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Effects of tablet and effervescent formulations of ranitidine 75 mg and cimetidine 200 mg on gastric acidity and oesophageal acid exposure in healthy humans.
Aliment Pharmacol Ther. 1998 Nov; 12(11):1155-61.AP

Abstract

BACKGROUND

Because of their tolerance and safety, low doses of H2-receptor antagonists are now increasingly used in some countries for self-care medication of gastro-oesophageal reflux symptoms.

AIM

The purpose of this randomized, double-blind, placebo-controlled, five-way crossover study was to determine and to compare the effects of low doses of ranitidine and cimetidine both on gastric pH and on oesophageal acid exposure.

METHODS

Gastric and oesophageal pH were simultaneously monitored in 20 healthy subjects using two glass pH electrodes, after placebo and single doses of ranitidine 75 mg and cimetidine 200 mg (effervescent and tablet forms), for 4 h before and after a meal.

RESULTS

During the fasting period, median gastric pH rose significantly with both drugs, but more rapidly with the effervescent forms; the oesophageal acid exposure was significantly decreased by all drug regimens. After the meal, although there was no significant difference in gastric pH values, oesophageal acid exposure was significantly decreased in comparison with placebo with both forms of ranitidine (P < 0.05), and also for ranitidine tablets in comparison with cimetidine tablets (P < 0.05).

CONCLUSIONS

Low doses of ranitidine and cimetidine increase gastric pH, with a more pronounced effect for ranitidine. Effervescent formulations of both drugs induce a slightly more rapid initial increase in pH than tablets. Ranitidine demonstrates a more prolonged effect than cimetidine and decreases oesophageal acid exposure monitored after a meal ingested 4 h after the drug intake.

Authors+Show Affiliations

Department of Gastroenterology & Hepatology, College of Medicine, University of Nantes, France. bruley@easynet.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9845405

Citation

Bruley des Varannes, S, et al. "Effects of Tablet and Effervescent Formulations of Ranitidine 75 Mg and Cimetidine 200 Mg On Gastric Acidity and Oesophageal Acid Exposure in Healthy Humans." Alimentary Pharmacology & Therapeutics, vol. 12, no. 11, 1998, pp. 1155-61.
Bruley des Varannes S, Duquesnoy C, Mamet JP, et al. Effects of tablet and effervescent formulations of ranitidine 75 mg and cimetidine 200 mg on gastric acidity and oesophageal acid exposure in healthy humans. Aliment Pharmacol Ther. 1998;12(11):1155-61.
Bruley des Varannes, S., Duquesnoy, C., Mamet, J. P., Slama, A., Galmiche, J. P., & Scarpignato, C. (1998). Effects of tablet and effervescent formulations of ranitidine 75 mg and cimetidine 200 mg on gastric acidity and oesophageal acid exposure in healthy humans. Alimentary Pharmacology & Therapeutics, 12(11), 1155-61.
Bruley des Varannes S, et al. Effects of Tablet and Effervescent Formulations of Ranitidine 75 Mg and Cimetidine 200 Mg On Gastric Acidity and Oesophageal Acid Exposure in Healthy Humans. Aliment Pharmacol Ther. 1998;12(11):1155-61. PubMed PMID: 9845405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of tablet and effervescent formulations of ranitidine 75 mg and cimetidine 200 mg on gastric acidity and oesophageal acid exposure in healthy humans. AU - Bruley des Varannes,S, AU - Duquesnoy,C, AU - Mamet,J P, AU - Slama,A, AU - Galmiche,J P, AU - Scarpignato,C, PY - 1998/12/9/pubmed PY - 1998/12/9/medline PY - 1998/12/9/entrez SP - 1155 EP - 61 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 12 IS - 11 N2 - BACKGROUND: Because of their tolerance and safety, low doses of H2-receptor antagonists are now increasingly used in some countries for self-care medication of gastro-oesophageal reflux symptoms. AIM: The purpose of this randomized, double-blind, placebo-controlled, five-way crossover study was to determine and to compare the effects of low doses of ranitidine and cimetidine both on gastric pH and on oesophageal acid exposure. METHODS: Gastric and oesophageal pH were simultaneously monitored in 20 healthy subjects using two glass pH electrodes, after placebo and single doses of ranitidine 75 mg and cimetidine 200 mg (effervescent and tablet forms), for 4 h before and after a meal. RESULTS: During the fasting period, median gastric pH rose significantly with both drugs, but more rapidly with the effervescent forms; the oesophageal acid exposure was significantly decreased by all drug regimens. After the meal, although there was no significant difference in gastric pH values, oesophageal acid exposure was significantly decreased in comparison with placebo with both forms of ranitidine (P < 0.05), and also for ranitidine tablets in comparison with cimetidine tablets (P < 0.05). CONCLUSIONS: Low doses of ranitidine and cimetidine increase gastric pH, with a more pronounced effect for ranitidine. Effervescent formulations of both drugs induce a slightly more rapid initial increase in pH than tablets. Ranitidine demonstrates a more prolonged effect than cimetidine and decreases oesophageal acid exposure monitored after a meal ingested 4 h after the drug intake. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/9845405/Effects_of_tablet_and_effervescent_formulations_of_ranitidine_75_mg_and_cimetidine_200_mg_on_gastric_acidity_and_oesophageal_acid_exposure_in_healthy_humans_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=1998&amp;volume=12&amp;issue=11&amp;spage=1155 DB - PRIME DP - Unbound Medicine ER -