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Functional study of the gastric mucosal barrier in hepatic cirrhosis.
Acta Hepatogastroenterol (Stuttg). 1976 Sep-Oct; 23(5):351-9.AH

Abstract

The net ionic flux through the gastric wall was determined in eleven patients with hepatic cirrhosis and five normal controls. The back-diffusion of C1- and H+ was significantly increased in the cirrhotic group. In nine patients of this group the H+ loss was above the upper limits of normal. The Na+ flux was positive in both the control and the cirrhotic group. The Na+ flux towards the gastric cavity in the cirrhotic patients was not proportional to the loss of H+. Vasodilatation and edema of the lamina propria was always present as judged by gastric biopsy; in five cases mucosal hemorrhage was observed, in three superficial epithelial desquamation and in one melaena due to hemorrhagic gastritis. One the basis of the increase in H+ loss and the histological findings, we suspect an alteration in the gastric mucosal barrier in the patients with hepatic cirrhosis.

Authors

Solis-Herruzo JA
No affiliation info available
Pardo-Rueda J
No affiliation info available

MeSH

Biological TransportChloridesGastric JuiceGastric MucosaHumansHydrogenLiver CirrhosisPotassiumSodium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

983663

Citation

Solis-Herruzo, J A., and J Pardo-Rueda. "Functional Study of the Gastric Mucosal Barrier in Hepatic Cirrhosis." Acta Hepato-gastroenterologica, vol. 23, no. 5, 1976, pp. 351-9.
Solis-Herruzo JA, Pardo-Rueda J. Functional study of the gastric mucosal barrier in hepatic cirrhosis. Acta Hepatogastroenterol (Stuttg). 1976;23(5):351-9.
Solis-Herruzo, J. A., & Pardo-Rueda, J. (1976). Functional study of the gastric mucosal barrier in hepatic cirrhosis. Acta Hepato-gastroenterologica, 23(5), 351-9.
Solis-Herruzo JA, Pardo-Rueda J. Functional Study of the Gastric Mucosal Barrier in Hepatic Cirrhosis. Acta Hepatogastroenterol (Stuttg). 1976 Sep-Oct;23(5):351-9. PubMed PMID: 983663.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional study of the gastric mucosal barrier in hepatic cirrhosis. AU - Solis-Herruzo,J A, AU - Pardo-Rueda,J, PY - 1976/9/1/pubmed PY - 1976/9/1/medline PY - 1976/9/1/entrez SP - 351 EP - 9 JF - Acta hepato-gastroenterologica JO - Acta Hepatogastroenterol (Stuttg) VL - 23 IS - 5 N2 - The net ionic flux through the gastric wall was determined in eleven patients with hepatic cirrhosis and five normal controls. The back-diffusion of C1- and H+ was significantly increased in the cirrhotic group. In nine patients of this group the H+ loss was above the upper limits of normal. The Na+ flux was positive in both the control and the cirrhotic group. The Na+ flux towards the gastric cavity in the cirrhotic patients was not proportional to the loss of H+. Vasodilatation and edema of the lamina propria was always present as judged by gastric biopsy; in five cases mucosal hemorrhage was observed, in three superficial epithelial desquamation and in one melaena due to hemorrhagic gastritis. One the basis of the increase in H+ loss and the histological findings, we suspect an alteration in the gastric mucosal barrier in the patients with hepatic cirrhosis. SN - 0300-970X UR - https://www.unboundmedicine.com/medline/citation/983663/Functional_study_of_the_gastric_mucosal_barrier_in_hepatic_cirrhosis_ DB - PRIME DP - Unbound Medicine ER -