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Isolation of antitumor polysaccharide fractions from Yucca glauca Nutt. (Lilliaceae).
Growth. 1978 Jun; 42(2):213-23.G

Abstract

An aqueous alcoholic extract of fresh flowers of Yucca glauca Nutt. showed striking antitumor activity against B16 melanoma in mice. Systematic fractionation of the extract by means of solvent extraction and gel permeation chromatography led to separation of two galactose containing polysaccharide fractions with marked inhibitory activity against B16 melanoma in mice. The extraction, fractionation, purification and preliminary characterization of the active polysaccharide fractions are described. The materials showed no activity against L1210 or P388 leukemias in mice. The implications of the findings for searches for both natural and synthetic anticancer agents are discussed.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

98392

Citation

Ali, M S., et al. "Isolation of Antitumor Polysaccharide Fractions From Yucca Glauca Nutt. (Lilliaceae)." Growth, vol. 42, no. 2, 1978, pp. 213-23.
Ali MS, Sharma GC, Asplund RO, et al. Isolation of antitumor polysaccharide fractions from Yucca glauca Nutt. (Lilliaceae). Growth. 1978;42(2):213-23.
Ali, M. S., Sharma, G. C., Asplund, R. O., Nevins, M. P., & Garb, S. (1978). Isolation of antitumor polysaccharide fractions from Yucca glauca Nutt. (Lilliaceae). Growth, 42(2), 213-23.
Ali MS, et al. Isolation of Antitumor Polysaccharide Fractions From Yucca Glauca Nutt. (Lilliaceae). Growth. 1978;42(2):213-23. PubMed PMID: 98392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of antitumor polysaccharide fractions from Yucca glauca Nutt. (Lilliaceae). AU - Ali,M S, AU - Sharma,G C, AU - Asplund,R O, AU - Nevins,M P, AU - Garb,S, PY - 1978/6/1/pubmed PY - 1978/6/1/medline PY - 1978/6/1/entrez SP - 213 EP - 23 JF - Growth JO - Growth VL - 42 IS - 2 N2 - An aqueous alcoholic extract of fresh flowers of Yucca glauca Nutt. showed striking antitumor activity against B16 melanoma in mice. Systematic fractionation of the extract by means of solvent extraction and gel permeation chromatography led to separation of two galactose containing polysaccharide fractions with marked inhibitory activity against B16 melanoma in mice. The extraction, fractionation, purification and preliminary characterization of the active polysaccharide fractions are described. The materials showed no activity against L1210 or P388 leukemias in mice. The implications of the findings for searches for both natural and synthetic anticancer agents are discussed. SN - 0017-4793 UR - https://www.unboundmedicine.com/medline/citation/98392/Isolation_of_antitumor_polysaccharide_fractions_from_Yucca_glauca_Nutt___Lilliaceae__ DB - PRIME DP - Unbound Medicine ER -