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Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans.
Am J Physiol. 1998 12; 275(6):G1266-73.AJ

Abstract

Transient lower esophageal sphincter (LES) relaxations (TLESRs) are the main underlying mechanism of gastroesophageal reflux. Although CCK acts through CCK-A receptors to increase the TLESRs induced by gastric distension, the respective roles of endogenous CCK and fundic tone in triggering postprandial TLESRs remain unknown. The aim of this study was to determine the effect of the CCK-A receptor antagonist, loxiglumide, on postprandial LES function and fundic tone in humans. LES motor events and fundic tone were simultaneously monitored in two groups of healthy volunteers. Recordings were performed during fasting and for 3 h after a liquid meal (200 ml/200 kcal) administered either orally or intraduodenally at a rate mimicking gastric emptying. Each subject received loxiglumide (10 mg. kg-1. h-1) or saline (control) in randomized order, which was started 40 min before the meal and maintained for 3 h thereafter. After the oral meal, loxiglumide significantly reduced TLESRs (P = 0.002) without significantly affecting LES pressure and fundic tone. After duodenal infusion of the meal, loxiglumide totally abolished the increase in TLESRs, reduced LES pressure fall (P < 0.02), and strongly inhibited fundic relaxation (P = 0.0001). We concluded that endogenous CCK is involved in the postprandial control of both LES function and fundic tone through activation of CCK-A receptors.

Authors+Show Affiliations

Human Nutrition Research Center and Department of Gastroenterology and Hepatology, University of Nantes, 44035 Nantes, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9843762

Citation

Zerbib, F, et al. "Endogenous Cholecystokinin in Postprandial Lower Esophageal Sphincter Function and Fundic Tone in Humans." The American Journal of Physiology, vol. 275, no. 6, 1998, pp. G1266-73.
Zerbib F, Bruley Des Varannes S, Scarpignato C, et al. Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans. Am J Physiol. 1998;275(6):G1266-73.
Zerbib, F., Bruley Des Varannes, S., Scarpignato, C., Leray, V., D'Amato, M., Rozé, C., & Galmiche, J. P. (1998). Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans. The American Journal of Physiology, 275(6), G1266-73. https://doi.org/10.1152/ajpgi.1998.275.6.G1266
Zerbib F, et al. Endogenous Cholecystokinin in Postprandial Lower Esophageal Sphincter Function and Fundic Tone in Humans. Am J Physiol. 1998;275(6):G1266-73. PubMed PMID: 9843762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans. AU - Zerbib,F, AU - Bruley Des Varannes,S, AU - Scarpignato,C, AU - Leray,V, AU - D'Amato,M, AU - Rozé,C, AU - Galmiche,J P, PY - 1998/12/9/pubmed PY - 1998/12/9/medline PY - 1998/12/9/entrez SP - G1266 EP - 73 JF - The American journal of physiology JO - Am J Physiol VL - 275 IS - 6 N2 - Transient lower esophageal sphincter (LES) relaxations (TLESRs) are the main underlying mechanism of gastroesophageal reflux. Although CCK acts through CCK-A receptors to increase the TLESRs induced by gastric distension, the respective roles of endogenous CCK and fundic tone in triggering postprandial TLESRs remain unknown. The aim of this study was to determine the effect of the CCK-A receptor antagonist, loxiglumide, on postprandial LES function and fundic tone in humans. LES motor events and fundic tone were simultaneously monitored in two groups of healthy volunteers. Recordings were performed during fasting and for 3 h after a liquid meal (200 ml/200 kcal) administered either orally or intraduodenally at a rate mimicking gastric emptying. Each subject received loxiglumide (10 mg. kg-1. h-1) or saline (control) in randomized order, which was started 40 min before the meal and maintained for 3 h thereafter. After the oral meal, loxiglumide significantly reduced TLESRs (P = 0.002) without significantly affecting LES pressure and fundic tone. After duodenal infusion of the meal, loxiglumide totally abolished the increase in TLESRs, reduced LES pressure fall (P < 0.02), and strongly inhibited fundic relaxation (P = 0.0001). We concluded that endogenous CCK is involved in the postprandial control of both LES function and fundic tone through activation of CCK-A receptors. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/9843762/Endogenous_cholecystokinin_in_postprandial_lower_esophageal_sphincter_function_and_fundic_tone_in_humans_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.1998.275.6.G1266?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -