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Onset of psychopathology in offspring by developmental phase and parental depression.
J Am Acad Child Adolesc Psychiatry. 1998 Sep; 37(9):933-42.JA

Abstract

OBJECTIVE

To determine the differential effects of parental major depression (MDD) on psychopathology of childhood, adolescent, and early-adult onset in offspring.

METHOD

One hundred eighty-two offspring from 91 families in which one or more parents or neither parent had MDD were followed for more than 10 years and blindly reassessed by means of a structured diagnostic instrument.

RESULTS

Parental MDD is associated with increased risk in offspring of childhood-onset MDD (eightfold), anxiety disorder (threefold), conduct disorder (fivefold), and early-adult-onset MDD (fivefold) but not adolescent-onset MDD, where there is a marked increase in risk, particularly in girls, regardless of parental diagnosis. These findings were not explained by parental comorbidity, but the association with MDD was explained by parental age at onset of MDD--there was a 13-fold increase in childhood-onset MDD and a 7-fold increase in adult-onset MDD in offspring of parents with MDD of early (before age 30 years) onset.

CONCLUSION

Childhood- and early-adult-onset MDD may be etiologically homogeneous and familial subtypes. The reason for the high incidence of adolescent-onset MDD, particularly in girls, regardless of parental diagnosis, needs to be determined. The childhood offspring of depressed parents are a potential target for evaluation, especially when the parent had an early-onset depression.

Authors+Show Affiliations

New York State Psychiatric Institute, New York, New York 10032, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9841243

Citation

Wickramaratne, P J., and M M. Weissman. "Onset of Psychopathology in Offspring By Developmental Phase and Parental Depression." Journal of the American Academy of Child and Adolescent Psychiatry, vol. 37, no. 9, 1998, pp. 933-42.
Wickramaratne PJ, Weissman MM. Onset of psychopathology in offspring by developmental phase and parental depression. J Am Acad Child Adolesc Psychiatry. 1998;37(9):933-42.
Wickramaratne, P. J., & Weissman, M. M. (1998). Onset of psychopathology in offspring by developmental phase and parental depression. Journal of the American Academy of Child and Adolescent Psychiatry, 37(9), 933-42.
Wickramaratne PJ, Weissman MM. Onset of Psychopathology in Offspring By Developmental Phase and Parental Depression. J Am Acad Child Adolesc Psychiatry. 1998;37(9):933-42. PubMed PMID: 9841243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Onset of psychopathology in offspring by developmental phase and parental depression. AU - Wickramaratne,P J, AU - Weissman,M M, PY - 1998/12/5/pubmed PY - 1998/12/5/medline PY - 1998/12/5/entrez SP - 933 EP - 42 JF - Journal of the American Academy of Child and Adolescent Psychiatry JO - J Am Acad Child Adolesc Psychiatry VL - 37 IS - 9 N2 - OBJECTIVE: To determine the differential effects of parental major depression (MDD) on psychopathology of childhood, adolescent, and early-adult onset in offspring. METHOD: One hundred eighty-two offspring from 91 families in which one or more parents or neither parent had MDD were followed for more than 10 years and blindly reassessed by means of a structured diagnostic instrument. RESULTS: Parental MDD is associated with increased risk in offspring of childhood-onset MDD (eightfold), anxiety disorder (threefold), conduct disorder (fivefold), and early-adult-onset MDD (fivefold) but not adolescent-onset MDD, where there is a marked increase in risk, particularly in girls, regardless of parental diagnosis. These findings were not explained by parental comorbidity, but the association with MDD was explained by parental age at onset of MDD--there was a 13-fold increase in childhood-onset MDD and a 7-fold increase in adult-onset MDD in offspring of parents with MDD of early (before age 30 years) onset. CONCLUSION: Childhood- and early-adult-onset MDD may be etiologically homogeneous and familial subtypes. The reason for the high incidence of adolescent-onset MDD, particularly in girls, regardless of parental diagnosis, needs to be determined. The childhood offspring of depressed parents are a potential target for evaluation, especially when the parent had an early-onset depression. SN - 0890-8567 UR - https://www.unboundmedicine.com/medline/citation/9841243/Onset_of_psychopathology_in_offspring_by_developmental_phase_and_parental_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-8567(09)62777-5 DB - PRIME DP - Unbound Medicine ER -