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Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats.
Biosci Biotechnol Biochem 1998; 62(10):1917-24BB

Abstract

We examined the effect of three dietary fats, safflower oil (SAF) rich in linoleic acid, borage oil (BOR) rich in gamma-linolenic acid, and perilla oil (PER) rich in alpha-linolenic acid, on the lipid metabolism, and chemical mediator and immunoglobulin levels in Sprague-Dawley rats, as well as the dietary effect of sesame-derived antioxidative sesamin. The serum cholesterol, phospholipid, triglyceride, prostaglandin E2 level and splenic leukotriene B4 level were lower in the rats fed on BOR or PER than in those fed on SAF. SES feeding suppressed the expression of the lipid-decreasing effect of BOR, but not in the rats fed on PER. In respect of the fatty acid composition of the liver and spleen, PER feeding gave a lower arachidonic acid level, and higher eicosapentaenoic and docosahexaenoic acid levels than SAF feeding did, while the effect of BOR feeding was marginal. The effect of SES feeding on fatty acid composition was much smaller than that of dietary fats. In respect of immunoglobulin production, PER + SES feeding gave the lowest IgE productivity in the mesenteric lymph node lymphocytes. These results suggest that PER feeding regulated lipid metabolism and exerted an anti-allergic effect by a different mechanism from that with BOR feeding.

Authors+Show Affiliations

Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9836427

Citation

Gu, J Y., et al. "Effect of Dietary Fats and Sesamin On the Lipid Metabolism and Immune Function of Sprague-Dawley Rats." Bioscience, Biotechnology, and Biochemistry, vol. 62, no. 10, 1998, pp. 1917-24.
Gu JY, Wakizono Y, Dohi A, et al. Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. Biosci Biotechnol Biochem. 1998;62(10):1917-24.
Gu, J. Y., Wakizono, Y., Dohi, A., Nonaka, M., Sugano, M., & Yamada, K. (1998). Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. Bioscience, Biotechnology, and Biochemistry, 62(10), pp. 1917-24.
Gu JY, et al. Effect of Dietary Fats and Sesamin On the Lipid Metabolism and Immune Function of Sprague-Dawley Rats. Biosci Biotechnol Biochem. 1998;62(10):1917-24. PubMed PMID: 9836427.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. AU - Gu,J Y, AU - Wakizono,Y, AU - Dohi,A, AU - Nonaka,M, AU - Sugano,M, AU - Yamada,K, PY - 1998/12/4/pubmed PY - 1998/12/4/medline PY - 1998/12/4/entrez SP - 1917 EP - 24 JF - Bioscience, biotechnology, and biochemistry JO - Biosci. Biotechnol. Biochem. VL - 62 IS - 10 N2 - We examined the effect of three dietary fats, safflower oil (SAF) rich in linoleic acid, borage oil (BOR) rich in gamma-linolenic acid, and perilla oil (PER) rich in alpha-linolenic acid, on the lipid metabolism, and chemical mediator and immunoglobulin levels in Sprague-Dawley rats, as well as the dietary effect of sesame-derived antioxidative sesamin. The serum cholesterol, phospholipid, triglyceride, prostaglandin E2 level and splenic leukotriene B4 level were lower in the rats fed on BOR or PER than in those fed on SAF. SES feeding suppressed the expression of the lipid-decreasing effect of BOR, but not in the rats fed on PER. In respect of the fatty acid composition of the liver and spleen, PER feeding gave a lower arachidonic acid level, and higher eicosapentaenoic and docosahexaenoic acid levels than SAF feeding did, while the effect of BOR feeding was marginal. The effect of SES feeding on fatty acid composition was much smaller than that of dietary fats. In respect of immunoglobulin production, PER + SES feeding gave the lowest IgE productivity in the mesenteric lymph node lymphocytes. These results suggest that PER feeding regulated lipid metabolism and exerted an anti-allergic effect by a different mechanism from that with BOR feeding. SN - 0916-8451 UR - https://www.unboundmedicine.com/medline/citation/9836427/Effect_of_dietary_fats_and_sesamin_on_the_lipid_metabolism_and_immune_function_of_Sprague_Dawley_rats_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/62.1917?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -