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Structural correlates of cognitive deficits in a selected group of patients with Alzheimer's disease.

Abstract

OBJECTIVE

The objective of this study was to correlate the densities of neurofibrillary tangles (NFTs) and senile plaques (SPs) in 10 patients with Alzheimer's disease (AD) with comprehensive neuropsychological data obtained within 1 year of death.

BACKGROUND

Clinicopathologic studies in AD have been essentially limited to correlate neuropathologic data with severity of dementia. Very few studies have addressed the correlations between distribution of lesions and specific cognitive deficits. This is partly due to the limitation imposed by the interval between the last neuropsychological evaluation and death.

METHODS

Ten patients with a postmortem diagnosis of AD, with a mean age at death of 80.4+/-6.6 years and a mean duration of symptoms of 5.6+/-2.9 years, were selected for the study. All of these patients were submitted to neuropsychological testing within 1 year of death, including 17 tests assessing memory, language, visuoperceptual, visuospatial, and constructional abilities as well as limb praxis. The neuropathologic study was performed using a modified Bielschowsky technique. Mean densities of SPs and NFTs were determined in the hippocampal formation (CA1, subiculum, and parasubiculum) and in six neocortical areas (midfrontal, orbitofrontal, cingulum, fusiform gyrus, superior and inferior parietal cortices). Statistical correlations were determined between cognitive scores and SP and NFT densities.

RESULTS

For NFTs, significant correlations emerged only between tangle density in CA1 and visuoperceptual scores. For SP density values, significant correlations were found between visuoperceptual tests and lesions in the subiculum and in the fusiform gyrus, significant correlations were found between language scores and SPs in the superior parietal cortex and between visuospatial deficits and lesions in the superior parietal cortex and fusiform gyrus.

CONCLUSIONS

SPs in specific brain areas displayed a good correlation with the cognitive deficits detected in this selected group of AD patients. The association of fusiform gyrus and superior parietal lobule involvement with visuoperceptual and visuospatial deficits, respectively, is in agreement with current knowledge of the anatomic basis of visual processing.

Authors+Show Affiliations

Research Center, Geriatric Institute, University of Montréal, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9845409

Citation

Caramelli, P, et al. "Structural Correlates of Cognitive Deficits in a Selected Group of Patients With Alzheimer's Disease." Neuropsychiatry, Neuropsychology, and Behavioral Neurology, vol. 11, no. 4, 1998, pp. 184-90.
Caramelli P, Robitaille Y, Laroche-Cholette A, et al. Structural correlates of cognitive deficits in a selected group of patients with Alzheimer's disease. Neuropsychiatry Neuropsychol Behav Neurol. 1998;11(4):184-90.
Caramelli, P., Robitaille, Y., Laroche-Cholette, A., Nitrini, R., Gauvreau, D., Joanette, Y., & Lecours, A. R. (1998). Structural correlates of cognitive deficits in a selected group of patients with Alzheimer's disease. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 11(4), pp. 184-90.
Caramelli P, et al. Structural Correlates of Cognitive Deficits in a Selected Group of Patients With Alzheimer's Disease. Neuropsychiatry Neuropsychol Behav Neurol. 1998;11(4):184-90. PubMed PMID: 9845409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural correlates of cognitive deficits in a selected group of patients with Alzheimer's disease. AU - Caramelli,P, AU - Robitaille,Y, AU - Laroche-Cholette,A, AU - Nitrini,R, AU - Gauvreau,D, AU - Joanette,Y, AU - Lecours,A R, PY - 1998/12/9/pubmed PY - 1998/12/9/medline PY - 1998/12/9/entrez SP - 184 EP - 90 JF - Neuropsychiatry, neuropsychology, and behavioral neurology JO - Neuropsychiatry Neuropsychol Behav Neurol VL - 11 IS - 4 N2 - OBJECTIVE: The objective of this study was to correlate the densities of neurofibrillary tangles (NFTs) and senile plaques (SPs) in 10 patients with Alzheimer's disease (AD) with comprehensive neuropsychological data obtained within 1 year of death. BACKGROUND: Clinicopathologic studies in AD have been essentially limited to correlate neuropathologic data with severity of dementia. Very few studies have addressed the correlations between distribution of lesions and specific cognitive deficits. This is partly due to the limitation imposed by the interval between the last neuropsychological evaluation and death. METHODS: Ten patients with a postmortem diagnosis of AD, with a mean age at death of 80.4+/-6.6 years and a mean duration of symptoms of 5.6+/-2.9 years, were selected for the study. All of these patients were submitted to neuropsychological testing within 1 year of death, including 17 tests assessing memory, language, visuoperceptual, visuospatial, and constructional abilities as well as limb praxis. The neuropathologic study was performed using a modified Bielschowsky technique. Mean densities of SPs and NFTs were determined in the hippocampal formation (CA1, subiculum, and parasubiculum) and in six neocortical areas (midfrontal, orbitofrontal, cingulum, fusiform gyrus, superior and inferior parietal cortices). Statistical correlations were determined between cognitive scores and SP and NFT densities. RESULTS: For NFTs, significant correlations emerged only between tangle density in CA1 and visuoperceptual scores. For SP density values, significant correlations were found between visuoperceptual tests and lesions in the subiculum and in the fusiform gyrus, significant correlations were found between language scores and SPs in the superior parietal cortex and between visuospatial deficits and lesions in the superior parietal cortex and fusiform gyrus. CONCLUSIONS: SPs in specific brain areas displayed a good correlation with the cognitive deficits detected in this selected group of AD patients. The association of fusiform gyrus and superior parietal lobule involvement with visuoperceptual and visuospatial deficits, respectively, is in agreement with current knowledge of the anatomic basis of visual processing. SN - 0894-878X UR - https://www.unboundmedicine.com/medline/citation/9845409/Structural_correlates_of_cognitive_deficits_in_a_selected_group_of_patients_with_Alzheimer's_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9845409.ui DB - PRIME DP - Unbound Medicine ER -