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The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes.
Neuropharmacology. 1998 Aug; 37(8):1019-32.N

Abstract

This study examined the effects of the H1-antagonist chlorpheniramine and the H2-antagonist ranitidine on reinforcement and anxiety-parameters following unilateral injection into the vicinity of the nucleus basalis magnocellularis (NBM). In Experiment 1, rats with chronically implanted cannulae were injected with chlorpheniramine or ranitidine (each at doses of 0.1, 1, 10 and 20 microg) and were placed into one of four restricted quadrants of a circular open field (closed corral) for a single conditioning trial. During the test for conditioned corral preference, when provided a choice between the four quadrants, only those rats injected with 10 or 20 microg chlorpheniramine spent more time in the treatment corral, indicative of a positively reinforcing action. None of the other doses of chlorpheniramine or of the H2-antagonist influenced rats' preference behavior. In Experiment 2, the elevated plus-maze (EPM) was used to gauge possible anxiolytic or anxiogenic effects of intra-basalis injection of chlorpheniramine or ranitidine (each at doses of 0.1, 1, 10 and 20 microg). A single injection of chlorpheniramine at 0.1 or 20 microg as well as ranitidine at 20 microg was found to exert anxiolytic-like effects in the EPM. Both compounds elevated the time spent on the open arms and increased scanning over the edge of an open arm. None of the other doses of the H1- and H2-antagonist influenced rats' behavior in the EPM. In sum, these findings show that H1- and H2-receptor antagonists differentially modulate reinforcement and fear-related processes in the NBM and thus, provide the first evidence for a behavioral relevance for the histaminergic innervation of this brain site.

Authors+Show Affiliations

Institute of Physiological Psychology I and Center for Biological and Medical Research, University of Düsseldorf, Germany. privou@uni-duesseldorf.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9833631

Citation

Privou, C, et al. "The H1- and H2-histamine Blockers Chlorpheniramine and Ranitidine Applied to the Nucleus Basalis Magnocellularis Region Modulate Anxiety and Reinforcement Related Processes." Neuropharmacology, vol. 37, no. 8, 1998, pp. 1019-32.
Privou C, Knoche A, Hasenöhrl RU, et al. The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes. Neuropharmacology. 1998;37(8):1019-32.
Privou, C., Knoche, A., Hasenöhrl, R. U., & Huston, J. P. (1998). The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes. Neuropharmacology, 37(8), 1019-32.
Privou C, et al. The H1- and H2-histamine Blockers Chlorpheniramine and Ranitidine Applied to the Nucleus Basalis Magnocellularis Region Modulate Anxiety and Reinforcement Related Processes. Neuropharmacology. 1998;37(8):1019-32. PubMed PMID: 9833631.
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TY - JOUR T1 - The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes. AU - Privou,C, AU - Knoche,A, AU - Hasenöhrl,R U, AU - Huston,J P, PY - 1998/12/2/pubmed PY - 1998/12/2/medline PY - 1998/12/2/entrez SP - 1019 EP - 32 JF - Neuropharmacology JO - Neuropharmacology VL - 37 IS - 8 N2 - This study examined the effects of the H1-antagonist chlorpheniramine and the H2-antagonist ranitidine on reinforcement and anxiety-parameters following unilateral injection into the vicinity of the nucleus basalis magnocellularis (NBM). In Experiment 1, rats with chronically implanted cannulae were injected with chlorpheniramine or ranitidine (each at doses of 0.1, 1, 10 and 20 microg) and were placed into one of four restricted quadrants of a circular open field (closed corral) for a single conditioning trial. During the test for conditioned corral preference, when provided a choice between the four quadrants, only those rats injected with 10 or 20 microg chlorpheniramine spent more time in the treatment corral, indicative of a positively reinforcing action. None of the other doses of chlorpheniramine or of the H2-antagonist influenced rats' preference behavior. In Experiment 2, the elevated plus-maze (EPM) was used to gauge possible anxiolytic or anxiogenic effects of intra-basalis injection of chlorpheniramine or ranitidine (each at doses of 0.1, 1, 10 and 20 microg). A single injection of chlorpheniramine at 0.1 or 20 microg as well as ranitidine at 20 microg was found to exert anxiolytic-like effects in the EPM. Both compounds elevated the time spent on the open arms and increased scanning over the edge of an open arm. None of the other doses of the H1- and H2-antagonist influenced rats' behavior in the EPM. In sum, these findings show that H1- and H2-receptor antagonists differentially modulate reinforcement and fear-related processes in the NBM and thus, provide the first evidence for a behavioral relevance for the histaminergic innervation of this brain site. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/9833631/The_H1__and_H2_histamine_blockers_chlorpheniramine_and_ranitidine_applied_to_the_nucleus_basalis_magnocellularis_region_modulate_anxiety_and_reinforcement_related_processes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028390898000872 DB - PRIME DP - Unbound Medicine ER -