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Factors affecting the success of human blastocyst development and pregnancy following in vitro fertilization and embryo transfer.
Fertil Steril. 1998 Dec; 70(6):1022-9.FS

Abstract

OBJECTIVE

To determine the factors affecting blastocyst development and pregnancy after IVF and ET.

DESIGN

Retrospective analysis of data arising from a clinical trial.

SETTING

Private in vitro fertilization clinic.

PATIENT(S)

Fifty-six patients aged < or = 40 years, undergoing IVF procedures for infertility, recruited specifically for blastocyst transfer.

INTERVENTION(S)

All zygotes were cultured to days 5 or 6 after insemination, and one to four of the most advanced blastocysts were transferred to the patient's uterus.

MAIN OUTCOME MEASURE(S)

Development of zygotes to blastocysts in vitro and pregnancy and implantation rates after ET.

RESULT(S)

Fifty-one percent of all zygotes developed to blastocysts. Significant positive correlation between the number of blastocysts formed was observed with the number of oocytes, pronuclear zygotes, and eight-cell embryos formed. There was a negative correlation with male factor infertility. By day 5 or 6, 93% of the patients had at least one blastocysts, and the clinical pregnancy rate per transfer was 43% and the implantation per embryo transferred was 25%. No other clinical factor significantly affected the number of blastocysts formed, pregnancy rate, or implantation rate.

CONCLUSION(S)

The numbers of oocytes, zygotes, and normally developing embryos in culture significantly affects the production of blastocysts in vitro. Male infertility significantly reduces blastocyst production. The number and the quality of the blastocysts transferred significantly influences clinical pregnancy rate.

Authors+Show Affiliations

Centre for Early Human Development, Monash University, Institute of Reproduction and Development, Clayton, Victoria, Australia. gayle.jones@med.monash.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9848289

Citation

Jones, G M., et al. "Factors Affecting the Success of Human Blastocyst Development and Pregnancy Following in Vitro Fertilization and Embryo Transfer." Fertility and Sterility, vol. 70, no. 6, 1998, pp. 1022-9.
Jones GM, Trounson AO, Lolatgis N, et al. Factors affecting the success of human blastocyst development and pregnancy following in vitro fertilization and embryo transfer. Fertil Steril. 1998;70(6):1022-9.
Jones, G. M., Trounson, A. O., Lolatgis, N., & Wood, C. (1998). Factors affecting the success of human blastocyst development and pregnancy following in vitro fertilization and embryo transfer. Fertility and Sterility, 70(6), 1022-9.
Jones GM, et al. Factors Affecting the Success of Human Blastocyst Development and Pregnancy Following in Vitro Fertilization and Embryo Transfer. Fertil Steril. 1998;70(6):1022-9. PubMed PMID: 9848289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors affecting the success of human blastocyst development and pregnancy following in vitro fertilization and embryo transfer. AU - Jones,G M, AU - Trounson,A O, AU - Lolatgis,N, AU - Wood,C, PY - 1998/12/16/pubmed PY - 1998/12/16/medline PY - 1998/12/16/entrez SP - 1022 EP - 9 JF - Fertility and sterility JO - Fertil. Steril. VL - 70 IS - 6 N2 - OBJECTIVE: To determine the factors affecting blastocyst development and pregnancy after IVF and ET. DESIGN: Retrospective analysis of data arising from a clinical trial. SETTING: Private in vitro fertilization clinic. PATIENT(S): Fifty-six patients aged < or = 40 years, undergoing IVF procedures for infertility, recruited specifically for blastocyst transfer. INTERVENTION(S): All zygotes were cultured to days 5 or 6 after insemination, and one to four of the most advanced blastocysts were transferred to the patient's uterus. MAIN OUTCOME MEASURE(S): Development of zygotes to blastocysts in vitro and pregnancy and implantation rates after ET. RESULT(S): Fifty-one percent of all zygotes developed to blastocysts. Significant positive correlation between the number of blastocysts formed was observed with the number of oocytes, pronuclear zygotes, and eight-cell embryos formed. There was a negative correlation with male factor infertility. By day 5 or 6, 93% of the patients had at least one blastocysts, and the clinical pregnancy rate per transfer was 43% and the implantation per embryo transferred was 25%. No other clinical factor significantly affected the number of blastocysts formed, pregnancy rate, or implantation rate. CONCLUSION(S): The numbers of oocytes, zygotes, and normally developing embryos in culture significantly affects the production of blastocysts in vitro. Male infertility significantly reduces blastocyst production. The number and the quality of the blastocysts transferred significantly influences clinical pregnancy rate. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/9848289/full_citation/Factors_affecting_the_success_of_human_blastocyst_development_and_pregnancy_following_in_vitro_fertilization_and_embryo_transfer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028298003422 DB - PRIME DP - Unbound Medicine ER -