Tags

Type your tag names separated by a space and hit enter

Assessment of hypothalamic-pituitary function by hormonal pulsatility, gonadotropin-releasing hormone and thyrotropin-releasing hormone testing in women with euprolactinemic secondary amenorrhea.
Kaohsiung J Med Sci. 1998 Nov; 14(11):698-705.KJ

Abstract

To evaluate the integrated hypothalamic-pituitary function of euprolactinemic secondary amenorrhea, blood samples of 23 patients were taken every 15 min for 4 hours in examination of pulsatile LH, FSH, PRL secretions and then 2 hours GnRH, TRH tests were performed. Nine normal cycling women (group I) served as the controls. Thirteen amenorrheic women (group II) revealed responsive bleeding to progestin injection and the other 10 women (group III) were nonresponsive. The LH frequency, amplitude, and LH response to GnRH of groups II and I were comparable, whereas delta PRL after TRH in group II (60.8 +/- 18.9 ng/ml) exhibited a significantly (P < 0.05) exaggerated response, as compared with that of group I (43.6 +/- 11.4 ng/ml). The LH frequency (1.3 +/- 0.4/4h) and amplitude (1.7 +/- 0.4 mIU/mL) of group III were significantly lower (P < 0.01) than those in group I (2.4 +/- 0.5 and 2.5 +/- 0.5, respectively), but their delta LH and delta FSH responses to GnRH showed no differences from those of controls. The frequency, amplitude of PRL and delta PRL response to TRH in group III were no significant difference with those of group I. These results suggest that masked PRL hypersecretion and loss of the regulatory pulsatility of gonadotropin release may be responsible in part for the causes resulting to euprolactinemic secondary amenorrhea. The analysis of these hormonal environments is useful for the understanding of clinical perspectives, pathophysiology and management.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Kaohsiung Medical College, Taiwan, Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9838765

Citation

Lin, K C., et al. "Assessment of Hypothalamic-pituitary Function By Hormonal Pulsatility, Gonadotropin-releasing Hormone and Thyrotropin-releasing Hormone Testing in Women With Euprolactinemic Secondary Amenorrhea." The Kaohsiung Journal of Medical Sciences, vol. 14, no. 11, 1998, pp. 698-705.
Lin KC, Lee JN, Jong SB. Assessment of hypothalamic-pituitary function by hormonal pulsatility, gonadotropin-releasing hormone and thyrotropin-releasing hormone testing in women with euprolactinemic secondary amenorrhea. Kaohsiung J Med Sci. 1998;14(11):698-705.
Lin, K. C., Lee, J. N., & Jong, S. B. (1998). Assessment of hypothalamic-pituitary function by hormonal pulsatility, gonadotropin-releasing hormone and thyrotropin-releasing hormone testing in women with euprolactinemic secondary amenorrhea. The Kaohsiung Journal of Medical Sciences, 14(11), 698-705.
Lin KC, Lee JN, Jong SB. Assessment of Hypothalamic-pituitary Function By Hormonal Pulsatility, Gonadotropin-releasing Hormone and Thyrotropin-releasing Hormone Testing in Women With Euprolactinemic Secondary Amenorrhea. Kaohsiung J Med Sci. 1998;14(11):698-705. PubMed PMID: 9838765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of hypothalamic-pituitary function by hormonal pulsatility, gonadotropin-releasing hormone and thyrotropin-releasing hormone testing in women with euprolactinemic secondary amenorrhea. AU - Lin,K C, AU - Lee,J N, AU - Jong,S B, PY - 1998/12/5/pubmed PY - 1998/12/5/medline PY - 1998/12/5/entrez SP - 698 EP - 705 JF - The Kaohsiung journal of medical sciences JO - Kaohsiung J Med Sci VL - 14 IS - 11 N2 - To evaluate the integrated hypothalamic-pituitary function of euprolactinemic secondary amenorrhea, blood samples of 23 patients were taken every 15 min for 4 hours in examination of pulsatile LH, FSH, PRL secretions and then 2 hours GnRH, TRH tests were performed. Nine normal cycling women (group I) served as the controls. Thirteen amenorrheic women (group II) revealed responsive bleeding to progestin injection and the other 10 women (group III) were nonresponsive. The LH frequency, amplitude, and LH response to GnRH of groups II and I were comparable, whereas delta PRL after TRH in group II (60.8 +/- 18.9 ng/ml) exhibited a significantly (P < 0.05) exaggerated response, as compared with that of group I (43.6 +/- 11.4 ng/ml). The LH frequency (1.3 +/- 0.4/4h) and amplitude (1.7 +/- 0.4 mIU/mL) of group III were significantly lower (P < 0.01) than those in group I (2.4 +/- 0.5 and 2.5 +/- 0.5, respectively), but their delta LH and delta FSH responses to GnRH showed no differences from those of controls. The frequency, amplitude of PRL and delta PRL response to TRH in group III were no significant difference with those of group I. These results suggest that masked PRL hypersecretion and loss of the regulatory pulsatility of gonadotropin release may be responsible in part for the causes resulting to euprolactinemic secondary amenorrhea. The analysis of these hormonal environments is useful for the understanding of clinical perspectives, pathophysiology and management. SN - 1607-551X UR - https://www.unboundmedicine.com/medline/citation/9838765/Assessment_of_hypothalamic_pituitary_function_by_hormonal_pulsatility_gonadotropin_releasing_hormone_and_thyrotropin_releasing_hormone_testing_in_women_with_euprolactinemic_secondary_amenorrhea_ DB - PRIME DP - Unbound Medicine ER -