin; and that the degree of polymerization was 3.5. We demonstrated the possibility of using the proanthocyanidins extracted from grape seeds as agents inducing hair growth.

Authors+Show Affiliations

Tsukuba Research Laboratories, Kyowa Hakko Kogyo Co., Ibaraki, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9833041

Citation

Takahashi, T, et al. "Proanthocyanidins From Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells in Vitro and Convert Hair Cycle in Vivo." Acta Dermato-venereologica, vol. 78, no. 6, 1998, pp. 428-32.
Takahashi T, Kamiya T, Yokoo Y. Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. Acta Derm Venereol. 1998;78(6):428-32.
Takahashi, T., Kamiya, T., & Yokoo, Y. (1998). Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. Acta Dermato-venereologica, 78(6), 428-32.
Takahashi T, Kamiya T, Yokoo Y. Proanthocyanidins From Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells in Vitro and Convert Hair Cycle in Vivo. Acta Derm Venereol. 1998;78(6):428-32. PubMed PMID: 9833041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. AU - Takahashi,T, AU - Kamiya,T, AU - Yokoo,Y, PY - 1998/12/2/pubmed PY - 1998/12/2/medline PY - 1998/12/2/entrez SP - 428 EP - 32 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 78 IS - 6 N2 - For the purpose of discovering natural products which possess hair growing activity, we examined about 1000 kinds of plant extracts concerning growth-promoting activity with respect to hair follicle cells. After an extensive search, we discovered that proanthocyanidins extracted from grape seeds promote proliferation of hair follicle cells isolated from mice by about 230% relative to controls (100%); and that proanthocyanidins possess remarkable hair-cycle-converting activity from the telogen phase to the anagen phase in C3H mice in vivo test systems. The profile of the active fraction of the proanthocyanidins was elucidated by thiolytic degradation and tannase hydrolysis. We found that the constitutive monomers were epicatechin and catechin; and that the degree of polymerization was 3.5. We demonstrated the possibility of using the proanthocyanidins extracted from grape seeds as agents inducing hair growth. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/9833041/Proanthocyanidins_from_grape_seeds_promote_proliferation_of_mouse_hair_follicle_cells_in_vitro_and_convert_hair_cycle_in_vivo_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.1080/000155598442719 DB - PRIME DP - Unbound Medicine ER -