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Plasma levels of selenium, selenoprotein P and glutathione peroxidase and their correlations to fish intake and serum levels of thyrotropin and thyroid hormones: a study on Latvian fish consumers.
Eur J Clin Nutr 1998; 52(11):796-800EJ

Abstract

OBJECTIVE

To study the relationships between fish intake and different markers of selenium status and thyroid hormone function.

DESIGN

Cross-sectional study.

SETTING AND SUBJECTS

Sixty-eight men (age 24-79 years) were recruited among coastal fishermen and inland subjects from Latvia. None of the subjects was on selenium medication or had any known endocrine disease.

MAIN OUTCOME MEASURES

Correlations between fish intake, plasma levels of selenium, selenoprotein P, glutathione peroxidase, organic mercury in erythrocytes and TSH in serum.

RESULTS

Selenium in plasma ranged from 0.30 to 1.56 micromol/l, selenoprotein P from 0.54 to 2.21 arbitrary units relative to pooled plasma, and glutathione peroxidase from 1.20 to 5.73 mg/l. The number of fish meals per month was correlated with plasma selenium, selenoprotein P and glutathione peroxidase (r = 0.63, r = 0.62 and r = 0.50, respectively; P<0.001). Plasma selenium was correlated with selenoprotein P and glutathione peroxidase (r = 0.88 and r = 0.67, respectively; P < 0.001), and also selenoprotein P and glutathione peroxidase were correlated (r = 0.63, P < 0.001). The mean plasma selenium level in those with a high fish intake (21-50 fish meals/month), was 81% higher than in those with lowest fish intake. TSH in serum was inversely correlated with plasma selenium and selenoprotein P. Thyroid hormone levels were not correlated with plasma selenium, selenoproteins or fish intake.

CONCLUSIONS

In this study group, selenium from fish intake had a marked impact on all variables studied on selenium status. No impact of selenium status on T3 and T4 levels was observed. The slightly negative correlation of selenium status with TSH levels might indicate a higher TSH secretion at low selenium status.

Authors+Show Affiliations

Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9846591

Citation

Hagmar, L, et al. "Plasma Levels of Selenium, Selenoprotein P and Glutathione Peroxidase and Their Correlations to Fish Intake and Serum Levels of Thyrotropin and Thyroid Hormones: a Study On Latvian Fish Consumers." European Journal of Clinical Nutrition, vol. 52, no. 11, 1998, pp. 796-800.
Hagmar L, Persson-Moschos M, Akesson B, et al. Plasma levels of selenium, selenoprotein P and glutathione peroxidase and their correlations to fish intake and serum levels of thyrotropin and thyroid hormones: a study on Latvian fish consumers. Eur J Clin Nutr. 1998;52(11):796-800.
Hagmar, L., Persson-Moschos, M., Akesson, B., & Schütz, A. (1998). Plasma levels of selenium, selenoprotein P and glutathione peroxidase and their correlations to fish intake and serum levels of thyrotropin and thyroid hormones: a study on Latvian fish consumers. European Journal of Clinical Nutrition, 52(11), pp. 796-800.
Hagmar L, et al. Plasma Levels of Selenium, Selenoprotein P and Glutathione Peroxidase and Their Correlations to Fish Intake and Serum Levels of Thyrotropin and Thyroid Hormones: a Study On Latvian Fish Consumers. Eur J Clin Nutr. 1998;52(11):796-800. PubMed PMID: 9846591.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma levels of selenium, selenoprotein P and glutathione peroxidase and their correlations to fish intake and serum levels of thyrotropin and thyroid hormones: a study on Latvian fish consumers. AU - Hagmar,L, AU - Persson-Moschos,M, AU - Akesson,B, AU - Schütz,A, PY - 1998/12/10/pubmed PY - 1998/12/10/medline PY - 1998/12/10/entrez SP - 796 EP - 800 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 52 IS - 11 N2 - OBJECTIVE: To study the relationships between fish intake and different markers of selenium status and thyroid hormone function. DESIGN: Cross-sectional study. SETTING AND SUBJECTS: Sixty-eight men (age 24-79 years) were recruited among coastal fishermen and inland subjects from Latvia. None of the subjects was on selenium medication or had any known endocrine disease. MAIN OUTCOME MEASURES: Correlations between fish intake, plasma levels of selenium, selenoprotein P, glutathione peroxidase, organic mercury in erythrocytes and TSH in serum. RESULTS: Selenium in plasma ranged from 0.30 to 1.56 micromol/l, selenoprotein P from 0.54 to 2.21 arbitrary units relative to pooled plasma, and glutathione peroxidase from 1.20 to 5.73 mg/l. The number of fish meals per month was correlated with plasma selenium, selenoprotein P and glutathione peroxidase (r = 0.63, r = 0.62 and r = 0.50, respectively; P<0.001). Plasma selenium was correlated with selenoprotein P and glutathione peroxidase (r = 0.88 and r = 0.67, respectively; P < 0.001), and also selenoprotein P and glutathione peroxidase were correlated (r = 0.63, P < 0.001). The mean plasma selenium level in those with a high fish intake (21-50 fish meals/month), was 81% higher than in those with lowest fish intake. TSH in serum was inversely correlated with plasma selenium and selenoprotein P. Thyroid hormone levels were not correlated with plasma selenium, selenoproteins or fish intake. CONCLUSIONS: In this study group, selenium from fish intake had a marked impact on all variables studied on selenium status. No impact of selenium status on T3 and T4 levels was observed. The slightly negative correlation of selenium status with TSH levels might indicate a higher TSH secretion at low selenium status. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/9846591/Plasma_levels_of_selenium_selenoprotein_P_and_glutathione_peroxidase_and_their_correlations_to_fish_intake_and_serum_levels_of_thyrotropin_and_thyroid_hormones:_a_study_on_Latvian_fish_consumers_ DB - PRIME DP - Unbound Medicine ER -