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Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion.
Eur J Clin Nutr. 1998 Nov; 52(11):805-12.EJ

Abstract

OBJECTIVE

To examine age-related differences in blood pressure, heart rate, behavioral mood state and norepinephrine kinetics after caffeine ingestion in younger and older men.

DESIGN

Placebo-controlled, double-blind study.

SETTING

General Clinical Research Center, University of Vermont.

SUBJECTS

10 older (O) (65-80 y) and 10 younger (Y) (19-26 y) healthy men who were moderate consumers of caffeine (Y= 126+/-30 mg/d; O = 160 44 mg/d:NS; mean +/- s.e.m.).

INTERVENTION

All volunteers were characterized for fasting plasma glucose, insulin and caffeine levels, body composition, anthropometry, physical activity, and energy intake. Before and after placebo and caffeine ingestion (5 mg/kg fat-free mass) test days, the following variables were measured in all subjects: heart rate, blood pressure, mood state, and norepinephrine concentrations (NEconc), appearance (NEapp) and clearance (NEcl).

MAIN OUTCOME MEASURES

Systolic and diastolic blood pressure, heart rate, mood state, and norepinephrine kinetic responses to placebo and caffeine ingestion.

RESULTS

Following caffeine ingestion, plasma caffeine levels were similar in Y and O men. Systolic (SBP) and diastolic (DBP) blood pressure increased significantly (P < 0.01) from baseline by 9% (130+/-6 vs 142+/-6 mmHg) and 3% (75+/-3 vs 77+/-3 mmHg), respectively, in O men following caffeine ingestion, but remained unchanged in Y men. Self-reported feelings of tension (P < 0.05) and anger (P = 0.06) decreased in O men, while anger tended to increase in Y men (P < 0.06) following caffeine ingestion. Heart rates in both groups were unaltered following caffeine ingestion. No differences were noted at baseline between O and Y men for NEconc, NEapp and NEcl. After caffeine ingestion, NEconc were significantly greater in O than Y men, whereas NEapp and NEcl rates did not differ from baseline in either group. Blood pressure and subjective mood state effects of caffeine were not related to changes in norepinephrine kinetics.

CONCLUSION

Age may play a role in augmenting blood pressure response and reducing subjective feelings of anger and tension following caffeine ingestion, suggesting that the elderly are more reactive to the pressor and less sensitive to the subjective effects of the drug. These effects do not appear to be mediated by changes in sympathetic nervous system activity.

Authors+Show Affiliations

Human Performance Laboratory, Skidmore College, Saratoga Springs, New York 12866-1632, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9846593

Citation

Arciero, P J., et al. "Relationship of Blood Pressure, Heart Rate and Behavioral Mood State to Norepinephrine Kinetics in Younger and Older Men Following Caffeine Ingestion." European Journal of Clinical Nutrition, vol. 52, no. 11, 1998, pp. 805-12.
Arciero PJ, Gardner AW, Benowitz NL, et al. Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion. Eur J Clin Nutr. 1998;52(11):805-12.
Arciero, P. J., Gardner, A. W., Benowitz, N. L., & Poehlman, E. T. (1998). Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion. European Journal of Clinical Nutrition, 52(11), 805-12.
Arciero PJ, et al. Relationship of Blood Pressure, Heart Rate and Behavioral Mood State to Norepinephrine Kinetics in Younger and Older Men Following Caffeine Ingestion. Eur J Clin Nutr. 1998;52(11):805-12. PubMed PMID: 9846593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion. AU - Arciero,P J, AU - Gardner,A W, AU - Benowitz,N L, AU - Poehlman,E T, PY - 1998/12/10/pubmed PY - 1998/12/10/medline PY - 1998/12/10/entrez SP - 805 EP - 12 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 52 IS - 11 N2 - OBJECTIVE: To examine age-related differences in blood pressure, heart rate, behavioral mood state and norepinephrine kinetics after caffeine ingestion in younger and older men. DESIGN: Placebo-controlled, double-blind study. SETTING: General Clinical Research Center, University of Vermont. SUBJECTS: 10 older (O) (65-80 y) and 10 younger (Y) (19-26 y) healthy men who were moderate consumers of caffeine (Y= 126+/-30 mg/d; O = 160 44 mg/d:NS; mean +/- s.e.m.). INTERVENTION: All volunteers were characterized for fasting plasma glucose, insulin and caffeine levels, body composition, anthropometry, physical activity, and energy intake. Before and after placebo and caffeine ingestion (5 mg/kg fat-free mass) test days, the following variables were measured in all subjects: heart rate, blood pressure, mood state, and norepinephrine concentrations (NEconc), appearance (NEapp) and clearance (NEcl). MAIN OUTCOME MEASURES: Systolic and diastolic blood pressure, heart rate, mood state, and norepinephrine kinetic responses to placebo and caffeine ingestion. RESULTS: Following caffeine ingestion, plasma caffeine levels were similar in Y and O men. Systolic (SBP) and diastolic (DBP) blood pressure increased significantly (P < 0.01) from baseline by 9% (130+/-6 vs 142+/-6 mmHg) and 3% (75+/-3 vs 77+/-3 mmHg), respectively, in O men following caffeine ingestion, but remained unchanged in Y men. Self-reported feelings of tension (P < 0.05) and anger (P = 0.06) decreased in O men, while anger tended to increase in Y men (P < 0.06) following caffeine ingestion. Heart rates in both groups were unaltered following caffeine ingestion. No differences were noted at baseline between O and Y men for NEconc, NEapp and NEcl. After caffeine ingestion, NEconc were significantly greater in O than Y men, whereas NEapp and NEcl rates did not differ from baseline in either group. Blood pressure and subjective mood state effects of caffeine were not related to changes in norepinephrine kinetics. CONCLUSION: Age may play a role in augmenting blood pressure response and reducing subjective feelings of anger and tension following caffeine ingestion, suggesting that the elderly are more reactive to the pressor and less sensitive to the subjective effects of the drug. These effects do not appear to be mediated by changes in sympathetic nervous system activity. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/9846593/Relationship_of_blood_pressure_heart_rate_and_behavioral_mood_state_to_norepinephrine_kinetics_in_younger_and_older_men_following_caffeine_ingestion_ L2 - https://doi.org/10.1038/sj.ejcn.1600651 DB - PRIME DP - Unbound Medicine ER -