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Effects of pretreatment with an oral contraceptive on the time required to achieve pituitary suppression with gonadotropin-releasing hormone analogues and on subsequent implantation and pregnancy rates.
Fertil Steril. 1998 Dec; 70(6):1063-9.FS

Abstract

OBJECTIVE

To assess the effect of pretreatment with an oral contraceptive (OC) on ovarian cyst formation during pituitary suppression with buserelin acetate.

DESIGN

Prospective randomized trial.

SETTING

Academic medical center.

PATIENT(S)

Eighty-three patients who were undergoing IVF-ET treatment.

INTERVENTION(S)

Patients in the study group were pretreated with an OC for 14 days starting on the first day of menstruation. The administration of SC buserelin acetate was initiated on the last day of OC administration. Patients in the control group began to receive buserelin acetate on day 2 of menstruation. Hormonal assays and ultrasound scans were performed on the first day of menstruation, and 7, 11, and 14 days after the commencement of buserelin acetate administration. Thereafter, these tests were performed weekly until pituitary suppression was achieved.

MAIN OUTCOME MEASURE(S)

Incidence of cyst formation.

RESULT(S)

A cyst developed in 27 patients in the control group (52.9%) and no patients in the study group (odds ratio [OR]=115; 95% confidence interval [CI]=10-617). Patients in the study group achieved pituitary suppression faster (median difference [MD]=7 days; 95% CI=4-14) and required fewer ampules of gonadotropin (MD=10; 95% CI=6-14). They recruited more follicles (MD=3; 95% CI=0-5) and had higher pregnancy rates (37.2% versus 33.3%).

CONCLUSION(S)

Pretreatment with an OC abolishes ovarian cyst formation, shortens the time required to achieve pituitary suppression, and decreases gonadotropin requirements without having a negative effect on pregnancy rates.

Authors+Show Affiliations

McGill Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9848296

Citation

Biljan, M M., et al. "Effects of Pretreatment With an Oral Contraceptive On the Time Required to Achieve Pituitary Suppression With Gonadotropin-releasing Hormone Analogues and On Subsequent Implantation and Pregnancy Rates." Fertility and Sterility, vol. 70, no. 6, 1998, pp. 1063-9.
Biljan MM, Mahutte NG, Dean N, et al. Effects of pretreatment with an oral contraceptive on the time required to achieve pituitary suppression with gonadotropin-releasing hormone analogues and on subsequent implantation and pregnancy rates. Fertil Steril. 1998;70(6):1063-9.
Biljan, M. M., Mahutte, N. G., Dean, N., Hemmings, R., Bissonnette, F., & Tan, S. L. (1998). Effects of pretreatment with an oral contraceptive on the time required to achieve pituitary suppression with gonadotropin-releasing hormone analogues and on subsequent implantation and pregnancy rates. Fertility and Sterility, 70(6), 1063-9.
Biljan MM, et al. Effects of Pretreatment With an Oral Contraceptive On the Time Required to Achieve Pituitary Suppression With Gonadotropin-releasing Hormone Analogues and On Subsequent Implantation and Pregnancy Rates. Fertil Steril. 1998;70(6):1063-9. PubMed PMID: 9848296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of pretreatment with an oral contraceptive on the time required to achieve pituitary suppression with gonadotropin-releasing hormone analogues and on subsequent implantation and pregnancy rates. AU - Biljan,M M, AU - Mahutte,N G, AU - Dean,N, AU - Hemmings,R, AU - Bissonnette,F, AU - Tan,S L, PY - 1998/12/16/pubmed PY - 1998/12/16/medline PY - 1998/12/16/entrez KW - Americas KW - Biology KW - Canada KW - Clinical Research KW - Comparative Studies KW - Contraception KW - Contraceptive Methods--therapeutic use KW - Developed Countries KW - Diseases KW - Endocrine System KW - Family Planning KW - Fertilization KW - Genitalia KW - Genitalia, Female KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - In Vitro KW - Infertility KW - North America KW - Northern America KW - Oral Contraceptives, Combined--therapeutic use KW - Oral Contraceptives--therapeutic use KW - Ovarian Cysts KW - Ovarian Effects KW - Ovary KW - Physiology KW - Reproduction KW - Research Methodology KW - Research Report KW - Studies KW - Treatment KW - Urogenital System SP - 1063 EP - 9 JF - Fertility and sterility JO - Fertil Steril VL - 70 IS - 6 N2 - OBJECTIVE: To assess the effect of pretreatment with an oral contraceptive (OC) on ovarian cyst formation during pituitary suppression with buserelin acetate. DESIGN: Prospective randomized trial. SETTING: Academic medical center. PATIENT(S): Eighty-three patients who were undergoing IVF-ET treatment. INTERVENTION(S): Patients in the study group were pretreated with an OC for 14 days starting on the first day of menstruation. The administration of SC buserelin acetate was initiated on the last day of OC administration. Patients in the control group began to receive buserelin acetate on day 2 of menstruation. Hormonal assays and ultrasound scans were performed on the first day of menstruation, and 7, 11, and 14 days after the commencement of buserelin acetate administration. Thereafter, these tests were performed weekly until pituitary suppression was achieved. MAIN OUTCOME MEASURE(S): Incidence of cyst formation. RESULT(S): A cyst developed in 27 patients in the control group (52.9%) and no patients in the study group (odds ratio [OR]=115; 95% confidence interval [CI]=10-617). Patients in the study group achieved pituitary suppression faster (median difference [MD]=7 days; 95% CI=4-14) and required fewer ampules of gonadotropin (MD=10; 95% CI=6-14). They recruited more follicles (MD=3; 95% CI=0-5) and had higher pregnancy rates (37.2% versus 33.3%). CONCLUSION(S): Pretreatment with an OC abolishes ovarian cyst formation, shortens the time required to achieve pituitary suppression, and decreases gonadotropin requirements without having a negative effect on pregnancy rates. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/9848296/Effects_of_pretreatment_with_an_oral_contraceptive_on_the_time_required_to_achieve_pituitary_suppression_with_gonadotropin_releasing_hormone_analogues_and_on_subsequent_implantation_and_pregnancy_rates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028298003331 DB - PRIME DP - Unbound Medicine ER -