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Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia.
Exp Hematol. 1998 Dec; 26(13):1209-14.EH

Abstract

To extend the panel of monoclonal antibodies useful for immunophenotyping of acute leukemias, two new reagents, TC-12 and TH-111, were developed. TC-12 was found "unique," and TH-111 was assigned to the recently defined CD96 cluster. Both reagents show little reactivity with blood and bone marrow nucleated cells but define a major (TH-111: 78.3%) or an important (TC-12: 45.6%) subset of T-cell acute lymphoblastic leukemia (ALL). In addition, in acute myeloid leukemia (AML), the expression of TC-12 was found in 64 (20.2%) of 317 and TH-111 in 97 (29.1%) of 333 of these patients. TC-12 positivity in AML was virtually restricted to the Fab subtypes M0, M1, M2, and M6. In the group of immature AML characterized by the coexpression of CD7 as well as CD117 and CD34 positivity, leukemic blasts frequently disclosed the TC-12 and TH-111 antigen. Although the TC-12 antigen could not be determined, TH-111 immunoprecipitated the TACTILE (CD96) antigen and, when expressed, was found to be associated with the transferrin receptor. These reagents may help not only to define and dissect T-cell ALL, but also to characterize a subgroup of immature AML at the divergence of T-cell and myeloid lineage.

Authors+Show Affiliations

Department of Medicine III, University of Erlangen-Nürnberg, Erlangen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9845376

Citation

Gramatzki, M, et al. "Antibodies TC-12 ("unique") and TH-111 (CD96) Characterize T-cell Acute Lymphoblastic Leukemia and a Subgroup of Acute Myeloid Leukemia." Experimental Hematology, vol. 26, no. 13, 1998, pp. 1209-14.
Gramatzki M, Ludwig WD, Burger R, et al. Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. Exp Hematol. 1998;26(13):1209-14.
Gramatzki, M., Ludwig, W. D., Burger, R., Moos, P., Rohwer, P., Grünert, C., Sendler, A., Kalden, J. R., Andreesen, R., Henschke, F., & Moldenhauer, G. (1998). Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. Experimental Hematology, 26(13), 1209-14.
Gramatzki M, et al. Antibodies TC-12 ("unique") and TH-111 (CD96) Characterize T-cell Acute Lymphoblastic Leukemia and a Subgroup of Acute Myeloid Leukemia. Exp Hematol. 1998;26(13):1209-14. PubMed PMID: 9845376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antibodies TC-12 ("unique") and TH-111 (CD96) characterize T-cell acute lymphoblastic leukemia and a subgroup of acute myeloid leukemia. AU - Gramatzki,M, AU - Ludwig,W D, AU - Burger,R, AU - Moos,P, AU - Rohwer,P, AU - Grünert,C, AU - Sendler,A, AU - Kalden,J R, AU - Andreesen,R, AU - Henschke,F, AU - Moldenhauer,G, PY - 1998/12/9/pubmed PY - 1998/12/9/medline PY - 1998/12/9/entrez SP - 1209 EP - 14 JF - Experimental hematology JO - Exp Hematol VL - 26 IS - 13 N2 - To extend the panel of monoclonal antibodies useful for immunophenotyping of acute leukemias, two new reagents, TC-12 and TH-111, were developed. TC-12 was found "unique," and TH-111 was assigned to the recently defined CD96 cluster. Both reagents show little reactivity with blood and bone marrow nucleated cells but define a major (TH-111: 78.3%) or an important (TC-12: 45.6%) subset of T-cell acute lymphoblastic leukemia (ALL). In addition, in acute myeloid leukemia (AML), the expression of TC-12 was found in 64 (20.2%) of 317 and TH-111 in 97 (29.1%) of 333 of these patients. TC-12 positivity in AML was virtually restricted to the Fab subtypes M0, M1, M2, and M6. In the group of immature AML characterized by the coexpression of CD7 as well as CD117 and CD34 positivity, leukemic blasts frequently disclosed the TC-12 and TH-111 antigen. Although the TC-12 antigen could not be determined, TH-111 immunoprecipitated the TACTILE (CD96) antigen and, when expressed, was found to be associated with the transferrin receptor. These reagents may help not only to define and dissect T-cell ALL, but also to characterize a subgroup of immature AML at the divergence of T-cell and myeloid lineage. SN - 0301-472X UR - https://www.unboundmedicine.com/medline/citation/9845376/Antibodies_TC_12__"unique"__and_TH_111__CD96__characterize_T_cell_acute_lymphoblastic_leukemia_and_a_subgroup_of_acute_myeloid_leukemia_ L2 - https://web.expasy.org/cellosaurus/CVCL_WP00 DB - PRIME DP - Unbound Medicine ER -