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Risk evaluation of postvagotomy ulcer recurrence by using endoscopic Congo red test and gastric secretion tests.
Hepatogastroenterology. 1998 Sep-Oct; 45(23):1912-7.H

Abstract

BACKGROUND/AIMS

To evaluate the usefulness of the endoscopic Congo red test (ECRT), and to compare sensitivity and specificity of different tests in the discrimination of cases with high risk for postvagotomy recurrent ulcer (RU).

METHODOLOGY

In 271 consecutive postvagotomy duodenal ulcer patients the endoscopic Congo red test (ECRT) was used 5-12 years after vagotomy. Further, 39 patients out of 271 were selected and classified into two groups: A--13 ECRT positive cases with RU, B--26 controls without RU (13 ECRT positive and 13 ECRT negative cases). Basal acid output (BAO), maximal acid output (MAO), and nocturnal acid output (NAO) were determined pre- and postoperatively, the serum pepsinogen I (S-PGI) and insulin test were estimated postoperatively.

RESULTS

Positive ECRT had 95% sensitivity and 53% specificity for RU. S-PGI > 150 microg/l had 54% sensitivity and 92% specificity (in ECRT positive cases 100% specificity). The insulin test showed 83% sensitivity and 78% specificity. The respective data for the combination of BAO > 1.5 mmol/h + NAO > 30 mmol/12 h were 80% and 81%.

CONCLUSION

ECRT should be a primary step in estimating postvagotomy ulcer risk. In negative ECRT cases, the development of recurrent ulcer is unlikely. Additional gastric secretion studies as S-PGI or BAO+NAO or insulin test are needed only in ECRT positive cases.

Authors+Show Affiliations

Department of Surgery, University of Tartu, Estonia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9840175

Citation

Peetsalu, A, et al. "Risk Evaluation of Postvagotomy Ulcer Recurrence By Using Endoscopic Congo Red Test and Gastric Secretion Tests." Hepato-gastroenterology, vol. 45, no. 23, 1998, pp. 1912-7.
Peetsalu A, Harkonen M, Peetsalu M, et al. Risk evaluation of postvagotomy ulcer recurrence by using endoscopic Congo red test and gastric secretion tests. Hepatogastroenterology. 1998;45(23):1912-7.
Peetsalu, A., Harkonen, M., Peetsalu, M., & Varis, K. (1998). Risk evaluation of postvagotomy ulcer recurrence by using endoscopic Congo red test and gastric secretion tests. Hepato-gastroenterology, 45(23), 1912-7.
Peetsalu A, et al. Risk Evaluation of Postvagotomy Ulcer Recurrence By Using Endoscopic Congo Red Test and Gastric Secretion Tests. Hepatogastroenterology. 1998 Sep-Oct;45(23):1912-7. PubMed PMID: 9840175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk evaluation of postvagotomy ulcer recurrence by using endoscopic Congo red test and gastric secretion tests. AU - Peetsalu,A, AU - Harkonen,M, AU - Peetsalu,M, AU - Varis,K, PY - 1998/12/5/pubmed PY - 1998/12/5/medline PY - 1998/12/5/entrez SP - 1912 EP - 7 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 45 IS - 23 N2 - BACKGROUND/AIMS: To evaluate the usefulness of the endoscopic Congo red test (ECRT), and to compare sensitivity and specificity of different tests in the discrimination of cases with high risk for postvagotomy recurrent ulcer (RU). METHODOLOGY: In 271 consecutive postvagotomy duodenal ulcer patients the endoscopic Congo red test (ECRT) was used 5-12 years after vagotomy. Further, 39 patients out of 271 were selected and classified into two groups: A--13 ECRT positive cases with RU, B--26 controls without RU (13 ECRT positive and 13 ECRT negative cases). Basal acid output (BAO), maximal acid output (MAO), and nocturnal acid output (NAO) were determined pre- and postoperatively, the serum pepsinogen I (S-PGI) and insulin test were estimated postoperatively. RESULTS: Positive ECRT had 95% sensitivity and 53% specificity for RU. S-PGI > 150 microg/l had 54% sensitivity and 92% specificity (in ECRT positive cases 100% specificity). The insulin test showed 83% sensitivity and 78% specificity. The respective data for the combination of BAO > 1.5 mmol/h + NAO > 30 mmol/12 h were 80% and 81%. CONCLUSION: ECRT should be a primary step in estimating postvagotomy ulcer risk. In negative ECRT cases, the development of recurrent ulcer is unlikely. Additional gastric secretion studies as S-PGI or BAO+NAO or insulin test are needed only in ECRT positive cases. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/9840175/Risk_evaluation_of_postvagotomy_ulcer_recurrence_by_using_endoscopic_Congo_red_test_and_gastric_secretion_tests_ L2 - https://antibodies.cancer.gov/detail/CPTC-GPI-1 DB - PRIME DP - Unbound Medicine ER -