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Effect of adequate alcohol intake, with or without cigarette smoking, on the risk of Helicobacter pylori infection.

Abstract

BACKGROUND/AIMS

Chronic adequate alcohol intake induces an "adaptive cytoprotection", mediated by endogenous release of prostaglandins and increased activity of gastric antioxidants, that reduces the mucosal damage caused by higher ethanol concentrations. The aim of our study was to verify the presence of a protection against Helicobacter pylori infection, induced by adequate alcohol consumption, with or without cigarette smoking.

METHODOLOGY

We studied 303 consecutive dyspeptic patients, who underwent gastroscopy for the first time. The patients were allocated to four groups: A) 57 with adequate alcohol consumption; B) 88 smokers pts; C) 64 smokers pts with adequate alcohol consumption; D) 93 non-smokers and teetotalers.

RESULTS

H. pylori infection was found in 32 pts of group A (56.14%), 67 of group B (77.13%), 46 of group C (71.87%) and 61 of group D (65.69%). There was a statistical significant difference in H. pylori-positivity only between group A and group B (p=0.019).

CONCLUSIONS

Even if we noted a statistical difference only between group A and B, however the lower prevalence of H. pylori infection in group A than in other groups suggests a protective mechanism of adequate alcohol consumption, mediated by "adaptive cytoprotection", which reduces the risk of H. pylori infection.

Authors+Show Affiliations

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Department of Internal Medicine, Policlinico A.Gemelli Catholic University S. C., Rome, Italy.

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Source

Hepato-gastroenterology 45:23 pg 1892-5

MeSH

Adolescent
Adult
Aged
Aged, 80 and over
Alcohol Drinking
Cytoprotection
Duodenal Ulcer
Ethanol
Female
Gastric Mucosa
Helicobacter Infections
Helicobacter pylori
Humans
Male
Middle Aged
Risk Factors
Smoking
Stomach Ulcer

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9840171

Citation

Tursi, A, et al. "Effect of Adequate Alcohol Intake, With or Without Cigarette Smoking, On the Risk of Helicobacter Pylori Infection." Hepato-gastroenterology, vol. 45, no. 23, 1998, pp. 1892-5.
Tursi A, Cammarota G, Papa A, et al. Effect of adequate alcohol intake, with or without cigarette smoking, on the risk of Helicobacter pylori infection. Hepatogastroenterology. 1998;45(23):1892-5.
Tursi, A., Cammarota, G., Papa, A., Cianci, R., Cuoco, L., Fedeli, G., & Gasbarrini, G. (1998). Effect of adequate alcohol intake, with or without cigarette smoking, on the risk of Helicobacter pylori infection. Hepato-gastroenterology, 45(23), pp. 1892-5.
Tursi A, et al. Effect of Adequate Alcohol Intake, With or Without Cigarette Smoking, On the Risk of Helicobacter Pylori Infection. Hepatogastroenterology. 1998;45(23):1892-5. PubMed PMID: 9840171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of adequate alcohol intake, with or without cigarette smoking, on the risk of Helicobacter pylori infection. AU - Tursi,A, AU - Cammarota,G, AU - Papa,A, AU - Cianci,R, AU - Cuoco,L, AU - Fedeli,G, AU - Gasbarrini,G, PY - 1998/12/5/pubmed PY - 1998/12/5/medline PY - 1998/12/5/entrez SP - 1892 EP - 5 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 45 IS - 23 N2 - BACKGROUND/AIMS: Chronic adequate alcohol intake induces an "adaptive cytoprotection", mediated by endogenous release of prostaglandins and increased activity of gastric antioxidants, that reduces the mucosal damage caused by higher ethanol concentrations. The aim of our study was to verify the presence of a protection against Helicobacter pylori infection, induced by adequate alcohol consumption, with or without cigarette smoking. METHODOLOGY: We studied 303 consecutive dyspeptic patients, who underwent gastroscopy for the first time. The patients were allocated to four groups: A) 57 with adequate alcohol consumption; B) 88 smokers pts; C) 64 smokers pts with adequate alcohol consumption; D) 93 non-smokers and teetotalers. RESULTS: H. pylori infection was found in 32 pts of group A (56.14%), 67 of group B (77.13%), 46 of group C (71.87%) and 61 of group D (65.69%). There was a statistical significant difference in H. pylori-positivity only between group A and group B (p=0.019). CONCLUSIONS: Even if we noted a statistical difference only between group A and B, however the lower prevalence of H. pylori infection in group A than in other groups suggests a protective mechanism of adequate alcohol consumption, mediated by "adaptive cytoprotection", which reduces the risk of H. pylori infection. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/9840171/full_citation L2 - https://medlineplus.gov/alcohol.html DB - PRIME DP - Unbound Medicine ER -