Tags

Type your tag names separated by a space and hit enter

Nonsteroidal anti-inflammatory drugs and bone mineral density in older women: the Rancho Bernardo study.
J Bone Miner Res 1998; 13(12):1924-31JB

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to inhibit synthesis of prostaglandins and may help prevent bone loss, but no study has shown the differential association of type or dose of NSAID compound with bone mineral density (BMD). The purpose of this study was to determine the relation of NSAIDs by type and dose to BMD. Participants were 932 Caucasian, community-dwelling women aged 44-98 years from southern California. Data were collected from 1988 to 1991 through the use of standardized medical questionnaires. Medication use was validated by a nurse. BMD at the ultradistal and midshaft radii were measured using single-photon absorptiometry, and at the hip and lumbar spine using dual-energy X-ray absorptiometry. Women (mean age, 72 years) were classified into 818 nonusers and 114 regular daily users of NSAIDs, of which 84 used propionic acid NSAIDs and the remainder used acetic acid NSAIDs. Occasional NSAID users were excluded. Women who used propionic acid NSAIDs, but not acetic acid NSAIDs, had higher BMD at all five sites and significantly higher BMD at the midshaft radius and lumbar spine. These differences remained after controlling for known covariates of osteoporosis. When women with self-reported osteoarthritis were excluded from the model, significantly higher BMD in propionic acid NSAID users was also observed at the femoral neck and total hip. Those who concurrently used estrogen and propionic acid NSAIDs had the highest BMD at all sites, suggesting an additive effect. We conclude that regular daily use of propionic acid NSAIDs, with or without simultaneous use of estrogen, may be helpful in preventing bone loss in older women. However, further research is needed to confirm these results before any clinical practice guidelines can be recommended due to the increased risk of serious complications associated with NSAID use.

Authors+Show Affiliations

University of California, San Diego, La Jolla, California 92093-0607, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9844111

Citation

Morton, D J., et al. "Nonsteroidal Anti-inflammatory Drugs and Bone Mineral Density in Older Women: the Rancho Bernardo Study." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 13, no. 12, 1998, pp. 1924-31.
Morton DJ, Barrett-Connor EL, Schneider DL. Nonsteroidal anti-inflammatory drugs and bone mineral density in older women: the Rancho Bernardo study. J Bone Miner Res. 1998;13(12):1924-31.
Morton, D. J., Barrett-Connor, E. L., & Schneider, D. L. (1998). Nonsteroidal anti-inflammatory drugs and bone mineral density in older women: the Rancho Bernardo study. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 13(12), pp. 1924-31.
Morton DJ, Barrett-Connor EL, Schneider DL. Nonsteroidal Anti-inflammatory Drugs and Bone Mineral Density in Older Women: the Rancho Bernardo Study. J Bone Miner Res. 1998;13(12):1924-31. PubMed PMID: 9844111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonsteroidal anti-inflammatory drugs and bone mineral density in older women: the Rancho Bernardo study. AU - Morton,D J, AU - Barrett-Connor,E L, AU - Schneider,D L, PY - 1998/12/9/pubmed PY - 1998/12/9/medline PY - 1998/12/9/entrez SP - 1924 EP - 31 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 13 IS - 12 N2 - Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to inhibit synthesis of prostaglandins and may help prevent bone loss, but no study has shown the differential association of type or dose of NSAID compound with bone mineral density (BMD). The purpose of this study was to determine the relation of NSAIDs by type and dose to BMD. Participants were 932 Caucasian, community-dwelling women aged 44-98 years from southern California. Data were collected from 1988 to 1991 through the use of standardized medical questionnaires. Medication use was validated by a nurse. BMD at the ultradistal and midshaft radii were measured using single-photon absorptiometry, and at the hip and lumbar spine using dual-energy X-ray absorptiometry. Women (mean age, 72 years) were classified into 818 nonusers and 114 regular daily users of NSAIDs, of which 84 used propionic acid NSAIDs and the remainder used acetic acid NSAIDs. Occasional NSAID users were excluded. Women who used propionic acid NSAIDs, but not acetic acid NSAIDs, had higher BMD at all five sites and significantly higher BMD at the midshaft radius and lumbar spine. These differences remained after controlling for known covariates of osteoporosis. When women with self-reported osteoarthritis were excluded from the model, significantly higher BMD in propionic acid NSAID users was also observed at the femoral neck and total hip. Those who concurrently used estrogen and propionic acid NSAIDs had the highest BMD at all sites, suggesting an additive effect. We conclude that regular daily use of propionic acid NSAIDs, with or without simultaneous use of estrogen, may be helpful in preventing bone loss in older women. However, further research is needed to confirm these results before any clinical practice guidelines can be recommended due to the increased risk of serious complications associated with NSAID use. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/9844111/Nonsteroidal_anti_inflammatory_drugs_and_bone_mineral_density_in_older_women:_the_Rancho_Bernardo_study_ L2 - https://doi.org/10.1359/jbmr.1998.13.12.1924 DB - PRIME DP - Unbound Medicine ER -