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Tissue transglutaminase antibodies for coeliac disease screening.
Ital J Gastroenterol Hepatol 1998; 30(5):496-7IJ

Abstract

We have prospectively searched for IgA anti-transglutaminase antibodies by an enzyme-linked immunosorbent assay test in 20 untreated coeliacs and 21 patients with small bowel diseases other than coeliac disease consecutively referred to our Malabsorption Clinic. All the untreated coeliacs and one out of 21 disease controls turned out to be positive for the presence of these antibodies. The use of the enzyme-linked immunosorbent assay test for anti-transglutaminase antibodies could represent a new screening test for coeliac disease, in fact, this new enzyme-linked immunosorbent assay test has an absolute sensitivity and a satisfactory specificity and, in comparison to antiendomysial antibodies, is less expensive and avoids the ethical problems related to the use of monkey oesophagus.

Authors+Show Affiliations

Department of Internal Medicine, University of L'Aquila, Catania, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9836104

Citation

Brusco, G, et al. "Tissue Transglutaminase Antibodies for Coeliac Disease Screening." Italian Journal of Gastroenterology and Hepatology, vol. 30, no. 5, 1998, pp. 496-7.
Brusco G, Izzi L, Corazza GR. Tissue transglutaminase antibodies for coeliac disease screening. Ital J Gastroenterol Hepatol. 1998;30(5):496-7.
Brusco, G., Izzi, L., & Corazza, G. R. (1998). Tissue transglutaminase antibodies for coeliac disease screening. Italian Journal of Gastroenterology and Hepatology, 30(5), pp. 496-7.
Brusco G, Izzi L, Corazza GR. Tissue Transglutaminase Antibodies for Coeliac Disease Screening. Ital J Gastroenterol Hepatol. 1998;30(5):496-7. PubMed PMID: 9836104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue transglutaminase antibodies for coeliac disease screening. AU - Brusco,G, AU - Izzi,L, AU - Corazza,G R, PY - 1998/12/4/pubmed PY - 1998/12/4/medline PY - 1998/12/4/entrez SP - 496 EP - 7 JF - Italian journal of gastroenterology and hepatology JO - Ital J Gastroenterol Hepatol VL - 30 IS - 5 N2 - We have prospectively searched for IgA anti-transglutaminase antibodies by an enzyme-linked immunosorbent assay test in 20 untreated coeliacs and 21 patients with small bowel diseases other than coeliac disease consecutively referred to our Malabsorption Clinic. All the untreated coeliacs and one out of 21 disease controls turned out to be positive for the presence of these antibodies. The use of the enzyme-linked immunosorbent assay test for anti-transglutaminase antibodies could represent a new screening test for coeliac disease, in fact, this new enzyme-linked immunosorbent assay test has an absolute sensitivity and a satisfactory specificity and, in comparison to antiendomysial antibodies, is less expensive and avoids the ethical problems related to the use of monkey oesophagus. SN - 1125-8055 UR - https://www.unboundmedicine.com/medline/citation/9836104/Tissue_transglutaminase_antibodies_for_coeliac_disease_screening_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -